Sensitivity of different areas of the flexor aspect of the human forearm to corticosteroid-induced skin blanching

Title: Sensitivity of different areas of the flexor aspect of the human forearm to corticosteroid-induced skin blanching
Creator: Meyer, Eric
Creator: Smith, Eric W
Creator: Haigh, John M
Date Issued: 1992
Date: 1992
Type: Article
Identifier: vital:6394
Identifier: http://hdl.handle.net/10962/d1006317
Description: The intensity of corticosteroid-induced blanching has been found to vary at different areas of the flexor aspect of the human forearm. A retrospective analysis of 38,880 observations of skin blanching in 56 volunteers was conducted to assess the sensitivity of forearm skin to betamethasone 17-valerate. The mid-forearm appears to be more sensitive to the blanching response than do the areas close to the wrist or elbow. These results indicate that each preparation under evaluation should be applied to several sites along the forearm when using the human skin blanching assay in order to obtain an accurate comparative assessment of corticosteroid release from topical delivery vehicles.
Format: 3 pages
Format: pdf
Language: English
Relation: Meyer, E. and Smith, E.W. and Haigh, J.M. (1992) Sensitivity of different areas of the flexor aspect of the human forearm to corticosteroid-induced skin blanching. British Journal of Dermatology, 127 (4). pp. 379-381. Available: http://dx.doi.org/10.1111/j.1365-2133.1992.tb00457...

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RU Department of Pharmacy

Haigh, JM (Prof)

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