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Kaye, Perry T

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Date: 2019
Language: English
Type: text
Identifier: http://hdl.handle.net/10962/67646
Description: The identity of the enzyme(s) responsible for the biosynthetic transformation of cinnamic acid derivatives to important, naturally occurring coumarins has yet to be established. This study constitutes ... More
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Date: 2018
Language: English
Type: text
Identifier: http://hdl.handle.net/10962/62235
Description: Expected release date-April 2019
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Authors: Singh, Alicia
Date: 2017
Language: English
Type: Thesis
Identifier: http://hdl.handle.net/10962/50558
Description: Fenchone and camphor are essential natural products that are available optically pure and contribute to the chiral pool in asymmetric synthesis. Further, they are both derivatives of norbornane, a str ... More
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Date: 2017
Language: English
Type: Thesis
Identifier: http://hdl.handle.net/10962/4888
Description: Globally, the eradication of malaria has been challenging due to the problem of resistance that past and currently available drugs exhibit. This is exacerbated by the inherent need for anti-malarial d ... More
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Date: 2017
Language: English
Type: text
Identifier: http://hdl.handle.net/10962/61790
Description: Expected release date-May 2019
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Date: 2016
Language: English
Type: text
Identifier: http://hdl.handle.net/10962/62955
Description: Thesis embargoed for one-year period. Expected date of release: April 2019
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Authors: Hassan, Yusuf
Date: 2016
Language: English
Type: Thesis
Identifier: http://hdl.handle.net/10962/550
Description: Four new (+)-ketopinic acid-derived Mn(III) complexes, three of which possess pseudo C2- symmetry, were synthesised as chiral catalyst candidates. The ligands were prepared by refluxing (+)-ketopinic ... More
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Date: 2015
Language: English
Type: Thesis
Identifier: vital:4540
Description: The application of Baylis-Hillman methodology has afforded access to a range of β-hydroxypropionate ester-AZT conjugates as potential dual-action HIV-1 IN/RT inhibitors. Two families comprising a tota ... More
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Date: 2015
Language: English
Type: Thesis
Identifier: vital:4546
Description: This project has been concerned with the application of the Baylis-Hillman methodology to the synthesis of medicinally important diketo acid analogues (cinnamate ester-AZT conjugates and 3-hydroxy est ... More
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Date: 2015
Language: English
Type: text
Identifier: http://hdl.handle.net/10962/54645
Description: Considerable efforts have been made in the modification of existing antimalarial drugs, and the support of incentive programmes have led to a drastic decrease in malaria cases reported by WHO during t ... More
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Date: 2013-07-19
Language: English
Type: Thesis
Identifier: vital:4451
Description: Malaria continues to be an enormous health-threat in the developing world and the emergence of drug resistance has further compounded the problem. The parasite-specific enzyme, 1-deoxY-D-xylulose-S-ph ... More
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Date: 2013-05-28
Language: English
Type: Thesis
Identifier: vital:4450
Description: A series of polydentate POM-selective, sulfur-containing amide ligands have been synthesized from ro-dibromoalkanes and mercaptoacetanilide, The resulting 3,6- dithiaoctanediamides and 3,7-dithianonan ... More
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Date: 2013
Language: English
Type: Thesis
Identifier: vital:4439
Description: The overall approach in the present investigation has been to explore applications of the Morita-Baylis-Hillman (MBH) reaction in asymmetric synthesis and in the continuation of systems with medicinal ... More
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Date: 2012
Language: English
Type: Thesis
Identifier: vital:4410
Description: This project has focused on exploring the application of Baylis-Hillman (BH) {a.k.a. Morita-Baylis-Hillman (MBH)} scaffolds in the construction of various compounds with medicinal potential. A series ... More
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Authors: Nyoni, Dubekile
Date: 2012
Language: English
Type: Thesis
Identifier: vital:4400
Description: This study has focussed on the application of synthetic, kinetic and exploratory theoretical methods in elucidating the reaction mechanisms of four Morita-Baylis-Hillman (MBH) type reactions, viz, i) ... More
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