https://vital.seals.ac.za/vital/access/manager/Index ${session.getAttribute("locale")} 5 https://vital.seals.ac.za/vital/access/manager/Repository/vital:4604 Wed 12 May 2021 23:36:54 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:3830 randomly methylated-β-CD (RM-β-CD) > β-CD ≈ 2-hydroxypropyl-β-CD (2HP-β- CD) > γ-CD ≥ 2-hydroxypropyl-γ-CD (2HP-γ-CD). An industrially applicable kneading method yielded binary systems with spectral and thermal characteristics similar to the respective physical mixtures, implying weak solid-state inclusion complexation. Preparation of an amorphous nifedipine - RM-β-CD product using a heating method is reported. A 1.7- and 1.9-fold improvement in solid-state nifedipine photostability was observed for I : 1 molar ratio β-CD and γ-CD kneaded products, respectively, when exposed to window-filtered daylight and could be attributed to changes in opacity of the crystalline kneaded products. The remaining cyclodextrins produced negligible nifedipine photostabilization. Nifedipine in vitro dissolution was improved considerably from γ-CD and RM-β-CD .kneaded products as a result of increased nifedipine wettability, solubility and reduced particle size. iii]]> Wed 12 May 2021 23:14:34 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:3191 Wed 12 May 2021 22:29:23 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:4409 Wed 12 May 2021 19:42:31 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:4007 Wed 12 May 2021 19:29:13 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:4001 Wed 12 May 2021 18:20:35 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:4417 99% d.e. for the bomane-2,3-diol acetals. In order to increase diastereofacial selectivity, a camphor-derived diol having a bulky substituent at C-10 was prepared, viz., phenyl 2,3-dihydroxybomane-10sulfonate, and α,β-unsaturated acetals of this diol were shown to undergo Simmons-Smith cyclopropanation with complete topological control (>99% d.e.), the diastereoselectivities being conveniently determined by ¹H and ¹³C NMR spectroscopy. Computer modelling, with the software package HYPERCHEM®, was used to explore the stereochemical aspects of the Simmons-Smith cyclopropanation, and hydrolysis of one of the cyclopropyl acetals has permitted the diastereoselective bias to be confirmed. (+)-Pinane-2,3-diol was also investigated as a chiral auxiliary in the Simmons-Smith reactions of α,β-unsaturated aldehydes, and moderate diastereoselectivities (20-30% d.e.) were observed. In a series of exploratory studies, the Diels-Alder reaction of the 2,3-dihydroxybomane-10-sulfonate acetal of trans-cinnamaldehyde with cyclopentadiene afforded a single cycloadduct, while OSO₄ dihydroxylation, MCPBA oxidation and alkylation of chiral acetals produced from both bomane-2,3-diol and phenyl 2,3-dihydroxybomane-10-sulfonate were less selective.]]> Wed 12 May 2021 18:04:19 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:4429 Wed 12 May 2021 16:36:44 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:4198 Thu 13 May 2021 08:12:44 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:2534 Thu 13 May 2021 06:58:23 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:3715 Thu 13 May 2021 06:32:59 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:3341 Thu 13 May 2021 06:13:51 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:5242 Thu 13 May 2021 05:30:31 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:3042 Thu 13 May 2021 04:51:55 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:5705 Thu 13 May 2021 04:30:08 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:3080 Thu 13 May 2021 03:47:50 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:5143 Thu 13 May 2021 02:25:57 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:4006 Thu 13 May 2021 01:04:21 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:5628 Thu 13 May 2021 00:32:18 SAST ]]>