- Title
- Development of an antiretroviral solid dosage form using multivariate analysis
- Creator
- Nqabeni, Luxolo
- Subject
- Analysis of variance
- Subject
- Experimental design
- Subject
- Multivariate analysis
- Subject
- Antiretroviral agents -- South Africa
- Date Issued
- 2007
- Date
- 2007
- Type
- Thesis
- Type
- Masters
- Type
- MSc
- Identifier
- vital:10145
- Identifier
- http://hdl.handle.net/10948/705
- Identifier
- Analysis of variance
- Identifier
- Experimental design
- Identifier
- Multivariate analysis
- Identifier
- Antiretroviral agents -- South Africa
- Description
- The aim of pharmaceutical development is to design a quality product and the manufacturing process to deliver the product in a reproducible manner. The development of a new and generic formulation is based on a large number of experiments. Statistics provides many tools for studying the conditions of formulations and processes and enables us to optimize the same while being able to minimize our experimentation. The purpose of this study was to apply experimental design methodology (DOE) and multivariate analysis to the development and optimization of tablet formulations containing 150 mg lamivudine manufactured by direct compression.
- Format
- xiii, 163 leaves
- Format
- Publisher
- Nelson Mandela Metropolitan University
- Publisher
- Faculty of Health Sciences
- Language
- English
- Rights
- Nelson Mandela Metropolitan University
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