Latrunculid sponges, their microbial communities and secondary metabolites: connecting conserved bacterial symbionts to pyrroloiminoquinone production

Dorrington, Rosemary A; Hilliar, Storm Hannah; Kalinski, Jarmo-Charles J; Krause, Rui W M; McPhail, Kerry L; Parker-Nance, Shirley; Wlalmsley, Tara A; Waterworth, Samantha C

Title: Latrunculid sponges, their microbial communities and secondary metabolites: connecting conserved bacterial symbionts to pyrroloiminoquinone production
Creator: Dorrington, Rosemary A
Creator: Hilliar, Storm Hannah
Creator: Kalinski, Jarmo-Charles J
Creator: Krause, Rui W M
Creator: McPhail, Kerry L
Creator: Parker-Nance, Shirley
Creator: Wlalmsley, Tara A
Creator: Waterworth, Samantha C
Date Issued: 2016
Date: 2016
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/65915
Identifier: vital:28858
Identifier: https://doi.org/10.1055/s-0036-1596655
Description: publisher version
Description: The Latrunculiidae are cold water sponges known for their production of bioactive pyrroloiminoquinone alkaloids (e.g. makaluvamines, discorhabdins and tsitsikammamines). Since pyrroloiminoquinones have also been isolated from sponges belonging to other families, ascidians and microorganisms, the biosynthetic origin of these alkaloids in latrunculid sponges is likely microbial. This study focuses on the secondary metabolites produced by closely-related Tsitsikamma species and Cyclacanthia bellae, all latrunculid sponges endemic to Algoa Bay on the South African southeast coast. The sponges produced suites of related pyrroloiminoquinones, including tsitsikammine A and B, and discohabdin C and V, the combination and relative abundance of which is species-specific. Characterisation of the diversity of sponge-associated bacterial communities revealed the unprecedented conservation of two dominant bacterial species. The first, a Betaproteobacterium, is also found in other latrunculids and related sponge families, representing a novel clade of sponge endosymbionts that have co-evolved with their hosts. The second conserved bacterial symbiont is a spirochaete found only in Cyclacanthia and Tsitsikamma species that is likely to have been recruited from free-living spirochaetes in the environment. This study sheds new light on the interactions between latrunculid sponges, their dominant bacterial symbionts, and the potential involvement of these bacteria in pyrroloiminoquinone biosynthesis.
Format: pdf
Publisher: Georg Thieme Verlag KG
Language: English
Relation: Planta Medica
Relation: Dorrington, Rosemary A., Hilliar, S.H., Kalinsky, J.C.J., Krause, R.W.M., McPhail, K.L., Parker-Nance, S., Wlamsley, T.A., Waterworth, S.C. (2016) Latrunculid sponges, their microbial communities and secondary metabolites: connecting conserved bacterial symbionts to pyrroloiminoquinone production. Planta Medica, 82 (S 01): p.596.https://doi.org/10.1055/s-0036-1596655
Relation: Planta Medica volume 82 number S01 S596 S596 2016 0032-0943
Rights: Thieme Planta Medica
Rights: Use of this resource is governed by the terms and conditions of the National Library of South Africa Copyright Act (http://www.nlsa.ac.za/downloads/Copyright Act.pdf)

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Dorrington, Rosemary A (Prof)

RU DST/NRF SARChI for Marine Natural Products

Krause, Rui Werner Maçedo (Prof)

RU Department of Chemistry

SDG 14. Life Below Water

SDG 03. Good Health and Well-Being

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