Interacting motif networks located in hotspots associated with RNA release are conserved in Enterovirus capsids

Ross, Caroline J; Knox, Caroline M; Tastan Bishop, Özlem

Title: Interacting motif networks located in hotspots associated with RNA release are conserved in Enterovirus capsids
Creator: Ross, Caroline J
Creator: Knox, Caroline M
Creator: Tastan Bishop, Özlem
Date Issued: 2017
Date: 2017
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/124855
Identifier: vital:35704
Identifier: https://doi.10.1002/1873-3468.12663
Description: Enteroviruses are responsible for a multitude of human diseases. Expansion of the virus capsid is associated with a cascade of conformational changes that allow the subsequent release of RNA. For the first time, this study presents a comprehensive bioinformatic screen for the prediction of interacting motifs within intraprotomer interfaces and across respective interfaces surrounding the fivefold and twofold axes. The results identify a network of conserved motif residues involved in interactions in enteroviruses that may be critical to capsid stabilisation, providing guidelines towards developing antivirals that interfere with viral expansion during RNA release.
Format: 15 pages
Format: pdf
Language: English
Relation: FEBS Letters
Relation: Ross, C., Knox, C. and Bishop, Ö.T., 2017. Interacting motif networks located in hotspots associated with RNA release are conserved in Enterovirus capsids. FEBS letters, 591(12), pp.1687-1701
Relation: FEBS Letters volume 591 number 12 1687 1701 2017 0014-5793
Rights: FEBS Letters
Rights: Use of this resource is governed by the terms and conditions of the Wiley Online Library Terms of Use statement (https://onlinelibrary.wiley.com/terms-and-conditions)

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Knox, Caroline M (Prof)

Tastan Bishop, Ozlem (Prof)

RU Research Unit in Bioinformatics (RUBi)

RU Department of Biochemistry, Microbiology and Bioinformatics

SDG 03. Good Health and Well-Being

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