Synthesis and anti-parasitic activity of C-benzylated (N-arylcarbamoyl) alkylphosphonate esters

Adeyemi, Christiana Modupe; Isaacs, Michelle; Mnkandhla, Dumisani; Krause, Rui W M; Klein, Rosalyn; Hoppe, Heinrich C; Lobb, Kevin A; Kaye, Perry T

Title: Synthesis and anti-parasitic activity of C-benzylated (N-arylcarbamoyl) alkylphosphonate esters
Creator: Adeyemi, Christiana Modupe
Creator: Isaacs, Michelle
Creator: Mnkandhla, Dumisani
Creator: Krause, Rui W M
Creator: Klein, Rosalyn
Creator: Hoppe, Heinrich C
Creator: Lobb, Kevin A
Creator: Kaye, Perry T
Date Issued: 2017
Date: 2017
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/125641
Identifier: vital:35803
Identifier: https://doi.org/10.1016/j.tet.2017.01.045
Description: Unexpected substituent-dependent regioselectivty challenges in the synthesis of C-benzylated (N-arylcarbamoyl)phosphonate esters have been resolved. The C-benzylated N-furfurylcarbamoyl derivative showed low micromolar PfLDH inhibition, while one of the C-benzylated N-arylcarbamoyl analogues was active against Nagana Trypanosoma brucei parasites which are responsible for African trypanosomiasis in cattle.
Format: 7 pages
Format: pdf
Language: English
Relation: Tetrahedron
Relation: Adeyemi, C.M., Isaacs, M., Mnkandhla, D., Klein, R., Hoppe, H.C., Krause, R.W., Lobb, K.A. and Kaye, P.T., 2017. Synthesis and anti-parasitic activity of C-benzylated (N-arylcarbamoyl) alkylphosphonate esters. Tetrahedron, 73(13), pp.1661-1667.
Relation: Tetrahedron number 73 number 13 1661 1667 2017 0040-4020
Rights: Tetrahedron
Rights: Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)

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Krause, Rui Werner Maçedo (Prof)

Klein, Rosalyn (Assoc Prof)

RU Centre for Chemico- and Biomedicinal Research (CCBR)

Lobb, Kevin Allan (Assoc Prof)

Hoppe, Heinrich C (Prof)

Isaacs, Michelle (Mrs)

Kaye, Perry T (Distinguished Fellow Emeritus Professor)

RU Department of Chemistry

SDG 03. Good Health and Well-Being

RU Department of Biochemistry, Microbiology and Bioinformatics

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