Synthesis and reactions of sugar chlorosulphates

Title: Synthesis and reactions of sugar chlorosulphates
Creator: Glass, Beverley Dawn
Subject: Chemical reactions Sugar -- Synthesis
Date Issued: 1982
Date: 1982
Type: Thesis
Type: Doctoral
Type: PhD
Identifier: vital:3826
Identifier: http://hdl.handle.net/10962/d1006145
Description: Summary: Partially chlorosulphated derivatives were synthesised for the purpose of examining the reactions of the chlorosulphonyloxy group in the presence of free hydroxyl groups. The behaviour of the chlorosulphonyloxy group was investigated under acidic conditions. Since sterically favoured chlorosulphonyloxy groups undergo facile replacement by chlorine to form chlorodeoxy sugars, some compounds possessing chlorosulphonyloxy groups which,due to polar and steric effects are not replaced by chloride,were investigated with a view to possible activation of the unfavourable centres towards nucleophilic substitution, thereby making available previously inaccessible chlorodeoxy sugars.
Format: 157 leaves
Format: pdf
Publisher: Rhodes University
Publisher: Faculty of Pharmacy, Pharmacy
Language: English
Rights: Glass, Beverley Dawn

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