Structure-based analysis of single nucleotide variants in the renin-angiotensinogen complex:

Brown, David K; Olivier, Sheik Amamuddy; Tastan Bishop, Özlem

Title: Structure-based analysis of single nucleotide variants in the renin-angiotensinogen complex:
Creator: Brown, David K
Creator: Olivier, Sheik Amamuddy
Creator: Tastan Bishop, Özlem
Date Issued: 2017
Date: 2017
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/147994
Identifier: vital:38700
Identifier: https://doi.org/10.1016/j.gheart.2017.01.006
Description: The renin-angiotensin system (RAS) plays an important role in regulating blood pressure and controlling sodium levels in the blood. Hyperactivity of this system has been linked to numerous conditions including hypertension, kidney disease, and congestive heart failure. Three classes of drugs have been developed to inhibit RAS. In this study, we provide a structure-based analysis of the effect of single nucleotide variants (SNVs) on the interaction between renin and angiotensinogen with the aim of revealing important residues and potentially damaging variants for further inhibitor design purposes.
Format: 12 pages
Format: pdf
Language: English
Relation: Global heart
Relation: Brown, D.K., Amamuddy, O.S. and Bishop, Ö.T., 2017. Structure-based analysis of single nucleotide variants in the renin-angiotensinogen complex. Global heart, 12(2), pp.121-132.
Relation: Global heart volume 12 number 2 121 132 June 2017 2211-8179
Rights: Publisher
Rights: Use of this resource is governed by the terms and conditions of the Elsevier Terms and conditions statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)

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Tastan Bishop, Ozlem (Prof)

RU Research Unit in Bioinformatics (RUBi)

RU Department of Biochemistry, Microbiology and Bioinformatics

SDG 03. Good Health and Well-Being

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