- Title
- The effects of vascular targeted bi-functionalized aunps on hepatic lipid metabolism of a diet-induced rats
- Creator
- Singo, Dakalo Gladwell
- Subject
- Bile acids
- Date Issued
- 2020
- Date
- 2020
- Type
- Thesis
- Type
- Masters
- Type
- MSc
- Identifier
- http://hdl.handle.net/10948/47072
- Identifier
- vital:39780
- Description
- Introduction: Obesity is a metabolic disease in which the accumulation of excessive fat in the adipose tissue may interfere with the normal maintenance of a healthy state. However, there is only a limited number of drugs approved for the treatment of obesity. For this purpose, target therapies are receiving more attention as a preferred treatment to reduce the burden of chronic diseases which are associated with the current strategies. Nanotechnology is a highly promising field that offers a nanotechnology-based drug delivery system as a novel means of solving issues associated with the toxicity of conventional anti-obesity drugs. Vascular targeted nanotherapy (targeted bi-functionalized nanoparticles) as a strategy that can overcome the current available anti-obesity drugs. Aim: This study sought to understand the effects of nanotherapy in the hepatic lipid metabolism and secretion of bile acids Research focus: The effects of gold nanotherapy on the bile acid biosynthetic enzymes, transporters and lipogenic enzymes of rats that were on a high fat diet. Conclusion: The study shows low expression in the majority of genes responsible for bile acid synthesis and a lipogenic pathway; therefore, the effects of nanotherapy exhibit low toxicity in the hepatic lipid metabolism.
- Format
- xiii, 75 leaves
- Format
- Publisher
- Nelson Mandela University
- Publisher
- Faculty of Science
- Language
- English
- Rights
- Nelson Mandela University
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NMU School of Medicinal Sciences
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Singo, DG 217177921Dissertation April 2020.pdf | 1 MB | Adobe Acrobat PDF | View Details Download |