- Title
- In vitro Anti-trypanosomal activities of indanone-based chalcones:
- Creator
- Beteck, Richard M
- Creator
- Legoabe, Lesetje J
- Creator
- Isaacs, Michelle
- Creator
- Hoppe, Heinrich C
- Date Issued
- 2019
- Date
- 2019
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/158280
- Identifier
- vital:40169
- Identifier
- https://doi.org/10.3354/meps12953
- Description
- Human African trypanosomiasis is a neglected infectious disease that affects mostly people living in the rural areas of Africa. Current treatment options are limited to just four drugs that have been in use of four to nine decades. The life-threatening toxic side-effects associated with the use of these drugs are disconcerting. Poor efficacy, low oral bioavailability, and high cost are other shortcomings of current HAT treatments. Evaluating the potentials of known hits for other therapeutic areas may be a fast and convenient method to discover new hit compounds against alternative targets. A library of 34 known indanone based chalcones was screened against T.b. brucei and nine potent hits, having IC50 values between 0.5–8.9 µM, were found. The SAR studies of this series could provide useful information in guiding future exploration of this class of compounds in search of more potent, safe, and low cost anti-trypanosomal agents.
- Format
- 14 pages
- Format
- Language
- English
- Relation
- Marine Ecology Progress Series
- Relation
- Maggs, J.Q., Cowley, P.D., Porter, S.N. and Childs, A.R., 2019. Should I stay or should I go? Intra-population variability in movement behaviour of wide-ranging and resident coastal fishes. Marine Ecology Progress Series, 619, pp.111-124
- Relation
- Marine Ecology Progress Series volume 619 number 111 124 2019 1616-1599
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Thieme Privacy Statement (https://www.thieme.de/de/thieme-gruppe/privacy-policy-statement-Thieme-EN.htm)
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RU Centre for Chemico- and Biomedicinal Research (CCBR)
Hoppe, Heinrich C (Prof)
Isaacs, Michelle (Mrs)
RU Department of Biochemistry, Microbiology and Bioinformatics
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | In vitro Anti-trypanosomal activities of indanone-based chalcones.pdf | 315 KB | Adobe Acrobat PDF | View Details Download |