- Title
- The palladacycle, AJ-5, exhibits anti-tumour and anti-cancer stem cell activity in breast cancer cells:
- Creator
- Aliwaini, Saeb
- Creator
- Peres, Jade
- Creator
- Kröger, Wendy L
- Creator
- Blanckenberg, Angelique
- Creator
- de la Mare, Jo-Anne
- Creator
- Edkins, Adrienne L
- Creator
- Mapolie, Selwyn
- Creator
- Prince, Sharon
- Date Issued
- 2015
- Date
- 2015
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/164874
- Identifier
- vital:41180
- Identifier
- DOI: 10.1016/j.canlet.2014.11.027
- Description
- Breast cancer is the most common malignancy amongst women worldwide but despite enormous efforts to address this problem, there is still limited success with most of the current therapeutic strategies. The current study describes the anti-cancer activity of a binuclear palladacycle complex (AJ-5) in oestrogen receptor positive (MCF7) and oestrogen receptor negative (MDA-MB-231) breast cancer cells as well as human breast cancer stem cells. AJ-5 is shown to induce DNA double strand breaks leading to intrinsic and extrinsic apoptosis and autophagy cell death pathways which are mediated by the p38 MAP kinase. This study provides evidence that AJ-5 is potentially an effective compound in the treatment of breast cancer.
- Format
- 13 pages
- Format
- Language
- English
- Relation
- Cancer letters
- Relation
- Aliwaini, S., Peres, J., Kröger, W.L., Blanckenberg, A., de la Mare, J., Edkins, A.L., Mapolie, S. and Prince, S., 2015. The palladacycle, AJ-5, exhibits anti-tumour and anti-cancer stem cell activity in breast cancer cells. Cancer letters, 357(1), pp.206-218
- Relation
- Cancer letters volume 357 number 1 206 218 2015 1872-7980
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
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RU DST/NRF SARChI for Molecular and Cellular Biology of the Eukaryotic Stress Response
De la Mare, Jo-Anne (Dr)
Edkins, Adrienne Lesley (Associate Prof)
RU Department of Biochemistry, Microbiology and Bioinformatics
SDG 03. Good Health and Well-Being
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