- Title
- Heterodimer formation by Oct4 and Smad3 differentially regulates epithelial-to-mesenchymal transition-associated factors in breast cancer progression:
- Creator
- Mandal, Gunjan
- Creator
- Biswas, Subir
- Creator
- Chowdhury, Sougata R
- Creator
- Chatterjee, Annesha
- Creator
- Purohit, Suman
- Creator
- Khamaru, Poulomi
- Creator
- Chakraborty, Sayan
- Creator
- Mandal, Palash K
- Creator
- Gupta, Arnab
- Creator
- de la Mare, Jo-Anne
- Creator
- Edkins, Adrienne L
- Creator
- Bhattacharyya, Arindam
- Date Issued
- 2018
- Date
- 2018
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/164907
- Identifier
- vital:41183
- Identifier
- DOI: 10.1016/j.bbadis.2018.03.010
- Description
- The multifunctional cytokine TGF-β crucially participates in breast cancer (BCa) metastasis and works differently in the disease stages, thus contributing in BCa progression. We address connections between TGF-β and the stem cell-related transcription factor (TF) Oct4 in BCa. In 147 BCa patients with infiltrating duct carcinoma, we identified a significantly higher number of cases with both moderate/high Oct4 expression and high TGF-β in late stages compared to early stages of the disease.
- Format
- 14 pages
- Format
- Language
- English
- Relation
- Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease
- Relation
- Mandal, G., Biswas, S., Chowdhury, S.R., Chatterjee, A., Purohit, S., Khamaru, P., Chakraborty, S., Mandal, P.K., Gupta, A., de la Mare, J.A. and Edkins, A.L., 2018. Heterodimer formation by Oct4 and Smad3 differentially regulates epithelial-to-mesenchymal transition-associated factors in breast cancer progression. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1864(6), pp.2053-2066
- Relation
- Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease volume 1864 number 6 2053 2066 2018 0925-4439
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
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RU DST/NRF SARChI for Molecular and Cellular Biology of the Eukaryotic Stress Response
De la Mare, Jo-Anne (Dr)
Edkins, Adrienne Lesley (Associate Prof)
RU Department of Biochemistry, Microbiology and Bioinformatics
SDG 03. Good Health and Well-Being
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