- Title
- Preformulation characterization and identification of excipients for nevirapine loaded niosomes
- Creator
- Witika, Bwalya A
- Creator
- Walker, Roderick B
- Subject
- To be catalogued
- Date Issued
- 2021
- Date
- 2021
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/183126
- Identifier
- vital:43914
- Identifier
- xlink:href="https://doi.org/10.1691/ph.2021.0137"
- Description
- Nevirapine (NVP) is used for the management of HIV/AIDS but must be dosed frequently, exhibits unpredictable bioavailability and a side effect profile that includes hepato- and dermo-toxicity. Niosomes are a colloidal drug delivery system that may be used to overcome the low bioavailability, side effect profile and frequent dosing needed when using conventional drug delivery systems. The compatibility of NVP with sorbitan esters, polysorbate, cholesterol and dihexadecyl phosphate (DCP) was investigated using Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy (SEM), Fourier Transform Infra-red Spectroscopy (FTIR) and X-ray Powder Diffraction (XRPD). Screening studies were undertaken to identify potential excipients that would produce niosomes with target critical quality attributes (CQA) viz, a particle size (PS) less than 1000 nm, a polydispersity index (PDI) less than 0.500 and an entrapment efficiency greater than 90%. The results revealed that sorbitan esters in combination with cholesterol and 5 μmol DCP produced niosomes with the best CQA and Zeta potential (ZP) less than -30 mV which suggests good stability of the niosomes on storage. Sorbitan esters produced the smallest niosomes of less than 400 nm diameter with a PDI less than 0.400 and an entrapment efficiency of more than 78% without cholesterol. The addition of cholesterol and DCP was essential to form niosomes with target CQA.
- Format
- computer
- Format
- online resource
- Format
- application/pdf
- Format
- 1 online resource (7 pages)
- Format
- Publisher
- Avoxa - Mediengruppe Deutscher Apotheker GmbH
- Language
- English
- Relation
- Die Pharmazie-An International Journal of Pharmaceutical Sciences
- Relation
- Witika, B.A. and Walker, R.B., 2021. Preformulation characterization and identification of excipients for nevirapine loaded niosomes. Die Pharmazie-An International Journal of Pharmaceutical Sciences, 76(2-3), pp.77-83
- Relation
- Die Pharmazie-An International Journal of Pharmaceutical Sciences volume 76 number 2-3 p. 77 2021 0031-7144
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Creative Commons CC BY-NC-ND 4.0 License (Attribution-NonCommercial-NoDerivatives 4.0 International) https://creativecommons.org/licenses/by-nc-nd/4.0/
- Rights
- Open Access
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Collections
Walker, Roderick Bryan (Prof)
RU Department of Pharmacy
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Preformulation characterization and identification of excipients for nevirapine loaded niosomes.pdf | 1 MB | Adobe Acrobat PDF | View Details Download |