- Title
- HPLC method for simultaneous analysis of ranitidine and metronidazole in dosage forms
- Creator
- King'ori, Loti D
- Creator
- Walker, Roderick B
- Subject
- To be catalogued
- Date Issued
- 2014
- Date
- 2014
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/184790
- Identifier
- vital:44272
- Identifier
- xlink:href="https://doi.org/10.14233/ajchem.2014.15432"
- Description
- A simple, rapid, precise and accurate stability indicating HPLC method for the simultaneous analysis of metronidazole and ranitidine in dosage forms has been developed and validated. Calibration curves for metronidazole and ranitidine exhibited linearity (R2 = 0.9995 for both compounds) over the concentration ranges investigated. The method was sensitive, selective and accurate for both compounds. Both drugs were found to be stable following acid hydrolysis studies. However, following alkali hydrolysis degradation of both compounds was observed. Furthermore metronidazole appeared to be stable following oxidative studies however ranitidine underwent complete degradation under these conditions. Both drugs were well resolved from the degradation products. The stability indicating chromatographic method has the necessary precision and accuracy for the simultaneous analysis of metronidazole and ranitidine in dosage forms.
- Format
- computer
- Format
- online resource
- Format
- application/pdf
- Format
- 1 online resource (5 pages)
- Format
- Publisher
- Asian Publication Corporation
- Language
- English
- Relation
- Asian Journal of Chemistry
- Relation
- King'ori, L.D. and Walker, R.B., 2014. HPLC method for simultaneous analysis of ranitidine and metronidazole in dosage forms. Asian Journal of Chemistry, 26(2), p.426
- Relation
- Asian Journal of Chemistry volume 26 number 2 p.426 2014 0970-7077
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Creative Commons CC BY 4.0 License (Attribution 4.0 International) https://creativecommons.org/licenses/by/4.0/
- Rights
- Open Access
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Collections
Walker, Roderick Bryan (Prof)
RU Department of Pharmacy
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | HPLC method for simultaneous analysis of ranitidine and metronidazole in dosage forms.pdf | 300 KB | Adobe Acrobat PDF | View Details Download |