- Title
- Drug transport mechanisms from carbopol/eudragit verapamil sustained-release tablets
- Creator
- Khamanga, Sandile M
- Creator
- Walker, Roderick B
- Subject
- To be catalogued
- Date Issued
- 2011
- Date
- 2011
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/184801
- Identifier
- vital:44273
- Identifier
- xlink:href="https://doi.org/10.14227/dt180311p30"
- Description
- The objectives of this study were to compare dissolution profiles of a verapamil (VRP) formulation manufactured inhouse and Isoptin SR using USP Apparatus 2 and 3 and to elucidate drug release kinetics of these dosage forms. Eudragit NE 30D (ethyl acrylate–methyl methacrylate copolymer in a 2:1 ratio) aqueous dispersion was used as a granulating binder for the manufacture of VRP mini-matrix sustained-release tablets. The wet granulation process was performed to prepare free-flowing granules that were blended with Carbopol. The tablets were manufactured using a single-punch press by compression of the granules with magnesium stearate as a lubricant. Drug release was determined in phosphate buffer solution using USP Apparatus 2 and 3. Dissolution data were fitted to zero- and first-order models; in addition, the kinetic data were determined by evaluation of Higuchi release kinetics. The mechanism of drug release was established using the Korsmeyer–Peppas model. In general, all tablets showed high mechanical resistance with less than 1% friability. There was no significant difference between the dissolution profiles of the formulation manufactured in-house and the commercially available product. The release mechanism of the formulated and marketed products was controlled by anomalous non-Fickian diffusion. VRP release was prolonged for 12 h indicating the usefulness of the formulation as a twice-daily dosage form. The mechanism of drug release for the dosage forms was unaffected by the choice of apparatus.
- Format
- computer
- Format
- online resource
- Format
- application/pdf
- Format
- 1 online resource (3 pages)
- Format
- Publisher
- Dissolution Technologies Inc.
- Language
- English
- Relation
- Dissolution Technologies
- Relation
- Khamanga, S. and Walker, R.B., 2011. Drug transport mechanisms from carbopol/eudragit verapamil sustained-release tablets. Dissolution Technologies, 18(3), pp.30-38
- Relation
- Dissolution Technologies volume 18 number 3 p.30 2011 1521-298X
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Dissolution Technologies Inc. Publishing Copyright and licensing Statement (http://dissolutiontech.com/DTresour/Pages/Submissionguides.html)
- Rights
- Open Access
- Hits: 800
- Visitors: 864
- Downloads: 66
Collections
Walker, Roderick Bryan (Prof)
Khamanga, Sandile S M (Assoc Prof)
RU Department of Pharmacy
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Drug transport mechanisms from carbopol eudragit verapamil sustained-release tablets (1).pdf | 379 KB | Adobe Acrobat PDF | View Details Download |