- Title
- The photophysicochemical properties and photodynamic therapy activity of Schiff base substituted phthalocyanines doped into silica nanoparticles and conjugated to folic acid
- Creator
- Magadla, Aviwe
- Creator
- Babu, Balaji
- Creator
- Sen, Pinar
- Creator
- Nyokong, Tebello
- Subject
- To be catalogued
- Date Issued
- 2021
- Date
- 2021
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/185407
- Identifier
- vital:44384
- Identifier
- xlink:href="https://doi.org/10.1016/j.poly.2021.115227"
- Description
- This work explores the synthesis, photophysicochemical properties and photodynamic activity (PDT) of tetrakis [N,N’–bis (4-(diethylamino)benzylidene) amino)propan-2-yl)oxy) phthalocyaninato] Zn (II) (3) and tetra-phenoxy N,N-dimethyl-4-((methylimino) Zn (II) (4) when the encapsulated into silica nanoparticles (SiNPs) followed by conjugation of folic acid (FA). The synthesised complexes and their doped analogues are examined for their PDT activity using MCF-7 cells. All the complexes showed dark toxicity that is >80%. The folic acid conjugates, MPc@SiNPs-FA showed greater photocytoxicity against MCF-7 cells upon irradiation with laser light.
- Format
- computer
- Format
- online resource
- Format
- application/pdf
- Format
- 1 online resource (10 pages)
- Format
- Publisher
- Elsevier
- Language
- English
- Relation
- Polyhedron
- Relation
- Magadla, A., Babu, B., Sen, P. and Nyokong, T., 2021. The photophysicochemical properties and photodynamic therapy activity of Schiff base substituted phthalocyanines doped into silica nanoparticles and conjugated to folic acid. Polyhedron, 203, p.115227
- Relation
- Polyhedron volume 203 p. 115227 2021 0277-5387
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
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Collections
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | The photophysicochemical properties and photodynamic therapy activity.pdf | 777 KB | Adobe Acrobat PDF | View Details Download | ||
| View Details Download | SOURCE2 | The photophysicochemical properties and photodynamic therapy activity of Schiff base substituted phthalocyanines doped into silica nanoparticles and conjugated to folic acid | 777 KB | Adobe Acrobat PDF | View Details Download |