- Title
- Photophysical properties and photodynamic therapy activity of a meso-tetra (4-carboxyphenyl) porphyrin tetramethyl ester–graphene quantum dot conjugate
- Creator
- Managa, Muthumuni
- Creator
- Ngoy, Bokolombe P
- Creator
- Nyokong, Tebello
- Subject
- To be catalogued
- Date Issued
- 2019
- Date
- 2019
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/187533
- Identifier
- vital:44669
- Identifier
- xlink:href="https://doi.org/10.1039/C8NJ06175K"
- Description
- Novel meso-tetra(4-carboxyphenyl)porphyrin tetramethyl ester metal derivatives were synthesised and characterized. These derivatives were interacted with graphene quantum dots (GDQs). Spectroscopic evidence that was obtained showed that the resultant conjugates were stable due to the strong π–π stacking interaction between the GQDs and the porphyrins. The fluorescence and singlet oxygen generating behaviour of the porphyrins and the nanoconjugates were investigated following incorporation. The dark toxicity and photodynamic therapy activities of the porphyrins and the nanoconjugates were successfully studied using MCF-7 breast cancer cells. Cell viability for the dark toxicity was more than 90% for all complexes. The PDT activities at the highest concentration of 120 μg ml−1 showed a decrease in cell viability down to 15.2% for the GaClTMPP–GQDs.
- Format
- computer
- Format
- online resource
- Format
- application/pdf
- Format
- 1 online resource (8 pages)
- Format
- Publisher
- Royal Society of Chemistry
- Language
- English
- Relation
- New Journal of Chemistry
- Relation
- Managa, M., Ngoy, B.P. and Nyokong, T., 2019. Photophysical properties and photodynamic therapy activity of a meso-tetra (4-carboxyphenyl) porphyrin tetramethyl ester–graphene quantum dot conjugate. New Journal of Chemistry, 43(11), pp.4518-4524
- Relation
- New Journal of Chemistry volume 43 number 11 p. 4518 2019 1369-9261
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Royal Society of Chemistry Terms and Conditions Statement (https://0-www.rsc.org.wam.seals.ac.za/help-legal/)
- Rights
- Open Access
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Collections
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
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