- Title
- Photodynamic antimicrobial chemotherapy activity of (5, 10, 15, 20-tetrakis (4-(4-carboxyphenycarbonoimidoyl) phenyl) porphyrinato) chloro gallium (III)
- Creator
- Managa, Muthumuni
- Creator
- Amuhaya, Edith K
- Creator
- Nyokong, Tebello
- Subject
- To be catalogued
- Date Issued
- 2015
- Date
- 2015
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/189043
- Identifier
- vital:44811
- Identifier
- xlink:href="https://doi.org/10.1016/j.saa.2015.06.088"
- Description
- (5,10,15,20-Tetrakis(4-(4-carboxyphenycarbonoimidoyl)phenyl)porphyrinato) chloro gallium(III) (complex 1) was conjugated to platinum nanoparticles (PtNPs) (represented as 1-PtNPs). The resulting conjugate showed 18 nm red shift in the Soret band when compared to 1 alone. Complex 1 and 1-PtNPs showed promising photodynamic antimicrobial chemotherapy (PACT) activity against Staphylococcus aureus, Escherichia coli and Candida albicans in solution where the log reductions obtained were 4.92, 3.76, and 3.95, respectively for 1-PtNPs. The singlet oxygen quantum yields obtained were higher at 0.56 for 1-PtNPs in DMF while that of 1 was 0.52 in the same solvent. This resulted in improved PACT activity for 1-PtNPs compared to 1 alone.
- Format
- computer
- Format
- online resource
- Format
- application/pdf
- Format
- 1 online resource (8 pages)
- Format
- Publisher
- Elsevier
- Language
- English
- Relation
- Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
- Relation
- Managa, M., Amuhaya, E.K. and Nyokong, T., 2015. Photodynamic antimicrobial chemotherapy activity of (5, 10, 15, 20-tetrakis (4-(4-carboxyphenycarbonoimidoyl) phenyl) porphyrinato) chloro gallium (III). Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 151, pp.867-874
- Relation
- Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy volume 151 p. 867 2015 1872-8014
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
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Collections
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Photodynamic antimicrobial chemotherapy activity.pdf | 824 KB | Adobe Acrobat PDF | View Details Download |