- Title
- Photodynamic antimicrobial action of asymmetrical porphyrins functionalized silver-detonation nanodiamonds nanoplatforms for the suppression of Staphylococcus aureus planktonic cells and biofilms
- Creator
- Openda, Yolande I
- Creator
- Ngoy, Bokolombe P
- Creator
- Nyokong, Tebello
- Subject
- To be catalogued
- Date Issued
- 2021
- Date
- 2021
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/190544
- Identifier
- vital:45004
- Identifier
- xlink:href="https://doi.org/10.3389/fchem.2021.628316"
- Description
- New asymmetrical porphyrin derivatives containing a p-hydroxyphenyl moiety and p-acetylphenyl moieties along with their functionalized silver-detonation nanodiamonds nanohybrids were characterized and their photophysicochemical properties were established. The study provides evidence that the metalated porphyrin derivatives were red-shifted in absorption wavelength and possessed high singlet oxygen quantum yield comparative to the unmetalated core, thus making them suitable agents for photodynamic antimicrobial chemotherapy. As a result of conjugation to detonation nanodiamonds and silver nanoparticles, these compounds proved to be more effective as they exhibited stronger antibacterial and anti-biofilm activities on the multi-drug resistant S. aureus strain due to synergetic effect, compared to Ps alone. This suggests that the newly prepared nanohybrids could be used as a potential antimicrobial agent in the treatment of biofilms caused by S. aureus strain.
- Format
- computer
- Format
- online resource
- Format
- application/pdf
- Format
- 1 online resource (17 pages)
- Format
- Publisher
- Frontiers Media
- Language
- English
- Relation
- Frontiers in Chemistry
- Relation
- Openda, Y.I., Ngoy, B.P. and Nyokong, T., 2021. Photodynamic antimicrobial action of asymmetrical porphyrins functionalized silver-detonation nanodiamonds nanoplatforms for the suppression of Staphylococcus aureus planktonic cells and biofilms. Frontiers in chemistry, 9, p.97
- Relation
- Frontiers in Chemistry volume 9 p. 97 2021 2296-2646
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Frontiers Terms and Conditions Statement (https://www.frontiersin.org/legal/terms-and-conditions)
- Rights
- Open Access
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Collections
Nyokong, Tebello (Distinguished Professor)
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
RU Department of Chemistry
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Photodynamic antimicrobial action of asymmetrical porphyrins functionalized silver-detonation.pdf | 3 MB | Adobe Acrobat PDF | View Details Download |