Synthesis and biological evaluation of bis-N2, N2′-(4-hydroxycoumarin-3-yl) ethylidene]-2, 3-dihydroxysuccinodihydrazides

Manyeruke, Meloddy H

Title: Synthesis and biological evaluation of bis-N2, N2′-(4-hydroxycoumarin-3-yl) ethylidene]-2, 3-dihydroxysuccinodihydrazides
Creator: Manyeruke, Meloddy H
Creator: Tshiwawa, Tendamudzimu
Creator: Hoppe, Heinrich C
Creator: Isaacs, Michelle
Creator: Seldon, Ronnett
Creator: Warner, Digby F
Creator: Krause, Rui W M
Creator: Kaye, Perry T
Subject: To be catalogued
Date Issued: 2020
Date: 2020
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/193430
Identifier: vital:45331
Identifier: xlink:href="https://doi.org/10.1016/j.bmcl.2019.126911"
Description: A series of N2,N2′-bis[4-hydroxycoumarin-3-yl)ethylidene]-2,3-dihydroxysuccino-hydrazides, containing 4-hydroxycoumarin, hydrazine and tartaric acid moieties, have been prepared and examined for possible biological activity. Several of these compounds exhibit promising HIV-1 integrase inhibition (IC50 = 3.5 μM), and anti-T. brucei (32% viability) and anti-mycobacterial (Visual MIC90 = 15.63 μM) activity.
Format: computer
Format: online resource
Format: application/pdf
Format: 1 online resource (4 pages)
Format: pdf
Publisher: Elsevier
Language: English
Relation: Bioorganic Medicinal Chemistry Letters
Relation: Manyeruke, M.H., Tshiwawa, T., Hoppe, H.C., Isaacs, M., Seldon, R., Warner, D.F., Krause, R.W. and Kaye, P.T., 2020. Synthesis and biological evaluation of bis-N2, N2′-(4-hydroxycoumarin-3-yl) ethylidene]-2, 3-dihydroxysuccinodihydrazides. Bioorganic and medicinal chemistry letters, 30(5), p.126911
Relation: Bioorganic Medicinal Chemistry Letters volume 30 number 5 p. 126911 2020 0960-894X
Rights: Publisher
Rights: Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
Rights: Closed Access

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Tshiwawa, Tendamudzimu (Dr)

Krause, Rui Werner Maçedo (Prof)

Hoppe, Heinrich C (Prof)

Isaacs, Michelle (Mrs)

Kaye, Perry T (Distinguished Fellow Emeritus Professor)

RU Department of Chemistry

SDG 03. Good Health and Well-Being

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