- Title
- The synergistic effects of coupling Au nanoparticles with an alkynyl Co (II) phthalocyanine on the detection of prostate specific antigen
- Creator
- Nxele, Siphesihle Robin
- Creator
- Nkhahle, Reitumetse
- Creator
- Nyokong, Tebello
- Subject
- To be catalogued
- Date Issued
- 2022
- Date
- 2022
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/230232
- Identifier
- vital:49756
- Identifier
- xlink:href="https://doi.org/10.1016/j.talanta.2021.122948"
- Description
- Prostate specific antigen (PSA) aptasensors are fabricated using a novel asymmetrically substituted Co phthalocyanine (CoPc), gold nanoparticles (AuNPs) and PSA-specific antigen. The fabricated aptasensors are: GCE-AuNPs-Aptamer, GCE@CoPc-Aptamer and GCE-AuNPs@CoPc-Aptamer (GCE = glassy carbon electrode). The fabricated sensors are characterized at each modification step to monitor the changes occurring at the sensor surface. Concentration studies were carried out using differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS) to determine detection limits. All the fabricated aptasensors were found to be highly specific and selective but the GCE-AuNPs@CoPc-Aptamer nanoconjugate performed the best. The aptasensors were also tested in spiked serum samples and detection limits, as well as % recoveries were determined. The results obtained showed that the GCE-AuNPs@CoPc-Aptamer has the potential to be used for clinical studies as the results agree with those obtained for detection of PSA in buffer.
- Format
- computer
- Format
- online resource
- Format
- application/pdf
- Format
- 1 online resource (9 pages)
- Format
- Publisher
- Elsevier
- Language
- English
- Relation
- Talanta
- Relation
- Nxele, S.R., Nkhahle, R. and Nyokong, T., 2022. The synergistic effects of coupling Au nanoparticles with an alkynyl Co (II) phthalocyanine on the detection of prostate specific antigen. Talanta, 237, p.122948
- Relation
- Talanta volume 237 p. 122948 2022 0039-9140
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
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Collections
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | The synergistic effects of coupling Au nanoparticles.pdf | 834 KB | Adobe Acrobat PDF | View Details Download |