- Title
- Synthesis and dark toxicity of 5-(4-carboxyphenyl)-10, 15, 20-tris (phenyl)-porphyrinato chlorido gallium (III) when conjugated to δ-aminolevulinic acid
- Creator
- Managa, Muthumuni
- Creator
- Mkhize, Scebi
- Creator
- Britton, Jonathan
- Creator
- Prinsloo, Earl
- Creator
- Nyokong, Tebello
- Subject
- To be catalogued
- Date Issued
- 2016
- Date
- 2016
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/240014
- Identifier
- vital:50789
- Identifier
- xlink:href="https://doi.org/10.1080/00958972.2016.1223292"
- Description
- 5-(4-Carboxyphenyl)-10,15,20-tris(phenyl)-porphyrinato chlorido gallium(III) (2) was synthesized and then linked to ethyl ester δ-aminolevulinic acid to form 3. There was no shift in Soret band following conjugation. The fluorescence and singlet oxygen generating behavior of the porphyrins were also investigated. The highest singlet oxygen quantum yield (ΦΔ) obtained was that of 3. Complexes 2 and 3 as well as metal free 5-(4-carboxyphenyl)-10,15,20-tris(phenyl)-porphyrinato showed no dark toxicity on MCF-7 breast cancer cells.
- Format
- computer
- Format
- online resource
- Format
- application/pdf
- Format
- 1 online resource (9 pages)
- Format
- Publisher
- Taylor and Francis Online
- Language
- English
- Relation
- Journal of Coordination Chemistry
- Relation
- Managa, M., Mkhize, S., Britton, J., Prinsloo, E. and Nyokong, T., 2016. Synthesis and dark toxicity of 5-(4-carboxyphenyl)-10, 15, 20-tris (phenyl)-porphyrinato chlorido gallium (III) when conjugated to δ-aminolevulinic acid. Journal of Coordination Chemistry, 69(20), pp.3035-3042
- Relation
- Journal of Coordination Chemistry volume 69 number 20 p. 3035 2016 1029-0389
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Taylor and Francis Online Terms and Conditions Statement (https://www.tandfonline.com/terms-and-conditions)
- Rights
- Open Access
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Collections
Prinsloo, Earl (Dr)
Britton, Jonathan (Dr)
Nyokong, Tebello (Distinguished Professor)
RU DST/NRF SARChI for Biotechnology Innovation and Engagement
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
RU Department of Chemistry
SDG 03. Good Health and Well-Being
SDG 09. Industry, Innovation and Infrastructure
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Synthesis and dark toxicity (1).pdf | 1 MB | Adobe Acrobat PDF | View Details Download |