- Title
- Photodynamic therapy effect of zinc monoamino phthalocyanine–folic acid conjugate adsorbed on single walled carbon nanotubes on melanoma cells
- Creator
- Ogbodu, Racheal O
- Creator
- Ndhundhuma, Ivy
- Creator
- Karstten, Aletta
- Creator
- Nyokong, Tebello
- Subject
- To be catalogued
- Date Issued
- 2015
- Date
- 2015
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/241400
- Identifier
- vital:50936
- Identifier
- xlink:href="https://doi.org/10.1016/j.saa.2014.09.033"
- Description
- This work reports on the photodynamic therapy effect of zinc monoamino phthalocyanine linked to folic acid represented as ZnMAPc-FA, which was further immobilized onto single walled carbon nanotube represented as ZnMAPc-FA-SWCNT on melanoma A375 cell line, the effect of SWCNT-FA (without ZnMAPc) was also examined. All the compounds were non-toxic to the melanoma A375 cell line in the absence of light. Upon irradiation of the melanoma A375 cell line with a 676 nm diode laser at a power density of 98 mW/cm2 at 5 J/cm2 about 60% and 63% cell death was observed in the presence of ZnMAPc-FA and ZnMAPc-FA-SWCNT respectively. SWCNT-FA had no significant photodynamic therapy or photothermal effect to the cell, only 23% of cell death was observed after irradiation.
- Format
- computer
- Format
- online resource
- Format
- application/pdf
- Format
- 1 online resource (6 pages)
- Format
- Publisher
- Elsevier
- Language
- English
- Relation
- Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
- Relation
- Ogbodu, R.O., Ndhundhuma, I., Karsten, A. and Nyokong, T., 2015. Photodynamic therapy effect of zinc monoamino phthalocyanine–folic acid conjugate adsorbed on single walled carbon nanotubes on melanoma cells. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 137, pp.1120-1125
- Relation
- Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy volume 137 p. 1120 2015 1386-1425
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
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RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Photodynamic therapy effect of zinc monoamino phthalocyanine–folic acid.pdf | 873 KB | Adobe Acrobat PDF | View Details Download |