- Title
- Synthesis and photophysical properties of a novel zinc photosensitizer and its gold nanoparticle conjugate
- Creator
- Moeno, Sharon
- Creator
- Antunes, Edith M
- Creator
- Nyokong, Tebello
- Subject
- To be catalogued
- Date Issued
- 2011
- Date
- 2011
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/247100
- Identifier
- vital:51546
- Identifier
- xlink:href="https://doi.org/10.1016/j.jphotochem.2011.07.007"
- Description
- The peripherally tetra substituted zinc phthalocyanine with 1,6-hexanedithiol as substituent (THdTZnPc, 3) was synthesized and is reported for the first time in this work. The potential of this zinc complex as a suitable photosensitizer for use in photodynamic therapy was determined through the investigation of the photophysical and photochemical properties. In this work complex 3 is attached to gold nanoparticles through the terminal thiol groups of the phthalocyanine resulting in a 3-AuNP conjugate whose photophysicochemical properties are investigated. Fluorescence lifetimes were determined using time correlated single photon counting and they show an increase in the abundance of the monomeric species (τ2) for the Pc in the 3-AuNP conjugate: ∼1 and 0.71 (with respective lifetimes 2.69 ns and 2.86 ns) compared to the free complex 3 with abundances of 0.12 and 0.13 (with respective lifetimes 3.36 ns and 3.28 ns) in DMSO and DMF, respectively.
- Format
- computer
- Format
- online resource
- Format
- application/pdf
- Format
- 1 online resource (8 pages)
- Format
- Publisher
- Elsevier
- Language
- English
- Relation
- Journal of Photochemistry and Photobiology A: Chemistry
- Relation
- Moeno, S., Antunes, E. and Nyokong, T., 2011. Synthesis and photophysical properties of a novel zinc photosensitizer and its gold nanoparticle conjugate. Journal of Photochemistry and Photobiology A: Chemistry, 222(2-3), pp.343-350
- Relation
- Journal of Photochemistry and Photobiology A: Chemistry volume 222 number 2 - 3 p. 343 2011 1873-2666
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
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Antunes, Edith Martins (Dr)
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
SDG 03. Good Health and Well-Being
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