- Title
- Interaction of the neurotransmitter acetylcholine with aluminium, calcium and sodium
- Creator
- Matlaba, Pulane M
- Creator
- Daya, Santy
- Creator
- Nyokong, Tebello
- Subject
- To be catalogued
- Date Issued
- 2000
- Date
- 2000
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/293246
- Identifier
- vital:57068
- Identifier
- xlink:href="https://doi.org/10.1211/146080800128735890"
- Description
- Binding of aluminium to acetylcholine has important biological implications particularly in Alzheimer's disease. An electrochemical technique, adsorptive cathodic stripping voltammetry, has been employed in this study to investigate the in-situ formation of a complex between aluminium and acetylcholine. The stability of the resulting complex was compared with that of the in-situ complexes formed between acetylcholine and sodium or calcium. From the shifts in the reduction potential of the metals on addition of acetylcholine it is concluded that a strong complex is formed between acetylcholine and aluminium. Much weaker complexes are formed between calcium or sodium and acetylcholine. These results have important implications in the aetiology of Alzheimer's disease-in which brain aluminium concentrations are known to be high and brain cholinergic function is lower than normal.
- Format
- computer
- Format
- online resource
- Format
- application/pdf
- Format
- 1 online resource (5 pages)
- Format
- Publisher
- Wiley Library Online
- Language
- English
- Relation
- Pharmacy and Pharmacology Communications
- Relation
- Matlaba, P., Daya, S. and Nyokong, T., 2000. Interaction of the neurotransmitter acetylcholine with aluminium, calcium and sodium. Pharmacy and Pharmacology Communications, 6(5), pp.201-205
- Relation
- Pharmacy and Pharmacology Communications volume 6 number 5 p. 201 2000 1460-8081
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Wiley Library Online Terms of Use Statement (https://onlinelibrary.wiley.com/terms-and-conditions)
- Rights
- Closed Access
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Collections
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
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