- Title
- The effect of charge on Zn tetra morpholine porphyrin conjugated to folic acid-nitrogen doped graphene quantum dots for photodynamic therapy studies
- Creator
- Magaela, N Bridged
- Creator
- Matshitse, Refilwe
- Creator
- Nyokong, Tebello
- Subject
- To be catalogued
- Date Issued
- 2022
- Date
- 2022
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/295840
- Identifier
- vital:57383
- Identifier
- xlink:href="https://doi.org/10.1016/j.pdpdt.2022.102898"
- Description
- Zinc tetra morpholine porphyrin (complex 2), and its quaternized derivative (complex 3) were synthesized and conjugated to folic acid decorated nitrogen doped graphene quantum dots (FA-NGQDs) through π−π stacking to study their photodynamic therapy (PDT) efficacy. Photophysiochemical properties of complexes 2, 3, and their conjugates (2-FA-NGQDs, 3-FA-NGQDs) were studied. It was found that complex 3 had higher ϕΔ of 0.56 compared to complex 2 with ϕΔ of 0.24, and respective composites: 3-FA-NGQDs had higher ϕΔ compared to 2-FA-NGQDs. The PDT studies were conducted for nanoparticles (FA-NGQDs), complexes (2, 3), and respective composites (2-FA-NGQDs, and 3-FA-NGQDs) using MCF-7 breast cancer cell. Dark toxicity of all compounds was above 90% which is negligible. At a highest concentration of 40 µg/mL, 3-FA-NGQDs gave the lowest cell viability of 28% compared to all other conjugates and porphyrins alone.
- Format
- computer
- Format
- online resource
- Format
- application/pdf
- Format
- 1 online resource (15 pages)
- Format
- Publisher
- Elsevier
- Language
- English
- Relation
- Photodiagnosis and Photodynamic Therapy
- Relation
- Magaela, N.B., Matshitse, R. and Nyokong, T., 2022. The effect of charge on Zn tetra morpholine porphyrin conjugated to folic acid-nitrogen doped graphene quantum dots for photodynamic therapy studies. Photodiagnosis and Photodynamic Therapy, p.102898
- Relation
- Photodiagnosis and Photodynamic Therapy p. 102898 2022 1873-1597
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
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Collections
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
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