- Title
- Photodynamic therapy activity of 5, 10, 15-tris (5-bromo-2-thienyl), 20 (phenylcarboxy) porphyrin conjugated to graphene quantum dot against MCF-7 breast cancer cells
- Creator
- Makola, Lekgowa Collen
- Creator
- Nwahahra, Nnamdi
- Creator
- Managa, Muthumuni
- Creator
- Nyokong, Tebello
- Subject
- To be catalogued
- Date Issued
- 2022
- Date
- 2022
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/300244
- Identifier
- vital:57909
- Identifier
- xlink:href="https://doi.org/10.1080/00958972.2022.2087515"
- Description
- A novel 5,10,15-tris(5-bromo-2-thienyl),20(phenylcarboxy)porphyrin and its gallium derivative have been synthesized and fully characterized by various spectroscopic techniques and their respective photophysical and photochemical properties, such as the singlet oxygen quantum yield (ΦΔ), fluorescence quantum yield (ΦF) and triplet lifetime (τT) were determined. The complexes were conjugated to PEI_GQDs resulting is stable conjugates, owing to strong π–π stacking interaction between the PEI_GQDs and the porphyrins. PDT studies were carried out on these nanoconjugates and results obtained indicated they are suitable candidates for further in-depth PDT studies.
- Format
- computer
- Format
- online resource
- Format
- application/pdf
- Format
- 1 online resource (17 pages)
- Format
- Publisher
- Taylor and Francis Online
- Language
- English
- Relation
- Journal of Coordination Chemistry
- Relation
- Makola, L.C., Nwahara, N., Managa, M. and Nyokong, T., 2022. Photodynamic therapy activity of 5, 10, 15-tris (5-bromo-2-thienyl), 20 (phenylcarboxy) porphyrin conjugated to graphene quantum dot against MCF-7 breast cancer cells. Journal of Coordination Chemistry, 75(7-8), pp.1112-1128
- Relation
- Journal of Coordination Chemistry volume 75 number 7 - 8 p. 1112 2022 1029-0389
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Taylor and Francis Online Terms and Conditions Statement (https://www.tandfonline.com/terms-and-conditions)
- Rights
- Open Access
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Collections
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
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