- Title
- The human skin-blanching assay for comparing topical corticosteroid availability
- Creator
- Smith, Eric W
- Creator
- Meyer, Eric
- Creator
- Haigh, John M
- Creator
- Maibach, Harold I
- Date Issued
- 1991
- Date
- 1991
- Type
- Article
- Identifier
- vital:6433
- Identifier
- http://hdl.handle.net/10962/d1006604
- Description
- The human skin blanching assay remains in widespread use as a reliable, qualitative, comparative indicator of topical corticosteroid availability and potency. The experimental refinements promulgated by certain researchers in this field have yielded a versatile bioassay for the accurate assessment of new drugs or delivery vehicles. With the increasing appearance of generic topical corticosteroid formulations which compete with trade-name equivalents, the vital importance of this assay in regulatory affairs and assessing bioequivalence has been re-emphasized. It is stressed that if the blanching assay is to be used in this sphere, then multiple-reading trials must be conducted; important registration or clinical decisions cannot be made with any validity from short-term assessments.
- Format
- 4 pages
- Format
- Language
- English
- Relation
- Smith, E.W. and Meyer, E. and Haigh, J.M. and Maibach, H.I. (1991) The human skin-blanching assay for comparing topical corticosteroid availability. Journal of Dermatological Treatment, 2 . pp. 69-72.
- Hits: 711
- Visitors: 933
- Downloads: 243
Thumbnail | File | Description | Size | Format | |||
---|---|---|---|---|---|---|---|
View Details Download | SOURCEPDF | 2 MB | Adobe Acrobat PDF | View Details Download |