The human skin-blanching assay as an indicator of topical corticosteroid bioavailability and potency: an update

Title: The human skin-blanching assay as an indicator of topical corticosteroid bioavailability and potency: an update
Creator: Smith, Eric W
Creator: Meyer, Eric
Creator: Haigh, John M
Creator: Maibach, Harold I
Date Issued: 1989
Date: 1989
Type: Book chapter
Identifier: vital:6440
Identifier: http://hdl.handle.net/10962/d1006627
Identifier: ISBN 0824780361
Description: The human skin-blanching (or vasoconstrictor) assay has evolved from initial observations that corticosteroids induce a pallor or whitening of the skin to which they are applied. McKenzie and Stoughton (1962) are generally recognized as having developed the first scientific bioassay for comparing corticosteroid potency. The extensive use of this bioassay to compare drug release from topical delivery systems has demonstrated numerous instances in which the topical bioavailability may vary greatly, dependent on the character of the delivery vehicle. It has become evident that simply incorporating an intrinsically potent drug into a formulation does not necessarily produce a clinically efficacious product.
Format: 18 pages
Format: pdf
Language: English
Relation: Smith, E.W. and Meyer, E. and Haigh, J.M. and Maibach, H.I. (1989) The human skin-blanching assay as an indicator of topical corticosteroid bioavailability and potency: an update. In: Percutaneous absorption : mechanisms - methodology - drug delivery. Marcel Dekker, New York, pp. 443-460.

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