The TPR2B domain of the Hsp70/Hsp90 organizing protein (Hop) may contribute towards its dimerization

Title: The TPR2B domain of the Hsp70/Hsp90 organizing protein (Hop) may contribute towards its dimerization
Creator: Longshaw, Victoria M
Creator: Stephens, Linda L
Creator: Daniel, Sheril
Creator: Blatch, Gregory L
Date Issued: 2009
Date: 2009
Type: Article
Identifier: vital:6481
Identifier: http://hdl.handle.net/10962/d1006253
Identifier: http://dx.doi.org/10.2174/092986609787848162
Description: The role of the TPR2B domain of Hop is as yet unknown. We have shown here by site directed mutagenesis and size exclusion chromatography for the first time that the TPR1 and TPR2B domains of Hop independently dimerized, and that the dimerization of TPR2B was not dependent on its predicted two-carboxylate clamp residues. Furthermore, our data indicated that the dimerization of Hop and its domains was not disrupted in the presence of Hsp70 and Hsp90 peptides.
Format: 21 pages
Format: pdf
Language: English
Relation: Longshaw, V.M. and Stephens, L.L. and Daniel, S. and Blatch, G.L. (2009) The TPR2B domain of the Hsp70/Hsp90 organizing protein (Hop) may contribute towards its dimerization. Protein and Peptide Letters, 16 (4). pp. 402-407. Available: http://dx.doi.org/10.2174/092986609787848162

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