The structural and functional diversity of Hsp70 proteins from Plasmodium falciparum

Shonhai, Addmore; Boshoff, Aileen; Blatch, Gregory L

Title: The structural and functional diversity of Hsp70 proteins from Plasmodium falciparum
Creator: Shonhai, Addmore
Creator: Boshoff, Aileen
Creator: Blatch, Gregory L
Date Issued: 2007
Date: 2007
Type: Article
Identifier: vital:6486
Identifier: http://hdl.handle.net/10962/d1006269
Identifier: http://dx.doi.org/10.1110/ps.072918107
Description: It is becoming increasingly apparent that heat shock proteins play an important role in the survival of Plasmodium falciparum against temperature changes associated with its passage from the cold-blooded mosquito vector to the warm-blooded human host. Interest in understanding the possible role of P. falciparum Hsp70s in the life cycle of the parasite has led to the identification of six HSP70 genes. Although most research attention has focused primarily on one of the cytosolic Hsp70s (PfHsp70-1) and its endoplasmic reticulum homolog (PfHsp70-2), further functional insights could be inferred from the structural motifs exhibited by the rest of the Hsp70 family members of P. falciparum. There is increasing evidence that suggests that PfHsp70-1 could play an important role in the life cycle of P. falciparum both as a chaperone and immunogen. In addition, P. falciparum Hsp70s and Hsp40 partners are implicated in the intracellular and extracellular trafficking of proteins. This review summarizes data emerging from studies on the chaperone role of P. falciparum Hsp70s, taking advantage of inferences gleaned from their structures and information on their cellular localization. The possible associations between P. falciparum Hsp70s with their cochaperone partners as well as other chaperones and proteins are discussed.
Format: 17 pages
Format: pdf
Language: English
Relation: Shonhai, A. and Boshoff, A. and Blatch, G.L. (2007) The structural and functional diversity of Hsp70 proteins from Plasmodium falciparum. Protein Science, 16 (9). pp. 1803-1818. Available: http://dx.doi.org/10.1110/ps.072918107

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Boshoff, Aileen (Assoc Prof)

RU Department of Biochemistry, Microbiology and Bioinformatics

SDG 03. Good Health and Well-Being

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