- Title
- Co phthalocyanine mediated electrochemical detection of the HER2 in the presence of Au and CeO2 nanoparticles and graphene quantum dots
- Creator
- Centane, Sixolile
- Creator
- Nyokong, Tebello
- Subject
- To be catalogued
- Date Issued
- 2023
- Date
- 2023
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/360372
- Identifier
- vital:65083
- Identifier
- xlink:href="https://doi.org/10.1016/j.bioelechem.2022.108301"
- Description
- In this work, cobalt tetra phenoxy acetic acid phthalocyanine (CoTAPc) is investigated as an electron mediator, immobilization platform for an HB5 aptamer and to enhance the electrochemical signal for the detection of human epidermal growth factor receptor 2 (HER2). Furthermore, the CoTAPc was combined individually with sulphur/nitrogen doped graphene quantum dots (SNGQDs), gold nanoparticles (AuNPs) and cerium oxide nanoparticles (CeO2NPs), on a glassy carbon electrode (GCE) via sequential adsorption. The CoTAPc and SNGQDs were also π-π stacked, used for electrode modification similarly to the rest of the other surfaces and applied towards the electrochemical detection of HER2. The designed sensors were characterized using electrochemical impedance spectroscopy (EIS). The designed aptasensors showed detection limits as low as 6.0 pg/mL. The real life applicability of the designed aptasensors was tested in human serum samples. The aptasensors showed great storage stability, sensitivity and specificity towards HER2, implying great potential for applications in early diagnosis of breast cancer.
- Format
- computer
- Format
- online resource
- Format
- application/pdf
- Format
- 1 online resource (12 pages)
- Format
- Publisher
- Elsevier
- Language
- English
- Relation
- Bioelectrochemistry
- Relation
- Centane, S. and Nyokong, T., 2023. Co phthalocyanine mediated electrochemical detection of the HER2 in the presence of Au and CeO2 nanoparticles and graphene quantum dots. Bioelectrochemistry, 149, p.108301
- Relation
- Bioelectrochemistry volume 149 p. 108301 2023 1567-5394
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
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RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Co phthalocyanine mediated electrochemical detection of the HER2.pdf | 831 KB | Adobe Acrobat PDF | View Details Download |