Photodynamic therapy effect of zinc monoamino phthalocyanine–folic acid conjugate adsorbed on single walled carbon nanotubes on melanoma cells

Ogbodu, Racheal O; Ndhundhuma, Ivy; Karsten, Aletta; Nyokong, Tebello

Title: Photodynamic therapy effect of zinc monoamino phthalocyanine–folic acid conjugate adsorbed on single walled carbon nanotubes on melanoma cells
Creator: Ogbodu, Racheal O
Creator: Ndhundhuma, Ivy
Creator: Karsten, Aletta
Creator: Nyokong, Tebello
Type: Article
Identifier: vital:7273
Identifier: http://hdl.handle.net/10962/d1020288
Description: This work reports on the photodynamic therapy effect of zinc monoamino phthalocyanine linked to folic acid represented as ZnMAPc-FA, which was further immobilized onto single walled carbon nanotube represented as ZnMAPc-FA-SWCNT on melanoma A375 cell line, the effect of SWCNT-FA (without ZnMAPc) was also examined. All the compounds were non-toxic to the melanoma A375 cell line in the absence of light. Upon irradiation of the melanoma A375 cell line with a 676 nm diode laser at a power density of 98 mW/cm2 at 5 J/cm2 about 60% and 63% cell death was observed in the presence of ZnMAPc-FA and ZnMAPc-FA-SWCNT respectively. SWCNT-FA had no significant photodynamic therapy or photothermal effect to the cell, only 23% of cell death was observed after irradiation.
Description: Original publication is available at http://dx.doi.org/10.1016/j.saa.2014.09.033
Format: 6 p
Format: pdf
Language: English
Relation: Ogbodu, R. O., Ndhundhuma, I., Karsten, A. & Nyokong, T. 2015. Photodynamic therapy effect of zinc monoamino phthalocyanine–folic acid conjugate adsorbed on single walled carbon nanotubes on melanoma cells. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 137:1120–1125. Available: http://dx.doi.org/10.1016/j.saa.2014.09.033.

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Nyokong, Tebello (Distinguished Professor)