- Title
- Synthesis and evaluation of phosphonated N-heteroarylcarboxamides as DOXP-reductoisomerase (DXR) inhibitors
- Creator
- Bodill, Taryn
- Creator
- Conibear, Anne C
- Creator
- Blatch, Gregory L
- Creator
- Lobb, Kevin A
- Creator
- Kaye, Perry T
- Subject
- To be catalogued
- Date Issued
- 2011
- Date
- 2011
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/448939
- Identifier
- vital:74772
- Identifier
- xlink:href="https://doi.org/10.1016/j.bmc.2010.11.062"
- Description
- The diethyl esters and disodium salts of a range of heteroarylcarbamoylphosphonic acids have been prepared and evaluated as analogues of the highly active DOXP-reductoisomerase (DXR) inhibitor, fosmidomycin. Computer-simulated docking studies, Saturation Transfer Difference (STD) NMR analysis and enzyme inhibition assays have been used to explore enzyme-binding and -inhibition potential, while in silico analysis of the DXR active site has highlighted the importance of including a well-parameterised metal co-factor in docking studies and has revealed the availability of an additional binding pocket to guide future drug design.
- Format
- computer
- Format
- online resource
- Format
- application/pdf
- Format
- 1 online resource (7 pages)
- Format
- Publisher
- Elsevier
- Language
- English
- Relation
- Bioorganic and Medicinal Chemistry
- Relation
- Bodill, T., Conibear, A.C., Blatch, G.L., Lobb, K.A. and Kaye, P.T., 2011. Synthesis and evaluation of phosphonated N-heteroarylcarboxamides as DOXP-reductoisomerase (DXR) inhibitors. Bioorganic and medicinal chemistry, 19(3), pp.1321-1327
- Relation
- Bioorganic and Medicinal Chemistry volume 19 number 3 p. 1321 2011 0968-0896
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
- Hits: 83
- Visitors: 81
- Downloads: 4
Collections
Blatch, Gregory Lloyd (Prof)
RU Centre for Chemico- and Biomedicinal Research (CCBR)
Lobb, Kevin Allan (Assoc Prof)
Kaye, Perry T (Distinguished Fellow Emeritus Professor)
RU Department of Chemistry
RU Department of Biochemistry, Microbiology and Bioinformatics
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Synthesis and evaluation of phosphonated N-heteroarylcarboxamides as DOXP-reductoisomerase (DXR) inhibitors.pdf | 688 KB | Adobe Acrobat PDF | View Details Download |