Rational design and regioselective synthesis of conformationally restricted furan-derived ligands as potential anti-malarial agents

Mutorwa, Marius K; Nokalipa, Iviwe C; Tanner, Delia C; Blatch, Gregory L; Lobb, Kevin A; Klein, Rosalyn; Kaye, Perry T

Title: Rational design and regioselective synthesis of conformationally restricted furan-derived ligands as potential anti-malarial agents
Creator: Mutorwa, Marius K
Creator: Nokalipa, Iviwe C
Creator: Tanner, Delia C
Creator: Blatch, Gregory L
Creator: Lobb, Kevin A
Creator: Klein, Rosalyn
Creator: Kaye, Perry T
Subject: To be catalogued
Date Issued: 2020
Date: 2020
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/477650
Identifier: vital:78108
Identifier: xlink:href="https://doi.org/10.24820/ark.5550190.p011.281"
Description: Substituted 3-furanomethyl phosphate esters and their corresponding phosphoric acids have been prepared as conformationally restricted analogues of DOXP, the natural substrate for Plasmodium falciparum 1-deoxyD-xylulose-5-phosphate reductoisomerase (PfDXR), and fosmidomycin, an established inhibitor. Saturation Transfer Difference (STD) NMR analysis and in silico docking data suggest the potential of such compounds as PfDXR inhibitors.
Format: computer
Format: online resource
Format: application/pdf
Format: 1 online resource (16 pages)
Format: pdf
Publisher: Archive for Organic Chemistry
Language: English
Relation: Organic Chemistry
Relation: Mutorwa, M.K., Nokalipa, I., Tanner, D.C., Blatch, G.L., Lobb, K.A., Klein, R. and Kayea, P.T., 2020. Rational design and regioselective synthesis of conformationally restricted furan-derived ligands as potential anti-malarial agents. Organic Chemistry, (part iii), pp. 136-151
Relation: Organic Chemistry volume 3 p. 136 2020 1090-2120
Rights: Publisher
Rights: This paper is an open access article distributed under the terms of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
Rights: Open Access

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Klein, Rosalyn (Assoc Prof)

Blatch, Gregory Lloyd (Prof)

Kaye, Perry T (Distinguished Fellow Emeritus Professor)

Lobb, Kevin Allan (Assoc Prof)

RU Department of Chemistry

SDG 03. Good Health and Well-Being

RU Department of Biochemistry, Microbiology and Bioinformatics

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