Synthesis and characterization of novel zinc phthalocyanines as potential photosensitizers for photodynamic therapy of cancers

Moeno, Sharon; Ermilov, E A; Kuzyniak, W; Höpfner, M; Krause, Rui W M

Title: Synthesis and characterization of novel zinc phthalocyanines as potential photosensitizers for photodynamic therapy of cancers
Creator: Moeno, Sharon
Creator: Ermilov, E A
Creator: Kuzyniak, W
Creator: Höpfner, M
Creator: Krause, Rui W M
Date Issued: 2014
Date: 2014
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/123673
Identifier: vital:35471
Identifier: https://doi.org/10.1039/C3PP50393C
Description: Two novel zinc phthalocyanines (Pcs): tetramethyl tetrakis-2,(3)-[(4-methyl-2-pyridyloxy)phthalocyaninato] zinc(II) (4) and (the negatively charged form) tetrakis-2,(3)-[(3-carboxylicacid-6-sulfanylpyridine)phthalocyaninato] zinc(II) (5), water soluble by virtue of their ionic substituent groups were synthesized. The spectroscopic properties of both compounds were determined and their photodynamic activities were investigated in a human tumor cell model. In aqueous media the two peripherally substituted water soluble Pcs are highly aggregated. The phototoxic activity of the two novel Pcs (Pc 4 and Pc 5; 0–20 μM) was shown to be time- and dose-dependent in human pancreatic carcinoid BON cells, leading to a reduction of tumor cells of >80% compared to the controls. The effectiveness of the treatment appeared to be attenuated by the aggregation of Pcs under aqueous conditions. Interestingly, even those cells that were not immediately killed by the photoactivated photosensitizer seemed to be affected by the Pc photodynamic activity, as a single PDT induced long-lasting effects on cell survival. Even 4 days after PDT, the number of surviving cells did not re-increase or still dropped, as compared to control cells. The underlying mechanism of this observation has to be deciphered in future investigations.
Format: 7 pages
Format: pdf
Language: English
Relation: Photochemical and Photobiological Sciences
Relation: Moeno, S., Krause, R.W.M., Ermilov, E.A., Kuzyniak, W. and Höpfner, M., 2014. Synthesis and characterization of novel zinc phthalocyanines as potential photosensitizers for photodynamic therapy of cancers. Photochemical and Photobiological Sciences, 13(6), pp.963-970.
Relation: Photochemical and Photobiological Sciences number 13 963 970 2014 1474-9092
Rights: Photochemical and Photobiological Sciences
Rights: Use of this resource is governed by the terms and conditions of the Royal Society of Chemistry Terms and Conditions Statement (http://www.rsc.org/help-legal/)

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Krause, Rui Werner Maçedo (Prof)

RU Department of Chemistry

SDG 03. Good Health and Well-Being

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