- Title
- Novobiocin–ferrocene conjugates possessing anticancer and antiplasmodial activity independent of HSP90 inhibition.
- Creator
- Mbaba, Mziyanda
- Creator
- de la Mare, Jo-Anne
- Creator
- Sterrenberg, Jason N
- Creator
- Kajewole, Deborah
- Creator
- Maharaj, Shantal
- Creator
- Edkins, Adrienne L
- Creator
- Isaacs, Michelle
- Creator
- Hoppe, Heinrich C
- Creator
- Khanye, Setshaba D
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/122858
- Identifier
- vital:35359
- Identifier
- https://doi.org/10.1007/s00775-018-1634-9
- Description
- A series of tailored novobiocin–ferrocene conjugates was prepared in moderate yields and investigated for in vitro anticancer and antiplasmodial activity against the MDA-MB-231 breast cancer line and Plasmodium falciparum 3D7 strain, respectively. While the target compounds displayed moderate anticancer activity against the breast cancer cell line with IC50 values in the mid-micromolar range, compounds 10a–c displayed promising antiplasmodial activity as low as 0.889 µM. Furthermore, the most promising compounds were tested for inhibitory effects against a postulated target, heat shock protein 90 (Hsp90).
- Format
- 10 pages
- Format
- Language
- English
- Relation
- JBIC Journal of Biological Inorganic Chemistry
- Relation
- Mbaba, M., de la Mare, J.A., Sterrenberg, J.N., Kajewole, D., Maharaj, S., Edkins, A.L., Isaacs, M., Hoppe, H.C. and Khanye, S.D., 2019. Novobiocin–ferrocene conjugates possessing anticancer and antiplasmodial activity independent of HSP90 inhibition. JBIC Journal of Biological Inorganic Chemistry, 24(2), pp.139-149.
- Relation
- JBIC Journal of Biological Inorganic Chemistry number 24 139 149 2018 1432-1327
- Rights
- JBIC Journal of Biological Inorganic Chemistry
- Rights
- Use of this resource is governed by the SpringerLink Terms of Use Statement (https://link.springer.com/termsandconditions)
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Collections
De la Mare, Jo-Anne (Dr)
Edkins, Adrienne Lesley (Associate Prof)
Khanye, David Setshaba (Associate Prof)
RU Centre for Chemico- and Biomedicinal Research (CCBR)
Hoppe, Heinrich C (Prof)
Isaacs, Michelle (Mrs)
RU Department of Pharmacy
RU Department of Biochemistry, Microbiology and Bioinformatics
SDG 03. Good Health and Well-Being
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