An assessment of the management of the quality of Education and its impact on Learners’ academic performance in selected Schools in Mthatha, South Africa
- Authors: Kariyana, Israel
- Date: 2015
- Subjects: Quality education -- Schools -- South Africa Academic performance -- Learners -- South Africa -- Mthatha School management – Teaching and learning School management team (SMT)
- Language: English
- Type: Thesis , Doctoral , D Ed
- Identifier: http://hdl.handle.net/11260/1302 , vital:30800
- Description: The study sought to assess the impact on learners‘ academic performance of the management of the quality of education in South African schools. The study was conducted in ten independent and ten public schools in Mthatha. The study elicited information for quantitative data from 60 school management team (SMT) members, 200 educators and 400 learners who were randomly sampled from the participating purposively sampled schools. Qualitative data and document analysis were used to triangulate quantitative findings. Data collected was coded and analysed thematically. Quantitative data were analysed with the aid of the SPSS version 22 and qualitative data were analysed through content analysis. Quantitative data were presented through a blend of both descriptive and inferential statistics using tables and graphs. The study found that school management teams (SMTs) and educators were more aware than learners that there are national and provincial legislation mandates that guide the management of quality in education. However, stakeholders were of the view that schools did not use relevant national, provincial and school-based policies and procedures to guide the provision and management of quality in education. It also emerged that learners did not conduct themselves in a manner that promoted the provision of quality education. Participants were, nevertheless agreeable on the indicators of high-quality education. SMTs and educators held stronger views than learners about schools having clear vision and mission statements (VMS) in place but neither were displayed for all to see nor were they well known to and supported by the ii SMTs, educators and learners, thus they were not implemented. The study also established that respondents were aware of the educator-centred, SMT-centred as well as learner-centred factors that affected the quality of education and that factors that promote high-quality education were largely absent in schools. Stakeholders also agreed about the effects of factors that affected the quality of education on learner performance such as poor training and development of educators. It emerged that there were positive SMT-centred factors such as promoting professional development of staff; educator-centred factors including maintaining exceptional lesson planning standards and presentation skills; learner-centred factors being geared towards school work while high parental involvement in school activities emerged as the overriding home-based factor noted to have a strong, positive impact on the provision of quality education and learner performance. It also emerged from the study that inter-alia, stakeholders viewed performance measurement and management as important and holding SMTs and educators accountable for poor school performance as an imperative measure for the provision of quality education. Recommendations for practice and for further research were made with a view to improving the management of the quality of education in schools. In light of that, a model for the management of the quality of education and learner performance was proposed.
- Full Text:
- Date Issued: 2015
- Authors: Kariyana, Israel
- Date: 2015
- Subjects: Quality education -- Schools -- South Africa Academic performance -- Learners -- South Africa -- Mthatha School management – Teaching and learning School management team (SMT)
- Language: English
- Type: Thesis , Doctoral , D Ed
- Identifier: http://hdl.handle.net/11260/1302 , vital:30800
- Description: The study sought to assess the impact on learners‘ academic performance of the management of the quality of education in South African schools. The study was conducted in ten independent and ten public schools in Mthatha. The study elicited information for quantitative data from 60 school management team (SMT) members, 200 educators and 400 learners who were randomly sampled from the participating purposively sampled schools. Qualitative data and document analysis were used to triangulate quantitative findings. Data collected was coded and analysed thematically. Quantitative data were analysed with the aid of the SPSS version 22 and qualitative data were analysed through content analysis. Quantitative data were presented through a blend of both descriptive and inferential statistics using tables and graphs. The study found that school management teams (SMTs) and educators were more aware than learners that there are national and provincial legislation mandates that guide the management of quality in education. However, stakeholders were of the view that schools did not use relevant national, provincial and school-based policies and procedures to guide the provision and management of quality in education. It also emerged that learners did not conduct themselves in a manner that promoted the provision of quality education. Participants were, nevertheless agreeable on the indicators of high-quality education. SMTs and educators held stronger views than learners about schools having clear vision and mission statements (VMS) in place but neither were displayed for all to see nor were they well known to and supported by the ii SMTs, educators and learners, thus they were not implemented. The study also established that respondents were aware of the educator-centred, SMT-centred as well as learner-centred factors that affected the quality of education and that factors that promote high-quality education were largely absent in schools. Stakeholders also agreed about the effects of factors that affected the quality of education on learner performance such as poor training and development of educators. It emerged that there were positive SMT-centred factors such as promoting professional development of staff; educator-centred factors including maintaining exceptional lesson planning standards and presentation skills; learner-centred factors being geared towards school work while high parental involvement in school activities emerged as the overriding home-based factor noted to have a strong, positive impact on the provision of quality education and learner performance. It also emerged from the study that inter-alia, stakeholders viewed performance measurement and management as important and holding SMTs and educators accountable for poor school performance as an imperative measure for the provision of quality education. Recommendations for practice and for further research were made with a view to improving the management of the quality of education in schools. In light of that, a model for the management of the quality of education and learner performance was proposed.
- Full Text:
- Date Issued: 2015
Challenges faced by Teachers in applying reading strategies when teaching English reading in the foundation phase in the Mthatha District
- Authors: Cweba, Vuyokazi
- Date: 2015
- Subjects: Reading(Foundation phase) English language -- Study and teaching -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Doctoral , D Ed
- Identifier: http://hdl.handle.net/11260/856 , vital:29938
- Description: This study sought to investigate challenges faced by teachers in applying reading strategies when teaching reading in the Foundation Phase in the Mthatha District in South Africa. The study was conducted at Four Junior Secondary Schools. It was prompted by a deep concern about challenges faced by teachers in applying reading strategies required in the Foundation Phase. While studies have been carried out on applying reading strategies in the Foundation Phase, few studies have looked at the factors impacting on reading in South African schools, especially in the Mthatha District where isiXhosa is the mother tongue. The method used in this study involved a qualitative approach. The study addressed the following research questions: What strategies are used in the Foundation Phase? What type of challenges are faced by teachers? To what extent are educators trained to teach reading in the Foundation Phase? Does the lack of resources affect the performance of learners? To what extent does the use of a second language affect the performance of Foundation Phase learners? Do teachers receive enough support from the Department of Education to teach reading? The study is a multiple-case study and data were collected through individual interviews and focus group interviews (sixteen teachers were interviewed). Content analysis guided the data analysis through themes derived from the subsidiary questions. Data reporting took the form of thick description and verbatim quotations in line with the qualitative approach of the study. A pilot study was conducted in two Junior Secondary Schools for the purpose of validity and reliability. ii The study`s findings revealed that: Different reading strategies were used by teachers in the Foundation Phase, teachers faced many challenges in applying reading strategies such as teacher training in the teaching of reading. This suggests that intervention is needed by the Department of Education such as providing relevant resources which are essential in order to address the problem of reading. Improvisation by teachers to improve reading material, insufficient allocation of time, multilingualism, teacher competence, lack of motivation and parental involvement in relation to learner performance in reading all need attention in order to solve problems. Furthermore, lack of resources hinders the reading ability of learners. The use of home language as a medium of instruction in teaching reading is highlighted. There is insufficient support by the Department of Education for Foundation Phase teachers to teach reading. Based on the study findings, the researcher has recommended that teachers should be urged to use reading strategies in a way that benefits learners. The use of reading strategies, therefore, needs more attention. Libraries should be built in these schools to enable learners to develop a culture of reading. Education development officers, subject advisors, lead teachers and parents should work together to improve the reading ability of Foundation Phase learners.
- Full Text:
- Date Issued: 2015
- Authors: Cweba, Vuyokazi
- Date: 2015
- Subjects: Reading(Foundation phase) English language -- Study and teaching -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Doctoral , D Ed
- Identifier: http://hdl.handle.net/11260/856 , vital:29938
- Description: This study sought to investigate challenges faced by teachers in applying reading strategies when teaching reading in the Foundation Phase in the Mthatha District in South Africa. The study was conducted at Four Junior Secondary Schools. It was prompted by a deep concern about challenges faced by teachers in applying reading strategies required in the Foundation Phase. While studies have been carried out on applying reading strategies in the Foundation Phase, few studies have looked at the factors impacting on reading in South African schools, especially in the Mthatha District where isiXhosa is the mother tongue. The method used in this study involved a qualitative approach. The study addressed the following research questions: What strategies are used in the Foundation Phase? What type of challenges are faced by teachers? To what extent are educators trained to teach reading in the Foundation Phase? Does the lack of resources affect the performance of learners? To what extent does the use of a second language affect the performance of Foundation Phase learners? Do teachers receive enough support from the Department of Education to teach reading? The study is a multiple-case study and data were collected through individual interviews and focus group interviews (sixteen teachers were interviewed). Content analysis guided the data analysis through themes derived from the subsidiary questions. Data reporting took the form of thick description and verbatim quotations in line with the qualitative approach of the study. A pilot study was conducted in two Junior Secondary Schools for the purpose of validity and reliability. ii The study`s findings revealed that: Different reading strategies were used by teachers in the Foundation Phase, teachers faced many challenges in applying reading strategies such as teacher training in the teaching of reading. This suggests that intervention is needed by the Department of Education such as providing relevant resources which are essential in order to address the problem of reading. Improvisation by teachers to improve reading material, insufficient allocation of time, multilingualism, teacher competence, lack of motivation and parental involvement in relation to learner performance in reading all need attention in order to solve problems. Furthermore, lack of resources hinders the reading ability of learners. The use of home language as a medium of instruction in teaching reading is highlighted. There is insufficient support by the Department of Education for Foundation Phase teachers to teach reading. Based on the study findings, the researcher has recommended that teachers should be urged to use reading strategies in a way that benefits learners. The use of reading strategies, therefore, needs more attention. Libraries should be built in these schools to enable learners to develop a culture of reading. Education development officers, subject advisors, lead teachers and parents should work together to improve the reading ability of Foundation Phase learners.
- Full Text:
- Date Issued: 2015
Comparison between Endothelin, Nitric Oxide and their Association to Blood Pressure and Body Composition in HIV Patients, in Mthatha
- Authors: Zono, Sinethemba
- Date: 2015
- Language: English
- Type: Masters theses , text
- Identifier: http://hdl.handle.net/11260/2909 , vital:43105
- Description: Background: Dysfunction of the vascular endothelium is an early finding in the progression of cardiovascular disease and is closely related to clinical events in patients with obesity and hypertension. Vascular function is mediated by nitric oxide (NO) and endothelin (ET-1) which serve as natural counterparts. The aim of the study was to determine the physiological effects of HIV infection, blood pressure and body composition on the changes of ET-1 and NO and association between ET-1 and NO. Methods and results: This was a descriptive and comparative study. A Quota sample method was used. The study population consisted of 154 participants categorized into the following groups: 57 HIV negative participants (A), 40 HIV positive not on treatment participants and 57 HIV positive on treatment participants. Enzyme immunoassay kit was used for the quantitative determination of ET-1 and Nitrate/nitrite colorimetric assay kit was used for the determination of NO. Anthropometric measurements, body composition were determined. Hemodynamic measurements were also taken into account. Results: Resting metabolism, waist circumference (WC) and hip circumference had low mean levels in both HIV positives groups compared to HIV negative group. On lipid profiles visceral fat (VF), whole fat (WF) had low mean levels but skeletal muscle fat (SMF) showed the highest mean levels in both HIV positive groups. All the blood pressures between HIV groups were on a normal range scale. Mean values of endothelin and nitric oxide are increased in HIV positive not on ART and HIV (+) on ART compared with the HIV negative group. Conclusion: NO, ET-1, ART and HIV itself were associated with the pathogenesis of endothelial dysfunction in persons with HIV infection. Elevated endothelial markers namely ET-1 and NO can lead to improvement of endothelium dependent relaxation to some extent but not completely. Although these markers have deleterious effect on the endothelium but can also serve as up-regulator of hypertension. Key words: HIV-infection, antiretroviral therapy, endothelial dysfunction, Endothelin1 (ET-1), nitric oxide (NO), blood pressures (BPs). , Thesis (MSc) -- Faculty of Health Sciences, 2015
- Full Text:
- Date Issued: 2015
- Authors: Zono, Sinethemba
- Date: 2015
- Language: English
- Type: Masters theses , text
- Identifier: http://hdl.handle.net/11260/2909 , vital:43105
- Description: Background: Dysfunction of the vascular endothelium is an early finding in the progression of cardiovascular disease and is closely related to clinical events in patients with obesity and hypertension. Vascular function is mediated by nitric oxide (NO) and endothelin (ET-1) which serve as natural counterparts. The aim of the study was to determine the physiological effects of HIV infection, blood pressure and body composition on the changes of ET-1 and NO and association between ET-1 and NO. Methods and results: This was a descriptive and comparative study. A Quota sample method was used. The study population consisted of 154 participants categorized into the following groups: 57 HIV negative participants (A), 40 HIV positive not on treatment participants and 57 HIV positive on treatment participants. Enzyme immunoassay kit was used for the quantitative determination of ET-1 and Nitrate/nitrite colorimetric assay kit was used for the determination of NO. Anthropometric measurements, body composition were determined. Hemodynamic measurements were also taken into account. Results: Resting metabolism, waist circumference (WC) and hip circumference had low mean levels in both HIV positives groups compared to HIV negative group. On lipid profiles visceral fat (VF), whole fat (WF) had low mean levels but skeletal muscle fat (SMF) showed the highest mean levels in both HIV positive groups. All the blood pressures between HIV groups were on a normal range scale. Mean values of endothelin and nitric oxide are increased in HIV positive not on ART and HIV (+) on ART compared with the HIV negative group. Conclusion: NO, ET-1, ART and HIV itself were associated with the pathogenesis of endothelial dysfunction in persons with HIV infection. Elevated endothelial markers namely ET-1 and NO can lead to improvement of endothelium dependent relaxation to some extent but not completely. Although these markers have deleterious effect on the endothelium but can also serve as up-regulator of hypertension. Key words: HIV-infection, antiretroviral therapy, endothelial dysfunction, Endothelin1 (ET-1), nitric oxide (NO), blood pressures (BPs). , Thesis (MSc) -- Faculty of Health Sciences, 2015
- Full Text:
- Date Issued: 2015
Factors contributing towards the decline in enrolment of learners in the rural Junior Secondary Schools in the Qumbu District of Education of South Africa
- Authors: Vellem, Mxolosi
- Date: 2015
- Subjects: Rural schools -- Learners -- South Africa School enrolment—Education (Junior secondary) -- South Africa -- Qumbu Rationalisation and re-alignment -- Schools
- Language: English
- Type: Thesis , M Ed
- Identifier: http://hdl.handle.net/11260/1326 , vital:30806
- Description: The purpose of this study was to investigate the factors contributing towards the decline of learners in rural junior secondary schools in the Qumbu Education District in the Eastern Cape, South Africa. This was done because in South Africa before the 1994 elections rural schools were not supported by the apartheid government. Rural areas were disadvantaged in education, in terms of finance. This resulted in poor quality of teaching and learning. Declining numbers of learners in rural schools was occurring in all rural schools. Staffs were alarmed by the declining enrolment of learners in their schools because their schools were affected. Teachers were redeployed to schools where there were sufficient learner numbers. Department of Education due to declining learner numbers in schools introduced rationalisation and re-alignment of schools, meaning closure of some schools with low learner numbers. This led to learners walking long distances to schools. This study was conducted in the Qumbu Education District. It focused on declining numbers of learner enrolment. The literature internationally focused on declining number in enrolment of learners. These learners were afraid of Physical Science (Chemistry side) as a subject. They had taken Chemistry as difficult because of the perceived link with Mathematics. Continentally the literature had alluded to teenage pregnancy, affected and infected learners with HIV/AIDS and human trafficking. In South Africa literature focused on the educational level of parents. Learners with educated parents leave rural schools to study in urban areas because of poor education which is provided in rural areas. Lack of resources in these schools could also be the cause of declining learner numbers in rural junior secondary schools. The study used a quantitative research design to elicit data from the respondents. The respondents in this study were 50 principals of the sampled rural junior secondary schools. Data was collected from 50 participants through the use of a questionnaire; 50 questionnaires were returned and the data which was finally processed was from these 50 questionnaires. The Statistical Package for Social Sciences (SPSS) was used for the analysis of the data. iii The findings of the study revealed that factors such as lack of parental involvement, socio-economic factors, HIV/AIDS - related issues, culture and gender - related issues, lack of resources, teacher and teaching - related issues and the education level of the parents were the contributing factors to the decline in enrolment of learners in rural junior secondary schools in the Qumbu Education District. In the light of the findings, the researcher recommends that more tuition time and the reduction of absenteeism by teachers can help reduce the decline of enrolment in rural junior schools in the Qumbu area. The Department must consider the number of learning areas and not teacher - pupil ratio. The Department should also introduce computer classes, woodwork, bricklaying and other practical skill subjects in these schools. Furthermore there must be resources such as laboratories, libraries and television. Some of the limitations encountered by the researcher during the study included the reluctance of the participants to take part in the research, the inaccessibility of schools in deep rural areas, the slow return rate of completed questionnaires and the obtaining of permission to undertake the study.
- Full Text:
- Date Issued: 2015
- Authors: Vellem, Mxolosi
- Date: 2015
- Subjects: Rural schools -- Learners -- South Africa School enrolment—Education (Junior secondary) -- South Africa -- Qumbu Rationalisation and re-alignment -- Schools
- Language: English
- Type: Thesis , M Ed
- Identifier: http://hdl.handle.net/11260/1326 , vital:30806
- Description: The purpose of this study was to investigate the factors contributing towards the decline of learners in rural junior secondary schools in the Qumbu Education District in the Eastern Cape, South Africa. This was done because in South Africa before the 1994 elections rural schools were not supported by the apartheid government. Rural areas were disadvantaged in education, in terms of finance. This resulted in poor quality of teaching and learning. Declining numbers of learners in rural schools was occurring in all rural schools. Staffs were alarmed by the declining enrolment of learners in their schools because their schools were affected. Teachers were redeployed to schools where there were sufficient learner numbers. Department of Education due to declining learner numbers in schools introduced rationalisation and re-alignment of schools, meaning closure of some schools with low learner numbers. This led to learners walking long distances to schools. This study was conducted in the Qumbu Education District. It focused on declining numbers of learner enrolment. The literature internationally focused on declining number in enrolment of learners. These learners were afraid of Physical Science (Chemistry side) as a subject. They had taken Chemistry as difficult because of the perceived link with Mathematics. Continentally the literature had alluded to teenage pregnancy, affected and infected learners with HIV/AIDS and human trafficking. In South Africa literature focused on the educational level of parents. Learners with educated parents leave rural schools to study in urban areas because of poor education which is provided in rural areas. Lack of resources in these schools could also be the cause of declining learner numbers in rural junior secondary schools. The study used a quantitative research design to elicit data from the respondents. The respondents in this study were 50 principals of the sampled rural junior secondary schools. Data was collected from 50 participants through the use of a questionnaire; 50 questionnaires were returned and the data which was finally processed was from these 50 questionnaires. The Statistical Package for Social Sciences (SPSS) was used for the analysis of the data. iii The findings of the study revealed that factors such as lack of parental involvement, socio-economic factors, HIV/AIDS - related issues, culture and gender - related issues, lack of resources, teacher and teaching - related issues and the education level of the parents were the contributing factors to the decline in enrolment of learners in rural junior secondary schools in the Qumbu Education District. In the light of the findings, the researcher recommends that more tuition time and the reduction of absenteeism by teachers can help reduce the decline of enrolment in rural junior schools in the Qumbu area. The Department must consider the number of learning areas and not teacher - pupil ratio. The Department should also introduce computer classes, woodwork, bricklaying and other practical skill subjects in these schools. Furthermore there must be resources such as laboratories, libraries and television. Some of the limitations encountered by the researcher during the study included the reluctance of the participants to take part in the research, the inaccessibility of schools in deep rural areas, the slow return rate of completed questionnaires and the obtaining of permission to undertake the study.
- Full Text:
- Date Issued: 2015
IMMUNE RESPONSE TO SPECIFIC MYCOBACTERIUM TUBERCULOSIS ANTIGENS AMONG PARASITE INFECTED SCHOOL CHILDREN IN MTHATHA
- Authors: NTOMBIZODUMO NXASANA
- Date: 2015
- Subjects: IMMUNE RESPONSE, MYCOBACTERIUM TUBERCULOSIS ANTIGENS
- Language: English
- Type: Masters, Msc
- Identifier: http://hdl.handle.net/11260/2369 , vital:41452
- Description: Children from low socio-economic communities in the Eastern Cape Province of South Africa and in South Africa at large are frequently infected by intestinal parasites. The parasites are diverse and complex pathogens that include multi-cellular helminths and single-celled protozoa. Because of this diversity, immunity to parasites is more difficult to sustain. Tuberculosis also, remains a problem in South Africa and worldwide. Infection with Mycobacterium tuberculosis can result either in the disease itself or, more commonly, latent infection. A variety of mechanisms that include both humoral and cell mediated immunity achieve host protection against mycobacterial pathogens. Macrophages and cell-mediated immunity are the primary defence mechanisms against mycobacteria. According to the literature, parasitic infections impair the body’s immune response to tuberculosis, but these diseases are not adequately researched in this province. The extent to which the school children of Mthatha are infected with intestinal parasites and latent tuberculosis, or even how their immune systems respond to these infections have not been investigated. Therefore, the immune response of school children, both of those infected and those not infected with parasites, to specific Mycobacterium tuberculosis antigens was evaluated. The present study used two study design methods: firstly, a descriptive cross-sectional design for the prevalence rates of intestinal parasites and, secondly, a case-control study for comparison of interferon gamma and T-helper 1 and T-helper 2 cytokines in parasite infected and non-parasite infected participants. A total of 137 school children participated in the survey and all were analyzed for parasites. Due to the high cost of the reagent kits, only 75 participants were included in the case-control study. Data collection methods: i) for the prevalence of intestinal parasites, formalin ethyl acetate sedimentation technique was used to process stool specimens, ii) for immune response to Mycobacterium tuberculosis antigens (measurement of interferon gamma for latent tuberculosis),the QuantiFeron TB Gold In-Tube assay was used, and iii) for the quantification of Th1 and Th2 cytokines, the Bio-Plex Pro assay was used. Out of 137 school children analyzed, 66.4% (91/137) were positive for parasites (ova and cysts). The most prevalent parasite was the pathogenic helminth, Ascaris lumbricoides at 21.9% (30/137), followed by Trichuris trichiura at 8.8%. The pathogenic protozoa, Giardia lamblia and Blastocystis hominis were both at 2.9% (4/137). The non-pathogenic protozoa, Entamoeba coli and Endolimax nana had high prevalence rates at 32.1% (44/137) and 29.2% (40/137) respectively. Associations between parasitic infections and sociodemographics showed a significant difference in participants whose parents had a low level of education and those who were unemployed (P = 0.004; P = 0.005 respectively). Out of 75 participants analyzed for tuberculosis, 53.3% (40/75) were positive. In conclusion, the present study demonstrates high prevalence rates of parasitic as well as latent tuberculosis infections in Mthatha. The study also showed that intestinal parasites, especially helminths, interfere with immune responses to TB by down-regulating Th1 response leading to reduced production of interferon gamma, a cytokine that mediates protection against TB.
- Full Text:
- Authors: NTOMBIZODUMO NXASANA
- Date: 2015
- Subjects: IMMUNE RESPONSE, MYCOBACTERIUM TUBERCULOSIS ANTIGENS
- Language: English
- Type: Masters, Msc
- Identifier: http://hdl.handle.net/11260/2369 , vital:41452
- Description: Children from low socio-economic communities in the Eastern Cape Province of South Africa and in South Africa at large are frequently infected by intestinal parasites. The parasites are diverse and complex pathogens that include multi-cellular helminths and single-celled protozoa. Because of this diversity, immunity to parasites is more difficult to sustain. Tuberculosis also, remains a problem in South Africa and worldwide. Infection with Mycobacterium tuberculosis can result either in the disease itself or, more commonly, latent infection. A variety of mechanisms that include both humoral and cell mediated immunity achieve host protection against mycobacterial pathogens. Macrophages and cell-mediated immunity are the primary defence mechanisms against mycobacteria. According to the literature, parasitic infections impair the body’s immune response to tuberculosis, but these diseases are not adequately researched in this province. The extent to which the school children of Mthatha are infected with intestinal parasites and latent tuberculosis, or even how their immune systems respond to these infections have not been investigated. Therefore, the immune response of school children, both of those infected and those not infected with parasites, to specific Mycobacterium tuberculosis antigens was evaluated. The present study used two study design methods: firstly, a descriptive cross-sectional design for the prevalence rates of intestinal parasites and, secondly, a case-control study for comparison of interferon gamma and T-helper 1 and T-helper 2 cytokines in parasite infected and non-parasite infected participants. A total of 137 school children participated in the survey and all were analyzed for parasites. Due to the high cost of the reagent kits, only 75 participants were included in the case-control study. Data collection methods: i) for the prevalence of intestinal parasites, formalin ethyl acetate sedimentation technique was used to process stool specimens, ii) for immune response to Mycobacterium tuberculosis antigens (measurement of interferon gamma for latent tuberculosis),the QuantiFeron TB Gold In-Tube assay was used, and iii) for the quantification of Th1 and Th2 cytokines, the Bio-Plex Pro assay was used. Out of 137 school children analyzed, 66.4% (91/137) were positive for parasites (ova and cysts). The most prevalent parasite was the pathogenic helminth, Ascaris lumbricoides at 21.9% (30/137), followed by Trichuris trichiura at 8.8%. The pathogenic protozoa, Giardia lamblia and Blastocystis hominis were both at 2.9% (4/137). The non-pathogenic protozoa, Entamoeba coli and Endolimax nana had high prevalence rates at 32.1% (44/137) and 29.2% (40/137) respectively. Associations between parasitic infections and sociodemographics showed a significant difference in participants whose parents had a low level of education and those who were unemployed (P = 0.004; P = 0.005 respectively). Out of 75 participants analyzed for tuberculosis, 53.3% (40/75) were positive. In conclusion, the present study demonstrates high prevalence rates of parasitic as well as latent tuberculosis infections in Mthatha. The study also showed that intestinal parasites, especially helminths, interfere with immune responses to TB by down-regulating Th1 response leading to reduced production of interferon gamma, a cytokine that mediates protection against TB.
- Full Text:
Investigation into School Managers’ role as facilitators of Teachers to improve Teacher effectiveness and efficiency
- Authors: Peter, Tembelihle
- Date: 2015
- Subjects: School principals -- Facilitation -- South Africa Teachers – Effectiveness and efficiency School manager -- Educators—Professional development-- South Africa – Eastern Cape
- Language: English
- Type: Thesis , Masters , M Ed
- Identifier: http://hdl.handle.net/11260/1314 , vital:30803
- Description: This research study examined the role of management by school managers in the three strata schools of the Mthatha Education District in the Province of the Eastern Cape of South Africa. The researcher tried to show how School managers provide a leadership role especially in the Mthatha schools in the Eastern Cape Province of South Africa. It was deduced from the statistical data presented that there is a significant correlation between a school manager’s tasks and the quality of education. This shows that when school managers plan properly, organizing properly, leading and control management task be better all resources of the school will be managed better. The proper execution of management tasks of planning, organizing, leading and control by school managers have contributed extensively to the success of schools. The researcher used both qualitative and quantitative methods in –order to collect data. Two instruments namely, questionnaires and interviews were used in –order to collect data. Tools used during quantitative research design data collection are questionnaires. Questionnaires were used in order to pilot the study for the purposes of identifying with rich information. The researcher used structured questions for quantitative questionnaires. Respondents answered questionnaires in the absence of the researcher in-order to allow anonymity and a stress –free environment. Tools used for the qualitative research design data collection method were interviews. Interviews were used for the information rich subjects. During interviews, the researcher used face-to-face, one- to- one interviews with each subject. The sample subjects in this study for the quantitative method were school managers of Mthatha schools. The total number of participants was 14. All of them returned their questionnaire responses at the agreed time with the researcher. Amongst the findings that emerged were; a high level of enthusiasm in all three schools for change; however, different kinds of hindrances were experienced. ii Finally, recommendations and suggestions were made starting that schools have to follow strict management /leadership programs.
- Full Text:
- Date Issued: 2015
- Authors: Peter, Tembelihle
- Date: 2015
- Subjects: School principals -- Facilitation -- South Africa Teachers – Effectiveness and efficiency School manager -- Educators—Professional development-- South Africa – Eastern Cape
- Language: English
- Type: Thesis , Masters , M Ed
- Identifier: http://hdl.handle.net/11260/1314 , vital:30803
- Description: This research study examined the role of management by school managers in the three strata schools of the Mthatha Education District in the Province of the Eastern Cape of South Africa. The researcher tried to show how School managers provide a leadership role especially in the Mthatha schools in the Eastern Cape Province of South Africa. It was deduced from the statistical data presented that there is a significant correlation between a school manager’s tasks and the quality of education. This shows that when school managers plan properly, organizing properly, leading and control management task be better all resources of the school will be managed better. The proper execution of management tasks of planning, organizing, leading and control by school managers have contributed extensively to the success of schools. The researcher used both qualitative and quantitative methods in –order to collect data. Two instruments namely, questionnaires and interviews were used in –order to collect data. Tools used during quantitative research design data collection are questionnaires. Questionnaires were used in order to pilot the study for the purposes of identifying with rich information. The researcher used structured questions for quantitative questionnaires. Respondents answered questionnaires in the absence of the researcher in-order to allow anonymity and a stress –free environment. Tools used for the qualitative research design data collection method were interviews. Interviews were used for the information rich subjects. During interviews, the researcher used face-to-face, one- to- one interviews with each subject. The sample subjects in this study for the quantitative method were school managers of Mthatha schools. The total number of participants was 14. All of them returned their questionnaire responses at the agreed time with the researcher. Amongst the findings that emerged were; a high level of enthusiasm in all three schools for change; however, different kinds of hindrances were experienced. ii Finally, recommendations and suggestions were made starting that schools have to follow strict management /leadership programs.
- Full Text:
- Date Issued: 2015
Learners' Attitudes Influencing their performance in the study of Mathematics in Seven Selected Senior Secondary Schools in the Mthatha Education District
- Authors: Gyeke, Yirenkyi - Darko
- Date: 2015
- Subjects: Mathematics Education
- Language: English
- Type: Thesis, D Ed
- Identifier: http://hdl.handle.net/11260/2222 , vital:40919
- Full Text: false
- Authors: Gyeke, Yirenkyi - Darko
- Date: 2015
- Subjects: Mathematics Education
- Language: English
- Type: Thesis, D Ed
- Identifier: http://hdl.handle.net/11260/2222 , vital:40919
- Full Text: false
Perceptions of Junior Secondary School Educators on the Effects of Overcrowding in Classrooms on Learner Performance in Maluti District, Eastern Cape Province
- Authors: Mbangeni, Monwabisi Gidwell
- Date: 2015
- Subjects: Classrooms overcrowding -- Schools Teachers -- Learners -- Education Learner performance -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , M Ed
- Identifier: http://hdl.handle.net/11260/923 , vital:30051
- Description: The study investigated overcrowding classrooms and its impact on learners and teachers’ performance, efficiency and effectiveness. This action was prompted by the researcher’s observation of learners’ poor performance and teachers’ loss of instructional time in overcrowded classrooms. Literature was reviewed to place the study in gap lapse prospective which this study was to fill. Quantitative research method was used to be able to collect the most applicable data that would be able to produce valid and reliable information for the compilation of the research report. Revelations from the collected data were that overcrowded classrooms have adverse effects on both the teacher and learner performance and activities in schools where overcrowding is evident. Based on the revelations the research made some recommendations to contribute towards finding solution to the problem investigated in this study. The conclusion that could be drawn was that there is need for the Department of Education (DoE) to conduct elaborate study in schools where overcrowding exists and make a concerted effort to provide adequate classrooms to be able to help learners and teachers benefit from the provision of education being delivered.
- Full Text:
- Date Issued: 2015
- Authors: Mbangeni, Monwabisi Gidwell
- Date: 2015
- Subjects: Classrooms overcrowding -- Schools Teachers -- Learners -- Education Learner performance -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , M Ed
- Identifier: http://hdl.handle.net/11260/923 , vital:30051
- Description: The study investigated overcrowding classrooms and its impact on learners and teachers’ performance, efficiency and effectiveness. This action was prompted by the researcher’s observation of learners’ poor performance and teachers’ loss of instructional time in overcrowded classrooms. Literature was reviewed to place the study in gap lapse prospective which this study was to fill. Quantitative research method was used to be able to collect the most applicable data that would be able to produce valid and reliable information for the compilation of the research report. Revelations from the collected data were that overcrowded classrooms have adverse effects on both the teacher and learner performance and activities in schools where overcrowding is evident. Based on the revelations the research made some recommendations to contribute towards finding solution to the problem investigated in this study. The conclusion that could be drawn was that there is need for the Department of Education (DoE) to conduct elaborate study in schools where overcrowding exists and make a concerted effort to provide adequate classrooms to be able to help learners and teachers benefit from the provision of education being delivered.
- Full Text:
- Date Issued: 2015
Perspectives on the effects of Teenage pregnancy on Learning and teaching in Junior Secondary Schools of the Butterworth Education District
- Authors: Lubambo, Mzikayise Wiseman
- Date: 2015
- Subjects: Teenage pregnancy , Education (Primary schools)
- Language: English
- Type: Thesis , Masters , M Ed
- Identifier: http://hdl.handle.net/11260/867 , vital:29939
- Description: The study is about the effects of teenage pregnancy on learning and teaching in Junior and Senior Secondary Schools of Butterworth District. The researcher’s objective of the study was to determine how pregnancy affects the learner’s performance on learning and teaching in schools. Qualitative paradigm informed the study. The participants were drawn from teenagers; teachers and parents areall from rural schools, around Butterworth Education District through the use of non-probability, purposive and convenient samples. The sample included learners from ages 13-19 who were pregnant and those who were once pregnant while in schools, teachers who taught pregnant learners in their schools and parents who were having pregnant children at schools. A total of fifteen (15) participants were involved in the interview. The data collected was analyzed and interpreted during data collection and thereafter. The findings of the study showed that absenteeism, drop-out, poor academic performance, poverty and unemployment which are the results of pregnancy are some of the contributory factors that affect learning and teaching in schools. Recommendations were made based on the findings of the study. The study concludes by recommending awareness campaign on learner pregnancy.
- Full Text:
- Date Issued: 2015
- Authors: Lubambo, Mzikayise Wiseman
- Date: 2015
- Subjects: Teenage pregnancy , Education (Primary schools)
- Language: English
- Type: Thesis , Masters , M Ed
- Identifier: http://hdl.handle.net/11260/867 , vital:29939
- Description: The study is about the effects of teenage pregnancy on learning and teaching in Junior and Senior Secondary Schools of Butterworth District. The researcher’s objective of the study was to determine how pregnancy affects the learner’s performance on learning and teaching in schools. Qualitative paradigm informed the study. The participants were drawn from teenagers; teachers and parents areall from rural schools, around Butterworth Education District through the use of non-probability, purposive and convenient samples. The sample included learners from ages 13-19 who were pregnant and those who were once pregnant while in schools, teachers who taught pregnant learners in their schools and parents who were having pregnant children at schools. A total of fifteen (15) participants were involved in the interview. The data collected was analyzed and interpreted during data collection and thereafter. The findings of the study showed that absenteeism, drop-out, poor academic performance, poverty and unemployment which are the results of pregnancy are some of the contributory factors that affect learning and teaching in schools. Recommendations were made based on the findings of the study. The study concludes by recommending awareness campaign on learner pregnancy.
- Full Text:
- Date Issued: 2015
The evaluation of continuous quality improvement amongst the Community Health Centers of Lukhanji sub-district, of Chris Hani District Municipality, Eastern Cape
- Authors: Qotoyi, Ntombesitatu
- Date: 2015
- Subjects: Health Standard Compliance Health Care -- Quality improvement Community health centrers -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters/Doctoral , MSc Nursing
- Identifier: http://hdl.handle.net/11260/1465 , vital:35973
- Description: Continuous Quality Improvement is a system that seeks to improve the provision of services with an emphasis on future results (Tomey, 2009). It is a process that involves evaluation, actions and mindset to strive constantly for excellence (Sullivan, 2012). Evaluation of quality in health care has evolved into a dynamic and modern science which plays a significant role in patient safety, quality assurance (QA), benchmarking and continuous quality improvement (CQI). Improved quality has a positive impact on patient and staff satisfaction, improving the efficiency and effectiveness of healthcare provision in both the public and private sector, eventually leading to increased trust in the health system (Whittaker, Burns, Doyle and Fenney, 1998). The purpose of this study was to explore and describe the factors that influence continuous quality improvement amongst the Community Health Centers of Lukhanji sub district, of Chris Hani District Municipality, Eastern Cape. The standards of the community health centers were assessed against the National Core Standards of the South African National Department of Health. Donabedian‟s tripartite model (1988) which addresses three elements of quality assessment, namely structure, process and outcome, led this study. A quantitative, descriptive design was adapted, using National Core Standard checklists and assessment questionnaires to collect data from two community health centers. Respondents were sampled through simple random sample. Data were collected through staff and patient interviews, document reviews, patient record assessment and observations. The raw data were transferred to the District Health Information System (DHIS) Assessment Questionnaire CHC/CDC programme which generated the results into colour coded tables (dashboard view). According to DHIS software version: 1.4.1.12 data base version: 19 June 2013 each community health center is listed in the DHIS programme for each district to capture data. The researcher consolidated and interpreted the results according to the expected level of performance and compliance as per the South African Office of the Health Standard Compliance. The results highlighted a need for improvement in the six priority areas for the Community Health Centers (CHCs) to reach the acceptable performance of 80% and above. CHC A scored 85% in availability of medicines and supplies however CHC B obtained 68 %. For cleanliness both CHCs obtained 54% which need more than 20% effort to reach the acceptable performance of 80%. In patient safety CHC A obtained 48% whilst CHC B had a score of 36%. For infection prevention and control CHC A scored 61% and CHC B obtained 53%. In the assessment of positive and caring attitudes CHC A had a score of 77% whereas CHC B obtained 40% indicative of noncompliance. In waiting time measures CHC A was compliant with a score of 82% however CHC B had a score of 71%. The results of this study indicated that there is a need for the CHCs to put systems in place to strengthen PHC effectiveness and ensure patient safety. The results and recommendations would assist in service delivery and continuous quality improvement in the community health centers.
- Full Text:
- Date Issued: 2015
- Authors: Qotoyi, Ntombesitatu
- Date: 2015
- Subjects: Health Standard Compliance Health Care -- Quality improvement Community health centrers -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters/Doctoral , MSc Nursing
- Identifier: http://hdl.handle.net/11260/1465 , vital:35973
- Description: Continuous Quality Improvement is a system that seeks to improve the provision of services with an emphasis on future results (Tomey, 2009). It is a process that involves evaluation, actions and mindset to strive constantly for excellence (Sullivan, 2012). Evaluation of quality in health care has evolved into a dynamic and modern science which plays a significant role in patient safety, quality assurance (QA), benchmarking and continuous quality improvement (CQI). Improved quality has a positive impact on patient and staff satisfaction, improving the efficiency and effectiveness of healthcare provision in both the public and private sector, eventually leading to increased trust in the health system (Whittaker, Burns, Doyle and Fenney, 1998). The purpose of this study was to explore and describe the factors that influence continuous quality improvement amongst the Community Health Centers of Lukhanji sub district, of Chris Hani District Municipality, Eastern Cape. The standards of the community health centers were assessed against the National Core Standards of the South African National Department of Health. Donabedian‟s tripartite model (1988) which addresses three elements of quality assessment, namely structure, process and outcome, led this study. A quantitative, descriptive design was adapted, using National Core Standard checklists and assessment questionnaires to collect data from two community health centers. Respondents were sampled through simple random sample. Data were collected through staff and patient interviews, document reviews, patient record assessment and observations. The raw data were transferred to the District Health Information System (DHIS) Assessment Questionnaire CHC/CDC programme which generated the results into colour coded tables (dashboard view). According to DHIS software version: 1.4.1.12 data base version: 19 June 2013 each community health center is listed in the DHIS programme for each district to capture data. The researcher consolidated and interpreted the results according to the expected level of performance and compliance as per the South African Office of the Health Standard Compliance. The results highlighted a need for improvement in the six priority areas for the Community Health Centers (CHCs) to reach the acceptable performance of 80% and above. CHC A scored 85% in availability of medicines and supplies however CHC B obtained 68 %. For cleanliness both CHCs obtained 54% which need more than 20% effort to reach the acceptable performance of 80%. In patient safety CHC A obtained 48% whilst CHC B had a score of 36%. For infection prevention and control CHC A scored 61% and CHC B obtained 53%. In the assessment of positive and caring attitudes CHC A had a score of 77% whereas CHC B obtained 40% indicative of noncompliance. In waiting time measures CHC A was compliant with a score of 82% however CHC B had a score of 71%. The results of this study indicated that there is a need for the CHCs to put systems in place to strengthen PHC effectiveness and ensure patient safety. The results and recommendations would assist in service delivery and continuous quality improvement in the community health centers.
- Full Text:
- Date Issued: 2015
The integration of previously hospital based Antiretroviral sites into Primary Health Care clinics in Lukhanji sub district of Chris Hani District Municipality
- Authors: Pakade, Nonkoliso
- Date: 2015
- Subjects: HIV/AIDS -- Antiretroviral(ARV) -- Eastern Cape -- South Africa Human Immune Virus(HIV) -- Antiretroviral therapy(ART) treatment
- Language: English
- Type: Thesis , Masters/Doctoral , MSc Nursing
- Identifier: http://hdl.handle.net/11260/1431 , vital:35585
- Description: The first country to take note of HIV/AIDS was United States of America in the report published by Atlanta based Centers for Disease Control (CDC) and Prevention (Barnett and Whiteside, 2006). In the past years ARV program was largely hospital-based where clients were assessed by doctors, discussed with multidisciplinary team which involved social workers, dieticians and pharmacists before initiated on treatment. The integration of ARV services into PHC was one of the strategies proposed to increase access to treatment for people living with HIV/AIDS (WHO, 2010). The study sought to describe the integration of previously hospital based ARV sites into PHC clinics in Lukhanji sub-district of Chris Hani Health District in Eastern Cape. A qualitative research design was followed and a phenomenological approach was used to examine the experiences of clients who previously took ARV treatment at Frontier hospital and were transferred to take treatment at Ezibeleni, Ilinge, Philani and Sada clinics. An interview guide was used for data collection. Participants were sampled through purposive sampling. The study was composed of four focus groups for clients with a total of forty (18 males and 22 females) and 10 professional nurses for semi structured individual interviews. In the analysis of data, the collected data from voice recordings were transcribed verbatim and translated from isiXhosa to English. The researcher immersed herself into the data, re read, and themes and sub-themes emerged. Related topics to each other were grouped together in order to reduce the number of categories and to create themes. The similar categories were grouped and analyzed. Findings indicated that integration of ART sites into PHC clinics was a strategy put in place to increase accessibility and availability of ARV treatment to all communities. Both participants stated that integration brought services nearer to people and caused much relief from spending more money for travelling long distances. Ambulance delays were reported by both participants as the major challenge in the referral system between clinics and the hospital. Other challenges facing integration of ART services into PHC clinics included long waiting times caused by shortage of staff in the clinics, lack of consulting rooms for nurses and waiting areas for clients. Also lack of other health care professionals including social workers, dieticians, and psychologists was mentioned. The recommendations made by the researcher on the conclusion of this study addressed all the challenges mentioned by participants. The aim was to increase accessibility and availability of ART services to all the communities.
- Full Text:
- Date Issued: 2015
- Authors: Pakade, Nonkoliso
- Date: 2015
- Subjects: HIV/AIDS -- Antiretroviral(ARV) -- Eastern Cape -- South Africa Human Immune Virus(HIV) -- Antiretroviral therapy(ART) treatment
- Language: English
- Type: Thesis , Masters/Doctoral , MSc Nursing
- Identifier: http://hdl.handle.net/11260/1431 , vital:35585
- Description: The first country to take note of HIV/AIDS was United States of America in the report published by Atlanta based Centers for Disease Control (CDC) and Prevention (Barnett and Whiteside, 2006). In the past years ARV program was largely hospital-based where clients were assessed by doctors, discussed with multidisciplinary team which involved social workers, dieticians and pharmacists before initiated on treatment. The integration of ARV services into PHC was one of the strategies proposed to increase access to treatment for people living with HIV/AIDS (WHO, 2010). The study sought to describe the integration of previously hospital based ARV sites into PHC clinics in Lukhanji sub-district of Chris Hani Health District in Eastern Cape. A qualitative research design was followed and a phenomenological approach was used to examine the experiences of clients who previously took ARV treatment at Frontier hospital and were transferred to take treatment at Ezibeleni, Ilinge, Philani and Sada clinics. An interview guide was used for data collection. Participants were sampled through purposive sampling. The study was composed of four focus groups for clients with a total of forty (18 males and 22 females) and 10 professional nurses for semi structured individual interviews. In the analysis of data, the collected data from voice recordings were transcribed verbatim and translated from isiXhosa to English. The researcher immersed herself into the data, re read, and themes and sub-themes emerged. Related topics to each other were grouped together in order to reduce the number of categories and to create themes. The similar categories were grouped and analyzed. Findings indicated that integration of ART sites into PHC clinics was a strategy put in place to increase accessibility and availability of ARV treatment to all communities. Both participants stated that integration brought services nearer to people and caused much relief from spending more money for travelling long distances. Ambulance delays were reported by both participants as the major challenge in the referral system between clinics and the hospital. Other challenges facing integration of ART services into PHC clinics included long waiting times caused by shortage of staff in the clinics, lack of consulting rooms for nurses and waiting areas for clients. Also lack of other health care professionals including social workers, dieticians, and psychologists was mentioned. The recommendations made by the researcher on the conclusion of this study addressed all the challenges mentioned by participants. The aim was to increase accessibility and availability of ART services to all the communities.
- Full Text:
- Date Issued: 2015
The Role of Biomarkers in the Management of Stroke in Eastern Cape Province
- Authors: Collin Asongapha Forka
- Date: 2015
- Language: English
- Type: Masters
- Identifier: http://hdl.handle.net/11260/2846 , vital:42964
- Description: ABSTRACT Stroke is defined as rapidly developed clinical signs of focal (or global) disturbance of the cerebral function, lasting more than 24 hours with no apparent cause other than a vascular origin. A biomarker is defined as “a physiological characteristic that can be objectively measured and evaluated as an indicator of normal biological or pathogenic process as well as pharmacological responses to a therapeutic interventions. The aim of this study was to investigate the role of biomarkers in defining inflammation, endogenous oxidants/antioxidant status (oxidative stress imbalance) and traditional cardiovascular risk factors. This case (stroke types and subtypes) – control (healthy) study (matched for gender and age) was conducted between December 2012 and June 2015. Mthatha Hospital complex served as the study setting. Nelson Mandela Academic Hospital (NMAH) is a tertiary facility that provides health care to South African population, majority of whom dwell in rural areas around the hospital. Student t-test and ANOVA served to compare means between 2 groups and across >3 groups. Chi – square test was used to compare proportions between 2 groups. Multivariate (multiple linear regression, binary logistic regression, and discriminant functions) analyses were used to identify the most important risk factors of all strokes and fibrinogen to discriminate stroke types and subtypes. ROC method obtained specific ethnic cut–off points of biomarkers that associated independently with all strokes. In total 67 participants were examined: 37 cases of strokes (11 ischemic, 26 haemorrhagic, 11 lacunar ischemic, 13 intra-cerebral hematomas and 8 haemorrhagic brain ischaemia) versus 28 controls. Low socio – economic status (OR=10.3 95%CI 3.3- 32.9 p<0.0001), physical inactivity (OR=13 95% CI 3.3-51.6 p<0.0001), rural residence(OR=6.5 95% CI 1.6-26.5 p=0.004), RDW(OR=3.7 95% CI 1.3-10.9 p=0.016), D – dimer (OR=17.4 95% CI 2.9-104 p=0.002), Fibrinogen (OR=35.1 95% CI 3.5-356.5 p=0.003), and BMI(OR=1.387 95% CI 0.985-2 p=0.06) were the most independent risk factors of all strokes. RDW, Platelets, D-dimer, and Neutrophils were the most discriminant of absence of strokes, ischaemic and haemorrhagic types of stroke. Only Fibrinogen and BNP were the most discriminant of stroke subtypes in low socio–economic status. Meanwhile, Platelets, Neutrophils, and CRP were the most discriminant of stroke subtypes in high socio – economic status. The cut-off points of RDW>14%, Fibrinogen>3.5 g/L, and D-dimer>0.5g/mL separated efficiently all stroke types and controls. Independent variations (R2 = 48%) of Fibrinogen in all participants were explained by increase in CRP (Beta = 0.315; P = 0.003), Platelets (Beta = 0.280; P = 0.004), BMI (Beta = 0.268; P = 0.006), and Monocytes (Beta = 0.241; P = 0.014).iii In conclusion, increased levels of Biomarkers of inflammation, thrombosis, hypercoagulability, but opposite variations of innate immunity (increase in monocytes, decrease or increase in neutrophils), overweight/Obesity, low socio-economic status, physical inactivity, and rural residence were the major risk factors of all strokes. Biomarkers of inflammation have superior performance to diagnose all strokes and to discriminate stroke types and to predict the severity of stroke subtypes than the few traditional cardiovascular risk factors. Education, adequate diet, exercise, reduction of poverty, other measures of secondary prevention, applied research, and integration of chemical pathology in the management of strokes are needed in personalised medicine with cheap tools (RDW, platelets and Fibrinogen) in absence of neuro – imaging in the poorest Eastern Cape province of South Africa.
- Full Text:
- Authors: Collin Asongapha Forka
- Date: 2015
- Language: English
- Type: Masters
- Identifier: http://hdl.handle.net/11260/2846 , vital:42964
- Description: ABSTRACT Stroke is defined as rapidly developed clinical signs of focal (or global) disturbance of the cerebral function, lasting more than 24 hours with no apparent cause other than a vascular origin. A biomarker is defined as “a physiological characteristic that can be objectively measured and evaluated as an indicator of normal biological or pathogenic process as well as pharmacological responses to a therapeutic interventions. The aim of this study was to investigate the role of biomarkers in defining inflammation, endogenous oxidants/antioxidant status (oxidative stress imbalance) and traditional cardiovascular risk factors. This case (stroke types and subtypes) – control (healthy) study (matched for gender and age) was conducted between December 2012 and June 2015. Mthatha Hospital complex served as the study setting. Nelson Mandela Academic Hospital (NMAH) is a tertiary facility that provides health care to South African population, majority of whom dwell in rural areas around the hospital. Student t-test and ANOVA served to compare means between 2 groups and across >3 groups. Chi – square test was used to compare proportions between 2 groups. Multivariate (multiple linear regression, binary logistic regression, and discriminant functions) analyses were used to identify the most important risk factors of all strokes and fibrinogen to discriminate stroke types and subtypes. ROC method obtained specific ethnic cut–off points of biomarkers that associated independently with all strokes. In total 67 participants were examined: 37 cases of strokes (11 ischemic, 26 haemorrhagic, 11 lacunar ischemic, 13 intra-cerebral hematomas and 8 haemorrhagic brain ischaemia) versus 28 controls. Low socio – economic status (OR=10.3 95%CI 3.3- 32.9 p<0.0001), physical inactivity (OR=13 95% CI 3.3-51.6 p<0.0001), rural residence(OR=6.5 95% CI 1.6-26.5 p=0.004), RDW(OR=3.7 95% CI 1.3-10.9 p=0.016), D – dimer (OR=17.4 95% CI 2.9-104 p=0.002), Fibrinogen (OR=35.1 95% CI 3.5-356.5 p=0.003), and BMI(OR=1.387 95% CI 0.985-2 p=0.06) were the most independent risk factors of all strokes. RDW, Platelets, D-dimer, and Neutrophils were the most discriminant of absence of strokes, ischaemic and haemorrhagic types of stroke. Only Fibrinogen and BNP were the most discriminant of stroke subtypes in low socio–economic status. Meanwhile, Platelets, Neutrophils, and CRP were the most discriminant of stroke subtypes in high socio – economic status. The cut-off points of RDW>14%, Fibrinogen>3.5 g/L, and D-dimer>0.5g/mL separated efficiently all stroke types and controls. Independent variations (R2 = 48%) of Fibrinogen in all participants were explained by increase in CRP (Beta = 0.315; P = 0.003), Platelets (Beta = 0.280; P = 0.004), BMI (Beta = 0.268; P = 0.006), and Monocytes (Beta = 0.241; P = 0.014).iii In conclusion, increased levels of Biomarkers of inflammation, thrombosis, hypercoagulability, but opposite variations of innate immunity (increase in monocytes, decrease or increase in neutrophils), overweight/Obesity, low socio-economic status, physical inactivity, and rural residence were the major risk factors of all strokes. Biomarkers of inflammation have superior performance to diagnose all strokes and to discriminate stroke types and to predict the severity of stroke subtypes than the few traditional cardiovascular risk factors. Education, adequate diet, exercise, reduction of poverty, other measures of secondary prevention, applied research, and integration of chemical pathology in the management of strokes are needed in personalised medicine with cheap tools (RDW, platelets and Fibrinogen) in absence of neuro – imaging in the poorest Eastern Cape province of South Africa.
- Full Text:
The role of Teacher Unions in the governance of schools in Mthatha District of the Eastern Cape Province of South Africa
- Authors: Viti, Anderson Madodomzi
- Date: 2015
- Subjects: Teachers Unions -- School Governance Labour Unions -- School management -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , M Ed
- Identifier: http://hdl.handle.net/11260/1278 , vital:30789
- Description: The study sought to investigate the role of teacher unions in the implementation of policies in the Department Of Education in Mthatha District. The study developed out of complaints and a lot of noise that has been done by the public towards the department of education complaining about lack of commitment and necessary enforcement of policies. This has been noticed after 1994 when teacher unions became more vocal and played a noticeable role in the education system. Many teachers became members of teacher unions and the department of education has to involve teacher unions in the decisions that it has to take. Teachers began to have rights to an extent that when they feel like striking they began to have a right to do so. Schools now began to be in totally governed by SGBs. Teachers and particularly the principals and their SMTs no longer have power to enforce any of the policies to teachers and as well as to learners. It was for that reason that the researcher became interested in conducting a study on the role played by teacher unions in the implementation of policies by the DOE in Mthatha District. In the study both qualitative and quantitative research methodology has been used. Questioners have been used to collect data. In the process of collecting data 5 schools within Mthatha district were selected. All these schools were on the Mqanduli part of Mthatha District because by the time the sturdy was started researcher was working as a principal in Mqanduli. Among schools that were selected there were 2 senior secondary schools and 3 junior secondary schools. From each school a sample of 5 educators was purposely ii selected according to their duties in running g the school i.e. in each school there has to be one or two members of the SMT. The position of the person in the SMT was not considered as long as the person is serving in the SMT. Also it was considered that people who are selected are members of a teacher union regardless of which teacher union. Some of the main findings of the study were: teacher unions are confusing the SMTs in that they sometimes get confused in knowing who to listen to between the department of education and the teacher unions. Teacher unions are sometimes helpful in that they train their members in understanding the professionalism that is required at work. Sometimes teacher unions have a tendency of protecting their members even if they act irresponsible. Among many recommendations that the researcher has done he has recommended that there must be constant meetings between all stakeholders in the education system to avoid unnecessary clashes. All parties concerned about the education system must respect the learner and as such he must be always at the centre of the education system. Also those SGB members who are expected to develop policies for their schools must be trained.
- Full Text:
- Date Issued: 2015
- Authors: Viti, Anderson Madodomzi
- Date: 2015
- Subjects: Teachers Unions -- School Governance Labour Unions -- School management -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , M Ed
- Identifier: http://hdl.handle.net/11260/1278 , vital:30789
- Description: The study sought to investigate the role of teacher unions in the implementation of policies in the Department Of Education in Mthatha District. The study developed out of complaints and a lot of noise that has been done by the public towards the department of education complaining about lack of commitment and necessary enforcement of policies. This has been noticed after 1994 when teacher unions became more vocal and played a noticeable role in the education system. Many teachers became members of teacher unions and the department of education has to involve teacher unions in the decisions that it has to take. Teachers began to have rights to an extent that when they feel like striking they began to have a right to do so. Schools now began to be in totally governed by SGBs. Teachers and particularly the principals and their SMTs no longer have power to enforce any of the policies to teachers and as well as to learners. It was for that reason that the researcher became interested in conducting a study on the role played by teacher unions in the implementation of policies by the DOE in Mthatha District. In the study both qualitative and quantitative research methodology has been used. Questioners have been used to collect data. In the process of collecting data 5 schools within Mthatha district were selected. All these schools were on the Mqanduli part of Mthatha District because by the time the sturdy was started researcher was working as a principal in Mqanduli. Among schools that were selected there were 2 senior secondary schools and 3 junior secondary schools. From each school a sample of 5 educators was purposely ii selected according to their duties in running g the school i.e. in each school there has to be one or two members of the SMT. The position of the person in the SMT was not considered as long as the person is serving in the SMT. Also it was considered that people who are selected are members of a teacher union regardless of which teacher union. Some of the main findings of the study were: teacher unions are confusing the SMTs in that they sometimes get confused in knowing who to listen to between the department of education and the teacher unions. Teacher unions are sometimes helpful in that they train their members in understanding the professionalism that is required at work. Sometimes teacher unions have a tendency of protecting their members even if they act irresponsible. Among many recommendations that the researcher has done he has recommended that there must be constant meetings between all stakeholders in the education system to avoid unnecessary clashes. All parties concerned about the education system must respect the learner and as such he must be always at the centre of the education system. Also those SGB members who are expected to develop policies for their schools must be trained.
- Full Text:
- Date Issued: 2015
Working Towards Improved Facilitation of Research Capacity Development at Walter Sisulu University (WSU) Using Action Research (AR) Methodology
- Sotshangane, Nkosinathi Owen
- Authors: Sotshangane, Nkosinathi Owen
- Date: 2015
- Subjects: Capacity development -- Research Research -- Higher education Research development -- Study and teaching -- South Africa Education, higher -- Action Research -- South Africa
- Language: English
- Type: Thesis , Doctoral , D Ed
- Identifier: http://hdl.handle.net/11260/901 , vital:30009
- Description: This study was originally undertaken to change and improve the way I do my practice at Walter Sisulu University as a Research Associate whose responsibility is to facilitate research capacity development and research excellence within the University, amongst academics and postgraduate students. The success of the Research Resource Centre that I manage depends on the way I promote research culture and research productivity amongst academics and postgraduate students. According to Leedy and Ormrod (2013, p. 2), research is a systematic process that is used to collect, analyse, and interpret data in order to increase my understanding of the phenomenon about interest and concern about a given/identified phenomenon. In this case my own practice changed and improved for the better. The main objective of this study, therefore, was to examine the reasons behind the decline in research productivity in terms of research output and how this could be reversed through action research study intervention in order to enhance research productivity at Walter Sisulu University (WSU). The Department of Higher Education and Training’s (DHET) allocation of research output units for WSU indicated that there was a decline in research output from 2005 to 2010. The extent to which my practice improvement could contribute towards changing or improving research productivity was a question which this study addressed through a quantitative, qualitative and self-reflective action research cyclic inquiry. I organized sample strategies of this study as follows: For quantitative data, I used 120 lecturers as my respondents through questionnaires (females = 47 and males = 73) who were randomly selected; For qualitative data, I used 24 lecturers as respondents who were randomly selected with whom I conducted interviews; and For self-reflective action research cyclic inquiry I used 7 Transformative Education/al Studies (TES) project group members as my focus group. My research findings concluded that the heavy teaching workload at WSU was problematic and lecturers/academics could not devote time to do research. My recommendation is that research should be made compulsory so that academics become aware that at least one or two published articles are required from them, for the benefit of annual university research productivity. Some research participants also recommended that the Research Resource Centre must include programs that focus directly on active participation in research in order to increase the capacity of individual researchers so as to build a critical mass of competent researchers, perhaps by even including incentives as a reward for doing research. According to Koshy (2010), action research is a specific method of conducting research by professionals and practitioners with the ultimate aim of improving practice. My new knowledge, therefore, in respect of how a concerned Research Associate, from a Historically Disadvantaged Institution (HDI), provided the impetus to create a collaborative practice in a higher education institution which was forced to merge with two former technikons (which lacked understanding of what a university means by research productivity and research output). I consequently developed the Nkosinathi Sotshangane’s cyclic practice improvement model through self-reflective action research, from which I believed other research practitioners could learn by doing something similar in their own context.
- Full Text:
- Date Issued: 2015
- Authors: Sotshangane, Nkosinathi Owen
- Date: 2015
- Subjects: Capacity development -- Research Research -- Higher education Research development -- Study and teaching -- South Africa Education, higher -- Action Research -- South Africa
- Language: English
- Type: Thesis , Doctoral , D Ed
- Identifier: http://hdl.handle.net/11260/901 , vital:30009
- Description: This study was originally undertaken to change and improve the way I do my practice at Walter Sisulu University as a Research Associate whose responsibility is to facilitate research capacity development and research excellence within the University, amongst academics and postgraduate students. The success of the Research Resource Centre that I manage depends on the way I promote research culture and research productivity amongst academics and postgraduate students. According to Leedy and Ormrod (2013, p. 2), research is a systematic process that is used to collect, analyse, and interpret data in order to increase my understanding of the phenomenon about interest and concern about a given/identified phenomenon. In this case my own practice changed and improved for the better. The main objective of this study, therefore, was to examine the reasons behind the decline in research productivity in terms of research output and how this could be reversed through action research study intervention in order to enhance research productivity at Walter Sisulu University (WSU). The Department of Higher Education and Training’s (DHET) allocation of research output units for WSU indicated that there was a decline in research output from 2005 to 2010. The extent to which my practice improvement could contribute towards changing or improving research productivity was a question which this study addressed through a quantitative, qualitative and self-reflective action research cyclic inquiry. I organized sample strategies of this study as follows: For quantitative data, I used 120 lecturers as my respondents through questionnaires (females = 47 and males = 73) who were randomly selected; For qualitative data, I used 24 lecturers as respondents who were randomly selected with whom I conducted interviews; and For self-reflective action research cyclic inquiry I used 7 Transformative Education/al Studies (TES) project group members as my focus group. My research findings concluded that the heavy teaching workload at WSU was problematic and lecturers/academics could not devote time to do research. My recommendation is that research should be made compulsory so that academics become aware that at least one or two published articles are required from them, for the benefit of annual university research productivity. Some research participants also recommended that the Research Resource Centre must include programs that focus directly on active participation in research in order to increase the capacity of individual researchers so as to build a critical mass of competent researchers, perhaps by even including incentives as a reward for doing research. According to Koshy (2010), action research is a specific method of conducting research by professionals and practitioners with the ultimate aim of improving practice. My new knowledge, therefore, in respect of how a concerned Research Associate, from a Historically Disadvantaged Institution (HDI), provided the impetus to create a collaborative practice in a higher education institution which was forced to merge with two former technikons (which lacked understanding of what a university means by research productivity and research output). I consequently developed the Nkosinathi Sotshangane’s cyclic practice improvement model through self-reflective action research, from which I believed other research practitioners could learn by doing something similar in their own context.
- Full Text:
- Date Issued: 2015
Molecular characterization, antibiograms and activity of medicinal plants against streptococcus pneumoniae and haemophilus influenzae isolates from clinical samples of patients in the Eastern Cape province, South Africa
- Authors: Morobe, Isaac Christopher
- Date: 2015-00
- Subjects: Medicinal plants
- Language: English
- Type: Master's/Doctoral theses , text
- Identifier: http://hdl.handle.net/11260/6469 , vital:46340
- Description: H. influenzae and S. pneumoniae are important causes of community acquired respiratory tract infections including, pneumonia, acute sinusitis, otitis media, meningitis, bacteremia, sepsis, osteomyelitis, pericarditis, septic arthritis, endocarditis, peritonitis, cellulitis and brain abscesses. The ability to effectively treat bacterial infections has been compromised in recent years due to the acquisition of antibiotic resistance, particularly to β-lactam drugs. The increasing trends in antibiotic resistance have prompted incessant searches aimed at unraveling new effective sources for the management of microbial infections. Plant derived antimicrobial compounds that have no or minimal toxicity to host cells are considered candidates for developing new antimicrobial drugs. Safety is therefore critical in the development and formulation of such antimicrobials. In addition to studies on the structural elucidation of active compounds of selected medicinal plants and determination of their toxicity levels, concerted investigations on the molecular landscape of the designated bacteria, including genes coding for resistance and virulence, the phylogenetic profiles of isolates from different sources and the abilities of isolates to withstand the normal bactericidal activities of human serum samples from different blood groups are critical for a thorough understanding of the management, pathogenetic and clinico- epidemiological trajectories of the pathogens. Therefore, the aims of the various studies were to characterize local H. influenzae and S. pneumoniae isolates by serological and molecular methods; ascertain the antibiotic susceptibility profiles of isolates in order to provide updated data and guide clinicians and other health care workers on the empiric management of patients; determine genes coding for virulence and phylogenetic relatedness of isolates of H. influenzae and S. pneumoniae from diverse sources; ascertain the bactericidal activity of human serum samples from different blood groups against H. influenzae and S. pneumoniae and also to determine the activity of active compounds and toxicity levels of selected medicinal plants. In order to achieve these goals, relevant samples were collected and screened using an array of microbiological, serological, molecular and phytochemical methods, which would be espoused in the relevant chapters, presented hereunder. Key findings of the various chapters including their contributions to knowledge are highlighted. The studies are presented in eight chapters and each chapter, with the exception of chapter one (General Introduction and Literature Review) consists of an introduction, materials and methods, results, discussions, conclusions and references. Each chapter is therefore designed as a publishable unit. Chapter 1 gives an account of the background to the study and the literature review. The morphology, cultural characteristics, laboratory diagnosis, pathogenesis, antibiogram and clinical manifestations of H. influenzae and S. pneumoniae were reviewed. Furthermore, the activities of medicinal plants and their various applications in the management of infections in different countries, including their possible active compounds and toxicity levels were also explored in order to provide a suitable background for the study. Similar reviews were undertaken for molecular aspects of both pathogens as well as the activities of human serum samples against microbial infections. In Chapter 2 the prevalence and antibiotic resistance profiles of H. influenzae and, S. pneumoniae isolates from clinical samples of patients in Mthatha, Eastern Cape Province were investigated. Clinical samples were obtained randomly from individuals attending different hospitals in Mthatha district. Samples were analysed using the Kirby Bauer disk diffusion test (antibiotic susceptibility testing) and MIC breakpoints were determined using E-test strips. From a total of 475 clinical samples tested, 323 (68.0%) were positive for both H. influenzae and S. pneumoniae. Most of the positive isolates were obtained from children under 9 years. Out of 323 isolates, 187 (57.89%) were positive for H. influenzae and 136 (42.1%) were positive for S. pneumoniae. From 10 hospitals selected for sampling in this study, Mthatha General Hospital recorded the highest number of isolates, 42 (25.15%) and 31 (22.79%) of H. influenzae and S. pneumoniae positive isolates respectively, followed by Nelson Mandela Academic Hospital 33 (19.76%) and 26 (19.12%) respectively while ST. Patricks 8 (4.79%) recorded the least number of isolates for H. influenzae and Khotsong 4 (2.94%) recorded the least number of isolates for S. pneumoniae. Antibiotic susceptibility tests revealed Amoxicillin (MIC50, 0.125μg/ml) and Vancomycin (MIC50,0.12μg/ml) as the most effective antibiotics against S. pneumoniae isolates and Co-amoxiclav (MIC50,0.3µg/ml) and Cefuroxime (MIC50,0.15µg/ml) against H. influenzae isolates. These data highlight the need for education and to consider predominant resistance when choosing empiric therapies to treat bacterial infections. Chapter 3 was designed to investigate the virulence factors of H. influenzae and S. pneumoniae isolates from clinical specimens of patients with respiratory tract infections in Mthatha district, the Eastern Cape Province. PCR and sequencing methods were used to verify the genetic determinants responsible for virulence in H. influenzae and S. pneumoniae strains. Results indicated that, of the 187 H. influenzae isolates studied, 26 (13.9%) were typeable, positive by genotypic determination, while 161 (86.1%) were non typeable (NTHi) strains. On the other, out of the 136 S. pneumoniae isolates 24 (17.6%) were typeable while 112 (82.4%) were non typeable strains. All isolates tested contained the metS2 gene for both H. influenzae and S. pneumoniae. The phylogenetic clusters identified by maximum-parsimony analysis were also compared to the results of 16S rRNA sequences. Twenty five percent of none typeable strains were typed by 16S rRNA sequencing. The phylogenetic tree yielded 7.7% H. influenzae similarities while S. pneumoniae yielded 25% similarities with other typeable strains. The presence of genes coding for virulence in this study suggest a significant contribution of genes encoding for virulence to antimicrobial resistance among respiratory tract organisms studied. This study underlines the importance of understanding the virulence composition and diversity of pathogens for enhanced clinico-epidemiological monitoring and health care delivery. The findings will also provide a genetic foundation for future research into mechanisms of pathogenesis of H. influenzae and S. pneumoniae and may accelerate the development of safe and effective vaccines to prevent and control diseases caused by H. influenzae and S. pneumoniae. In Chapter 4, cytotoxic effects and safety profiles of extracts of active medicinal plants from the OR Tambo District Municipality in the Eastern Cape of South Africa were carried out. The most prominent families of medicinal plants (Solanacea and Euphorbiaceae) were used. Extracts of nine South African medicinal plants were screened for cytotoxic activities against MAGI CC5+ cells using MTT assay. Results indicated that nine plant extracts (methanolic and aqueous) used in the MTT assay revealed Herb 2 (Cyanthula inculata) as the most potent extract identified with activity of 1.4 Cc50 values of 25.6 mg/mL and induced over 50% of cell deaths, followed by herb 3 (Croton grattismus) and Herb 4 (Cassine trasvaalensis) with activity of 0.2 Cc50 values of 3.7 mg/mL each. The herbs that induced the least cell death, were herbs 5 (Capris tomentosa) and 7 (Hypoxis hemerocallidea), with the activity of 0.05 Cc50 values of 0.9 mg/mL each. Of the nine plant extracts 2(22%) exhibited minimal toxicity on MAGI cells and 7(77.8%) exhibited 50% toxicity. Two (22%) of the methanolic extracts exhibited anti-HIV1 IIIB activities and against Mycobacterium tuberculosis (TB) only one medicinal plant extract (Lysium inerme) exhibited 29% activity. Cytotoxicity tests will provide comprehensive reference data bases for the profiling and eventual considerations of medicinal plants as potential templates for drug designs and medical applications. In chapter 5 Chemical Components of the volatile and non-volatile extractives of Croton species and their microbial activities were screened. Isolation of the essential oils from the leaves of Croton pseudopulchellus and C. gratissimus from the Eastern Cape and KwaZulu-Natal Provinces in South Africa were performed using an all glass Clevenger apparatus according to the British Pharmacopeia method. The minimum inhibitory concentrations of the oils were assessed against the seven different standard strains of bacteria: H. influenzae, Bacillus pimitus, Staphylococcus aureus, S. pneumoniae, Escherichia coli, Klebsiella pneumoniae, Serratia marcescens and Entarobacter cloacae using micro dilution technique on a 96 well microtitre plate. Results showed golden to very light yellow oils obtained with percentage yield of 1.03 -1.25 respectively (w/w). Analysis of the oils was performed using Gas Chromatography and Gas Chromatography/Mass Spectrophotometry. The leaf oil of Croton pseudopulchellus had germacrene (24.2%),β-phellandrene (17.4%), myrcene (13.4%) and β-caryophyllene (11.4%) as the prominent compounds identified in the oil. The chemical composition of the leaf oil of C. gratissimus was characterized by sabinene (14.6%), β-phellandrene (12.3%), α-phellandrene (10.7%), α-pinene (6.0%) and germacrene D (5.9%). Chemical profiles of the essential oils of Croton species reported in literatures are specific to their geographical location. The oils from C. pseudopulchellus and C. grattisimus were found to have significant antibacterial activities and therefore could be used as natural antimicrobial agents for the treatment of several infectious diseases caused by pathogenic and antibiotic resistant organisms. Chapters 6 and 7 were designed to isolate two bioactive compounds from the stem bark of Lycium inerme and the leaves of Croton grattisimus and were screened for their biological activities against H. influenzae and S. pneumoniae. A qualitative phytochemical screening and bioassay of the plants extracts was carried out. Antimicrobial screening was by broth microdilution and bioautography. Bioassay results showed that compounds with Rf –values between 0.67 to 0.80 were very active against H. influenzae and S. pneumoniae. However, the most active of these compounds was observed at 0.70 for H. influenzae and 0.69 for S. pneumoniae from the dichloromethane extract. Column chromatography, Preparative Thin Layer Chromatography (PTLC) and Sephadex LH20 were used for isolation, sample clean-up and purification of this extract. Two active compounds: a coumarin (7-hydroxy-6-methoxy-coumarin) and two triterpenoids, Ursolic acid (3-oxo-19-hydroxyl-6-methoxylpomolic acid) and Moronic acid (3-oxoolean-12-en-28-oic acid) were isolated from the dichloromethane fraction. The presence of Coumarins and Terpenoids in this herb was observed from the TLC fingerprints. NMR spectroscopic methods were used for the structural elucidation of the active compounds while the GC-MS was used to determine the presence of essential oils from volatile samples obtained from the leaves of C. grattisimus and L. inerme. C. grattisimus extracts possess strong free radicals with scavenging, antimicrobial and antifungal activities; therefore, further studies are needed to determine their efficacies in vivo or clinical usefulness. L. inerme stem bark can therefore be used as a source of alternative medicine or new pharmaceutical and health care product or as a starting material for synthesis of drugs. In chapter 8, general conclusions and perspectives of various parts of the findings were captured. The multi-drug resistance was observed among the emerging respiratory tract bacterial pathogens. It was recommended that measures should be put in place to control the spread of drug resistance in pathogens through improved and standardized laboratory practices, proper and regular surveillance to help guide against the indiscriminate use of antibiotics in empirical treatment. The recognition but cautious use of medicinal plants as alternative sources of therapies and a probable means to solve the emerging resistance problem was recommended. Improved standard of hygiene in hospital settings and the communities is important to prevent the spread of infections. The thesis provides a novel reference document on the genes coding for resistance, antibiograms and phylogenetic profiles of local isolates of H. influenzae and S. pneumoniae as well as the activities, active compounds and toxicity levels of medicinal plants investigated in an endeavour to effectively understand the possible therapeutic, molecular and epidemiological trends in respect of the designated pathogens. , Thesis (Phd) -- Faculty of Health Sciences, 2015
- Full Text:
- Date Issued: 2015-00
- Authors: Morobe, Isaac Christopher
- Date: 2015-00
- Subjects: Medicinal plants
- Language: English
- Type: Master's/Doctoral theses , text
- Identifier: http://hdl.handle.net/11260/6469 , vital:46340
- Description: H. influenzae and S. pneumoniae are important causes of community acquired respiratory tract infections including, pneumonia, acute sinusitis, otitis media, meningitis, bacteremia, sepsis, osteomyelitis, pericarditis, septic arthritis, endocarditis, peritonitis, cellulitis and brain abscesses. The ability to effectively treat bacterial infections has been compromised in recent years due to the acquisition of antibiotic resistance, particularly to β-lactam drugs. The increasing trends in antibiotic resistance have prompted incessant searches aimed at unraveling new effective sources for the management of microbial infections. Plant derived antimicrobial compounds that have no or minimal toxicity to host cells are considered candidates for developing new antimicrobial drugs. Safety is therefore critical in the development and formulation of such antimicrobials. In addition to studies on the structural elucidation of active compounds of selected medicinal plants and determination of their toxicity levels, concerted investigations on the molecular landscape of the designated bacteria, including genes coding for resistance and virulence, the phylogenetic profiles of isolates from different sources and the abilities of isolates to withstand the normal bactericidal activities of human serum samples from different blood groups are critical for a thorough understanding of the management, pathogenetic and clinico- epidemiological trajectories of the pathogens. Therefore, the aims of the various studies were to characterize local H. influenzae and S. pneumoniae isolates by serological and molecular methods; ascertain the antibiotic susceptibility profiles of isolates in order to provide updated data and guide clinicians and other health care workers on the empiric management of patients; determine genes coding for virulence and phylogenetic relatedness of isolates of H. influenzae and S. pneumoniae from diverse sources; ascertain the bactericidal activity of human serum samples from different blood groups against H. influenzae and S. pneumoniae and also to determine the activity of active compounds and toxicity levels of selected medicinal plants. In order to achieve these goals, relevant samples were collected and screened using an array of microbiological, serological, molecular and phytochemical methods, which would be espoused in the relevant chapters, presented hereunder. Key findings of the various chapters including their contributions to knowledge are highlighted. The studies are presented in eight chapters and each chapter, with the exception of chapter one (General Introduction and Literature Review) consists of an introduction, materials and methods, results, discussions, conclusions and references. Each chapter is therefore designed as a publishable unit. Chapter 1 gives an account of the background to the study and the literature review. The morphology, cultural characteristics, laboratory diagnosis, pathogenesis, antibiogram and clinical manifestations of H. influenzae and S. pneumoniae were reviewed. Furthermore, the activities of medicinal plants and their various applications in the management of infections in different countries, including their possible active compounds and toxicity levels were also explored in order to provide a suitable background for the study. Similar reviews were undertaken for molecular aspects of both pathogens as well as the activities of human serum samples against microbial infections. In Chapter 2 the prevalence and antibiotic resistance profiles of H. influenzae and, S. pneumoniae isolates from clinical samples of patients in Mthatha, Eastern Cape Province were investigated. Clinical samples were obtained randomly from individuals attending different hospitals in Mthatha district. Samples were analysed using the Kirby Bauer disk diffusion test (antibiotic susceptibility testing) and MIC breakpoints were determined using E-test strips. From a total of 475 clinical samples tested, 323 (68.0%) were positive for both H. influenzae and S. pneumoniae. Most of the positive isolates were obtained from children under 9 years. Out of 323 isolates, 187 (57.89%) were positive for H. influenzae and 136 (42.1%) were positive for S. pneumoniae. From 10 hospitals selected for sampling in this study, Mthatha General Hospital recorded the highest number of isolates, 42 (25.15%) and 31 (22.79%) of H. influenzae and S. pneumoniae positive isolates respectively, followed by Nelson Mandela Academic Hospital 33 (19.76%) and 26 (19.12%) respectively while ST. Patricks 8 (4.79%) recorded the least number of isolates for H. influenzae and Khotsong 4 (2.94%) recorded the least number of isolates for S. pneumoniae. Antibiotic susceptibility tests revealed Amoxicillin (MIC50, 0.125μg/ml) and Vancomycin (MIC50,0.12μg/ml) as the most effective antibiotics against S. pneumoniae isolates and Co-amoxiclav (MIC50,0.3µg/ml) and Cefuroxime (MIC50,0.15µg/ml) against H. influenzae isolates. These data highlight the need for education and to consider predominant resistance when choosing empiric therapies to treat bacterial infections. Chapter 3 was designed to investigate the virulence factors of H. influenzae and S. pneumoniae isolates from clinical specimens of patients with respiratory tract infections in Mthatha district, the Eastern Cape Province. PCR and sequencing methods were used to verify the genetic determinants responsible for virulence in H. influenzae and S. pneumoniae strains. Results indicated that, of the 187 H. influenzae isolates studied, 26 (13.9%) were typeable, positive by genotypic determination, while 161 (86.1%) were non typeable (NTHi) strains. On the other, out of the 136 S. pneumoniae isolates 24 (17.6%) were typeable while 112 (82.4%) were non typeable strains. All isolates tested contained the metS2 gene for both H. influenzae and S. pneumoniae. The phylogenetic clusters identified by maximum-parsimony analysis were also compared to the results of 16S rRNA sequences. Twenty five percent of none typeable strains were typed by 16S rRNA sequencing. The phylogenetic tree yielded 7.7% H. influenzae similarities while S. pneumoniae yielded 25% similarities with other typeable strains. The presence of genes coding for virulence in this study suggest a significant contribution of genes encoding for virulence to antimicrobial resistance among respiratory tract organisms studied. This study underlines the importance of understanding the virulence composition and diversity of pathogens for enhanced clinico-epidemiological monitoring and health care delivery. The findings will also provide a genetic foundation for future research into mechanisms of pathogenesis of H. influenzae and S. pneumoniae and may accelerate the development of safe and effective vaccines to prevent and control diseases caused by H. influenzae and S. pneumoniae. In Chapter 4, cytotoxic effects and safety profiles of extracts of active medicinal plants from the OR Tambo District Municipality in the Eastern Cape of South Africa were carried out. The most prominent families of medicinal plants (Solanacea and Euphorbiaceae) were used. Extracts of nine South African medicinal plants were screened for cytotoxic activities against MAGI CC5+ cells using MTT assay. Results indicated that nine plant extracts (methanolic and aqueous) used in the MTT assay revealed Herb 2 (Cyanthula inculata) as the most potent extract identified with activity of 1.4 Cc50 values of 25.6 mg/mL and induced over 50% of cell deaths, followed by herb 3 (Croton grattismus) and Herb 4 (Cassine trasvaalensis) with activity of 0.2 Cc50 values of 3.7 mg/mL each. The herbs that induced the least cell death, were herbs 5 (Capris tomentosa) and 7 (Hypoxis hemerocallidea), with the activity of 0.05 Cc50 values of 0.9 mg/mL each. Of the nine plant extracts 2(22%) exhibited minimal toxicity on MAGI cells and 7(77.8%) exhibited 50% toxicity. Two (22%) of the methanolic extracts exhibited anti-HIV1 IIIB activities and against Mycobacterium tuberculosis (TB) only one medicinal plant extract (Lysium inerme) exhibited 29% activity. Cytotoxicity tests will provide comprehensive reference data bases for the profiling and eventual considerations of medicinal plants as potential templates for drug designs and medical applications. In chapter 5 Chemical Components of the volatile and non-volatile extractives of Croton species and their microbial activities were screened. Isolation of the essential oils from the leaves of Croton pseudopulchellus and C. gratissimus from the Eastern Cape and KwaZulu-Natal Provinces in South Africa were performed using an all glass Clevenger apparatus according to the British Pharmacopeia method. The minimum inhibitory concentrations of the oils were assessed against the seven different standard strains of bacteria: H. influenzae, Bacillus pimitus, Staphylococcus aureus, S. pneumoniae, Escherichia coli, Klebsiella pneumoniae, Serratia marcescens and Entarobacter cloacae using micro dilution technique on a 96 well microtitre plate. Results showed golden to very light yellow oils obtained with percentage yield of 1.03 -1.25 respectively (w/w). Analysis of the oils was performed using Gas Chromatography and Gas Chromatography/Mass Spectrophotometry. The leaf oil of Croton pseudopulchellus had germacrene (24.2%),β-phellandrene (17.4%), myrcene (13.4%) and β-caryophyllene (11.4%) as the prominent compounds identified in the oil. The chemical composition of the leaf oil of C. gratissimus was characterized by sabinene (14.6%), β-phellandrene (12.3%), α-phellandrene (10.7%), α-pinene (6.0%) and germacrene D (5.9%). Chemical profiles of the essential oils of Croton species reported in literatures are specific to their geographical location. The oils from C. pseudopulchellus and C. grattisimus were found to have significant antibacterial activities and therefore could be used as natural antimicrobial agents for the treatment of several infectious diseases caused by pathogenic and antibiotic resistant organisms. Chapters 6 and 7 were designed to isolate two bioactive compounds from the stem bark of Lycium inerme and the leaves of Croton grattisimus and were screened for their biological activities against H. influenzae and S. pneumoniae. A qualitative phytochemical screening and bioassay of the plants extracts was carried out. Antimicrobial screening was by broth microdilution and bioautography. Bioassay results showed that compounds with Rf –values between 0.67 to 0.80 were very active against H. influenzae and S. pneumoniae. However, the most active of these compounds was observed at 0.70 for H. influenzae and 0.69 for S. pneumoniae from the dichloromethane extract. Column chromatography, Preparative Thin Layer Chromatography (PTLC) and Sephadex LH20 were used for isolation, sample clean-up and purification of this extract. Two active compounds: a coumarin (7-hydroxy-6-methoxy-coumarin) and two triterpenoids, Ursolic acid (3-oxo-19-hydroxyl-6-methoxylpomolic acid) and Moronic acid (3-oxoolean-12-en-28-oic acid) were isolated from the dichloromethane fraction. The presence of Coumarins and Terpenoids in this herb was observed from the TLC fingerprints. NMR spectroscopic methods were used for the structural elucidation of the active compounds while the GC-MS was used to determine the presence of essential oils from volatile samples obtained from the leaves of C. grattisimus and L. inerme. C. grattisimus extracts possess strong free radicals with scavenging, antimicrobial and antifungal activities; therefore, further studies are needed to determine their efficacies in vivo or clinical usefulness. L. inerme stem bark can therefore be used as a source of alternative medicine or new pharmaceutical and health care product or as a starting material for synthesis of drugs. In chapter 8, general conclusions and perspectives of various parts of the findings were captured. The multi-drug resistance was observed among the emerging respiratory tract bacterial pathogens. It was recommended that measures should be put in place to control the spread of drug resistance in pathogens through improved and standardized laboratory practices, proper and regular surveillance to help guide against the indiscriminate use of antibiotics in empirical treatment. The recognition but cautious use of medicinal plants as alternative sources of therapies and a probable means to solve the emerging resistance problem was recommended. Improved standard of hygiene in hospital settings and the communities is important to prevent the spread of infections. The thesis provides a novel reference document on the genes coding for resistance, antibiograms and phylogenetic profiles of local isolates of H. influenzae and S. pneumoniae as well as the activities, active compounds and toxicity levels of medicinal plants investigated in an endeavour to effectively understand the possible therapeutic, molecular and epidemiological trends in respect of the designated pathogens. , Thesis (Phd) -- Faculty of Health Sciences, 2015
- Full Text:
- Date Issued: 2015-00
Negotiation of Sex: A Study on Prevention Methods of Gender Based Violence amongst Intimate Partners of Ntabankulu
- Authors: Mketi, Funeka Gloria
- Date: 2014-10
- Subjects: Violent Crimes
- Language: English
- Type: Masters theses , text
- Identifier: http://hdl.handle.net/11260/7550 , vital:54348
- Description: ABSTRACT The purpose of the study was to investigate whether negotiation of sex between intimate partners can be used as a prevention strategy of gender-based violence. The study included both female and male participants. Availability sampling technique was used to select the sample size of thirty. Participants were recruited from the street and data was collected in a private office. Participant’s ethical rights to confidentiality, anonymity, voluntary participation, and informed consent obtained prior taking part in the study were highly respected. Thirty questionnaires were used to collect data. Nature and prevalence of gender-based violence, attitudes, mechanisms and processes involved in negotiation of sex, and prevention strategies were investigated. Data was analyzed using Statistical Package of Social Sciences (SPSS) version 21.0. SPSS analyzed and summarized data into tables. Findings showed that prevalence of gender-based violence (GBV) in intimate partners is high. Negotiation of sex can be used as one of the prevention strategies, and the available processes and mechanisms of negotiating sex should be strengthened. Results also revealed that women empowerment in education and interventions focused on changing men’s attitude towards negotiation can help. Lastly, it appears that there is a need for capacitating both females and males with negotiation skills. , Thesis (Masters) -- Faculy of Humanities, Social Sciences and Law, 2014
- Full Text:
- Date Issued: 2014-10
- Authors: Mketi, Funeka Gloria
- Date: 2014-10
- Subjects: Violent Crimes
- Language: English
- Type: Masters theses , text
- Identifier: http://hdl.handle.net/11260/7550 , vital:54348
- Description: ABSTRACT The purpose of the study was to investigate whether negotiation of sex between intimate partners can be used as a prevention strategy of gender-based violence. The study included both female and male participants. Availability sampling technique was used to select the sample size of thirty. Participants were recruited from the street and data was collected in a private office. Participant’s ethical rights to confidentiality, anonymity, voluntary participation, and informed consent obtained prior taking part in the study were highly respected. Thirty questionnaires were used to collect data. Nature and prevalence of gender-based violence, attitudes, mechanisms and processes involved in negotiation of sex, and prevention strategies were investigated. Data was analyzed using Statistical Package of Social Sciences (SPSS) version 21.0. SPSS analyzed and summarized data into tables. Findings showed that prevalence of gender-based violence (GBV) in intimate partners is high. Negotiation of sex can be used as one of the prevention strategies, and the available processes and mechanisms of negotiating sex should be strengthened. Results also revealed that women empowerment in education and interventions focused on changing men’s attitude towards negotiation can help. Lastly, it appears that there is a need for capacitating both females and males with negotiation skills. , Thesis (Masters) -- Faculy of Humanities, Social Sciences and Law, 2014
- Full Text:
- Date Issued: 2014-10
AN ETHNOGRAPHIC STUDY ON MEANINGS CREATED WHEN BEADWORK IS USED FOR RESTORATION OF AFRICAN ETHNIC IDENTITY: A CASE OF ABATHEMBU FROM QUNU VILLAGE, EASTERN CAPE PROVINCE, SOUTH AFRICA
- Authors: ROZANI CARINA NOMFUZO
- Date: 2014
- Subjects: RESTORATION OF AFRICAN ETHNIC IDENTITY, BEADWORK
- Language: English
- Type: Masters, MA
- Identifier: http://hdl.handle.net/11260/2377 , vital:41453
- Description: This study is an assessment on the meanings created when beadwork is used for restoration of African identity among AbaThembu. The research site is Qunu village. The research presents some insights on learners and community members’ perceptions towards integration of beadwork (IK) into the formal curricula. The results further respond to questions on how respondents think beadwork can be used for restoration of ethnic identity, and its possible inclusion into the school curricula. Questions surrounding the complex relations arising from an interface between indigenous knowledge and Eurocentric ideals are answered. The importance of the study is its potential to present knowledge on the identities created when beadwork is used for restoration of ethnic identity. A structured interview schedule was administered at selected schools and this was complemented by in-depth interviews which involved learners and parents. Ethnography and observation also featured. Photographic documentation of beadwork was also done. Learners were targeted due to wide assumptions that the young generation shun indigenous lifestyles. Quantitative data was analyzed using Statistical Package for Social Sciences (SPSS) IBM 20 version while qualitative data was analyzed manually. The study was underpinned by frameworks founded on Critical Theory which seeks to interpret social aspects from a constructivist point of view. In that regard people’s day to day activities are upheld as key in understanding their way of life and dealing with challenges they encounter(Guess, 1981). Specifically, the Kaupapa Maori theory developed in New Zealand was used. Although it is rooted in arguments highlighting the Maori worldviews, philosophical foundations, cultural values and languages it was found useful in interpreting the state of indigenous knowledge usage in the South African context (Smith, 1999). EZiko siPheka siSophula theoretical framework was further used to interprete social aspects in the study. It was found to be appropriate because it explains issues from a holistic, relational and participatory angle (Goduka, 2012). Findings revealed complexities facing customary practices in the modern context amid different perceptions held towards reliance on the practices to restore ethnic identity. The study noted that through curricula transformation, it could be possible that identities representing abaThembu culture can be re-invented to suit the modern context and appeal to the younger generation. One of the key recommendations includes infusion of indigenous activities such as beadwork into modern institutions like education in efforts to promote people’s identities and beadwork entrepreneurship to sustain livelihoods.
- Full Text:
- Authors: ROZANI CARINA NOMFUZO
- Date: 2014
- Subjects: RESTORATION OF AFRICAN ETHNIC IDENTITY, BEADWORK
- Language: English
- Type: Masters, MA
- Identifier: http://hdl.handle.net/11260/2377 , vital:41453
- Description: This study is an assessment on the meanings created when beadwork is used for restoration of African identity among AbaThembu. The research site is Qunu village. The research presents some insights on learners and community members’ perceptions towards integration of beadwork (IK) into the formal curricula. The results further respond to questions on how respondents think beadwork can be used for restoration of ethnic identity, and its possible inclusion into the school curricula. Questions surrounding the complex relations arising from an interface between indigenous knowledge and Eurocentric ideals are answered. The importance of the study is its potential to present knowledge on the identities created when beadwork is used for restoration of ethnic identity. A structured interview schedule was administered at selected schools and this was complemented by in-depth interviews which involved learners and parents. Ethnography and observation also featured. Photographic documentation of beadwork was also done. Learners were targeted due to wide assumptions that the young generation shun indigenous lifestyles. Quantitative data was analyzed using Statistical Package for Social Sciences (SPSS) IBM 20 version while qualitative data was analyzed manually. The study was underpinned by frameworks founded on Critical Theory which seeks to interpret social aspects from a constructivist point of view. In that regard people’s day to day activities are upheld as key in understanding their way of life and dealing with challenges they encounter(Guess, 1981). Specifically, the Kaupapa Maori theory developed in New Zealand was used. Although it is rooted in arguments highlighting the Maori worldviews, philosophical foundations, cultural values and languages it was found useful in interpreting the state of indigenous knowledge usage in the South African context (Smith, 1999). EZiko siPheka siSophula theoretical framework was further used to interprete social aspects in the study. It was found to be appropriate because it explains issues from a holistic, relational and participatory angle (Goduka, 2012). Findings revealed complexities facing customary practices in the modern context amid different perceptions held towards reliance on the practices to restore ethnic identity. The study noted that through curricula transformation, it could be possible that identities representing abaThembu culture can be re-invented to suit the modern context and appeal to the younger generation. One of the key recommendations includes infusion of indigenous activities such as beadwork into modern institutions like education in efforts to promote people’s identities and beadwork entrepreneurship to sustain livelihoods.
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An investigation into second language Learners’ proficiency in Mathematical language
- Authors: Ngibe, Ntsikelelo Hector
- Date: 2014
- Subjects: Second language acquisition -- Teaching and learning -- Mathematics Mathematics -- Language -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , M Ed
- Identifier: http://hdl.handle.net/11260/845 , vital:29936
- Description: The purpose of the study was to investigate second language learner‟s proficiency in mathematical language. The study was conducted using the Grade 12 learners in a senior secondary school in the district of Mthatha, Eastern Cape. The researcher used a case study approach and a questionnaire was used to investigate whether or not learners understood the language rather than to assess their mathematical ability. English was the language in question and used as the medium of instruction (MOI). In this study, aspects of the language used for mathematics are highlighted, the importance of mathematical vocabulary is discussed and reference is made to some recent research concerned with the understanding of mathematical language. The importance of language as a factor in the learning of mathematics is established through a consideration of bilingualism and the writer‟s own research into the understanding of mathematical language. Perhaps the most obvious educational difficulty which students encounter is that of language. Teachers and curriculum planners need to assess whether this is desirable, and to attempt to find ways in which learners in bilingual education programmes can learn mathematics in a meaningful way. Theories on the interaction between language and mathematical thinking, as well as the studies conducted with bilingual students can inform one‟s thinking about this issue. These ideas have important implications for teaching, texts and curriculum development. The study examined some of the above aspects in the context of South African Education.
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- Date Issued: 2014
- Authors: Ngibe, Ntsikelelo Hector
- Date: 2014
- Subjects: Second language acquisition -- Teaching and learning -- Mathematics Mathematics -- Language -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , M Ed
- Identifier: http://hdl.handle.net/11260/845 , vital:29936
- Description: The purpose of the study was to investigate second language learner‟s proficiency in mathematical language. The study was conducted using the Grade 12 learners in a senior secondary school in the district of Mthatha, Eastern Cape. The researcher used a case study approach and a questionnaire was used to investigate whether or not learners understood the language rather than to assess their mathematical ability. English was the language in question and used as the medium of instruction (MOI). In this study, aspects of the language used for mathematics are highlighted, the importance of mathematical vocabulary is discussed and reference is made to some recent research concerned with the understanding of mathematical language. The importance of language as a factor in the learning of mathematics is established through a consideration of bilingualism and the writer‟s own research into the understanding of mathematical language. Perhaps the most obvious educational difficulty which students encounter is that of language. Teachers and curriculum planners need to assess whether this is desirable, and to attempt to find ways in which learners in bilingual education programmes can learn mathematics in a meaningful way. Theories on the interaction between language and mathematical thinking, as well as the studies conducted with bilingual students can inform one‟s thinking about this issue. These ideas have important implications for teaching, texts and curriculum development. The study examined some of the above aspects in the context of South African Education.
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- Date Issued: 2014
Biochemical Evaluation Of Pregnant Women Practicing Geophagia With Special Reference To Iron Nutritional Status In The King Sabata Dalindyebo Municipality
- Authors: Abiodun Adams
- Date: 2014
- Language: English
- Identifier: http://hdl.handle.net/11260/2878 , vital:42970 , Geophagia, pregnant women, iron nutritional status, iron-deficiency anaemia.
- Description: Abstract Introduction There is no information on iron deficiency anaemia and ferritin-related oxidative stress as a potential result of geophagia during pregnancy in the King Sabatha Dalyindyebo Municipality, South Africa. Aim The aim of the study was to assess the magnitude of geophagia (soil eating) associated with biochemical and haematological indices of iron nutritional status of pregnant women. Materials and Methods A cross sectional study was carried out among 210 (response rate=95.5% of 220 eligible) pregnant women living in the Mthatha areas of the King Sabata Dalyindebo Municipality attending 3 selected clinics during 2012. Data (socio-demographic, geophagia, haematological indices, serum iron and transferrin saturation) were analyzed using univariate analysis (mean, proportions, percentiles, Odd Ratio and 95%CI, ANOVA and chi-square) and multivariate analysis (Odd Ratio and 95% CI and logistic regression model) was performed. P-Value <0.05 was significant. Results In all cases, 98.6% (n=207) and 100% (n=210) defined by serum iron ≤ 30µmol/l and <40µmol/l, presented with iron deficiency, respectively. However, iron deficiency, defined by serum ferritin <12µg/l and by transferrin saturation <16%, was present in 25.7% (n=54) and 61.9% (n=130) of all cases, respectively. Iron-deficiency anaemia was present in 51.4% (n=108) and 18.6% (n=39) using WHO haemoglobin and serum iron cut-offs and WHO haemoglobin and serum ferritin cut-offs, respectively. However,ii 37.1% (n=78/210) had an iron deficiency, defined by serum iron <10 µmol/l and 30.5% (n=64/210) defined by transferrin saturation <10%. In geophagics, 98.7% (n=76) had iron-deficiency anaemia (using serum iron cut-offs) whereas only 24.1% (n=32) of non geophagics presented with iron deficiency anaemia. However, using serum ferritin cut-offs, geophagics had iron deficiency anaemia estimated at 69.2% (n=27/59) but non geophagics had iron deficiency anaemia estimated at 30.8% (n=12/39). The optimal cut-offs of serum iron <10 µmol/l and transferrin saturation <10% are the best discriminants of iron deficiency as defined by serum ferritin <12 µg/l. Ferritin-related oxidative stress was present among 24.8% in the study population (the highest quartile of serum ferritin being >30.01 µg/l). The most important factors associated with iron deficiency anaemia in all pregnant women were geophagic behaviour (OR=2.1 95% CI 1.1-4.2; P=0.029), MCHC decreases (<30.5 0R=16.6 95%CI 6.8-40.2; P=0.006) and MCHC decreases (30.5-31.5 OR=2.9 95%CI 1.4-6.1; P=0.006). In all pregnant women, serum iron <14 (OR=6.2 95%CI 1.2-31.7; P=0.030), platelets <228 (OR=3.9 95%CI 1.6-10.8; P=0.008), age ≥28years (OR=4.2 95%CI 1.7-10.4; P=0.002), transferrin saturation ≥18% (OR=51.3 95%CI 8.9-295.2; P=<0.0001), were identified as the most significant independent determinants of ferritin-related oxidative stress. However, increase in age, depletion in iron, decrease in platelet count but increase in transferrin saturation were the significant independent determinants of ferritin-related oxidative stress among geophagic pregnant women (Y=0.282 x Age – 1.007 x iron – 0.023 platelet +0.946 transferrin saturation). In non-geophagic pregnant women, only a decrease in iron and an increase in transferrin saturation were the significant characteristics of ferritin-related oxidative stress (Y=-3.21-0.309 x iron + 0.379 transferrin saturation). Conclusioniii Geophagia induces a high level of anaemia, iron deficiency anaemia and ferritin-related oxidative stress. The most independent determinants of iron deficiency anaemia in all pregnant women were geophagic behaviour and MCHC decrease. Independent and important determinants of ferritin-related oxidative stress in all pregnant women were severe categories of decreased iron and platelets with higher levels of age ≥28 years, transferrin saturation (≥18%)
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- Authors: Abiodun Adams
- Date: 2014
- Language: English
- Identifier: http://hdl.handle.net/11260/2878 , vital:42970 , Geophagia, pregnant women, iron nutritional status, iron-deficiency anaemia.
- Description: Abstract Introduction There is no information on iron deficiency anaemia and ferritin-related oxidative stress as a potential result of geophagia during pregnancy in the King Sabatha Dalyindyebo Municipality, South Africa. Aim The aim of the study was to assess the magnitude of geophagia (soil eating) associated with biochemical and haematological indices of iron nutritional status of pregnant women. Materials and Methods A cross sectional study was carried out among 210 (response rate=95.5% of 220 eligible) pregnant women living in the Mthatha areas of the King Sabata Dalyindebo Municipality attending 3 selected clinics during 2012. Data (socio-demographic, geophagia, haematological indices, serum iron and transferrin saturation) were analyzed using univariate analysis (mean, proportions, percentiles, Odd Ratio and 95%CI, ANOVA and chi-square) and multivariate analysis (Odd Ratio and 95% CI and logistic regression model) was performed. P-Value <0.05 was significant. Results In all cases, 98.6% (n=207) and 100% (n=210) defined by serum iron ≤ 30µmol/l and <40µmol/l, presented with iron deficiency, respectively. However, iron deficiency, defined by serum ferritin <12µg/l and by transferrin saturation <16%, was present in 25.7% (n=54) and 61.9% (n=130) of all cases, respectively. Iron-deficiency anaemia was present in 51.4% (n=108) and 18.6% (n=39) using WHO haemoglobin and serum iron cut-offs and WHO haemoglobin and serum ferritin cut-offs, respectively. However,ii 37.1% (n=78/210) had an iron deficiency, defined by serum iron <10 µmol/l and 30.5% (n=64/210) defined by transferrin saturation <10%. In geophagics, 98.7% (n=76) had iron-deficiency anaemia (using serum iron cut-offs) whereas only 24.1% (n=32) of non geophagics presented with iron deficiency anaemia. However, using serum ferritin cut-offs, geophagics had iron deficiency anaemia estimated at 69.2% (n=27/59) but non geophagics had iron deficiency anaemia estimated at 30.8% (n=12/39). The optimal cut-offs of serum iron <10 µmol/l and transferrin saturation <10% are the best discriminants of iron deficiency as defined by serum ferritin <12 µg/l. Ferritin-related oxidative stress was present among 24.8% in the study population (the highest quartile of serum ferritin being >30.01 µg/l). The most important factors associated with iron deficiency anaemia in all pregnant women were geophagic behaviour (OR=2.1 95% CI 1.1-4.2; P=0.029), MCHC decreases (<30.5 0R=16.6 95%CI 6.8-40.2; P=0.006) and MCHC decreases (30.5-31.5 OR=2.9 95%CI 1.4-6.1; P=0.006). In all pregnant women, serum iron <14 (OR=6.2 95%CI 1.2-31.7; P=0.030), platelets <228 (OR=3.9 95%CI 1.6-10.8; P=0.008), age ≥28years (OR=4.2 95%CI 1.7-10.4; P=0.002), transferrin saturation ≥18% (OR=51.3 95%CI 8.9-295.2; P=<0.0001), were identified as the most significant independent determinants of ferritin-related oxidative stress. However, increase in age, depletion in iron, decrease in platelet count but increase in transferrin saturation were the significant independent determinants of ferritin-related oxidative stress among geophagic pregnant women (Y=0.282 x Age – 1.007 x iron – 0.023 platelet +0.946 transferrin saturation). In non-geophagic pregnant women, only a decrease in iron and an increase in transferrin saturation were the significant characteristics of ferritin-related oxidative stress (Y=-3.21-0.309 x iron + 0.379 transferrin saturation). Conclusioniii Geophagia induces a high level of anaemia, iron deficiency anaemia and ferritin-related oxidative stress. The most independent determinants of iron deficiency anaemia in all pregnant women were geophagic behaviour and MCHC decrease. Independent and important determinants of ferritin-related oxidative stress in all pregnant women were severe categories of decreased iron and platelets with higher levels of age ≥28 years, transferrin saturation (≥18%)
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Challenges facing teachers in implementing alternative measures of discipline in schools: a case study of five secondary schools in the Umzimkhulu circuit of the Sisonke District in Kwazulu-Natal
- Authors: Zulu, Xolani Wycliff
- Date: 2014
- Subjects: School discipline , Secondary schools , Sisonke District -- Kwazulu-Natal, South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/11260/2393 , vital:41455
- Description: This dissertation is a report on a study that was conducted in rural schools of the Sisonke District in KwaZulu-Natal, a province of South Africa. The study covered the challenges experienced by teachers in implementing the alternative measures of discipline. The study was conducted because the researcher was the head of the disciplinary committee in the school where he was employed and he often dealt with disciplinary problems which usually occurred between the teachers, learners and SMTs. It was important to know from other schools, what problems they faced in implementing the alternative measures of discipline. The study used a qualitative research design in the form of a case study. Purposive sampling was used. The sample comprised 15 SMT members, and 20 post level 1 teachers, and the total number of participants was 35. Data was collected through observations which were followed by interviews. Qualitative methods were used to analyse data. This involved reduction and interpretation of data collected. The findings of the study highlighted the role that could be played by SMTs, teachers, parents, and the Department of Education in the smooth running of the school in dealing with the misunderstandings of alternative measures of discipline and so advance an effective work ethos. The study also illuminated the issue of negligence on the part of SMTs in enforcing the implementation of the alternative measures of discipline. There was a great need for school teachers to be well versed in the general legislation of the Department of Education so as to align themselves with the correct rules and regulations when they deal with disciplinary problems. , Thesis (MEd) -- Faculty of Humanities, Educational Management and Policy, 2014
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- Date Issued: 2014
- Authors: Zulu, Xolani Wycliff
- Date: 2014
- Subjects: School discipline , Secondary schools , Sisonke District -- Kwazulu-Natal, South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/11260/2393 , vital:41455
- Description: This dissertation is a report on a study that was conducted in rural schools of the Sisonke District in KwaZulu-Natal, a province of South Africa. The study covered the challenges experienced by teachers in implementing the alternative measures of discipline. The study was conducted because the researcher was the head of the disciplinary committee in the school where he was employed and he often dealt with disciplinary problems which usually occurred between the teachers, learners and SMTs. It was important to know from other schools, what problems they faced in implementing the alternative measures of discipline. The study used a qualitative research design in the form of a case study. Purposive sampling was used. The sample comprised 15 SMT members, and 20 post level 1 teachers, and the total number of participants was 35. Data was collected through observations which were followed by interviews. Qualitative methods were used to analyse data. This involved reduction and interpretation of data collected. The findings of the study highlighted the role that could be played by SMTs, teachers, parents, and the Department of Education in the smooth running of the school in dealing with the misunderstandings of alternative measures of discipline and so advance an effective work ethos. The study also illuminated the issue of negligence on the part of SMTs in enforcing the implementation of the alternative measures of discipline. There was a great need for school teachers to be well versed in the general legislation of the Department of Education so as to align themselves with the correct rules and regulations when they deal with disciplinary problems. , Thesis (MEd) -- Faculty of Humanities, Educational Management and Policy, 2014
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- Date Issued: 2014