African middle class elite
- Authors: Nyquist, Thomas E
- Date: 1983
- Subjects: Black people -- South Africa -- Grahamstown Grahamstown (South Africa) -- History Grahamstown (South Africa) -- Social conditions Social classes -- South Africa -- Grahamstown Black people -- South Africa -- Social conditions Black people -- South Africa -- Grahamstown -- Social conditions Grahamstown African Rugby Union Middle class -- South Africa
- Language: English
- Type: Book , Text
- Identifier: http://hdl.handle.net/10962/2780 , vital:20325 , ISBN 0868100412
- Description: In this time of crucial change for all of Southern Africa - as the former colonies of Portugal struggle to become viable states, as Rhodesia totters on the brink of political change, and as South Africa girds itself for an uncertain future - the question is: “What of the potential African leaders in South Africa?” We hear of the Bantustans and their thrust forward, but what of those Africans of ability living in the urban areas whose counterparts have provided much of the leadership in other African countries? Who are they? What are their circumstances? What are they thinking? And what are they doing? The goal of this study is to suggest tentative answers through the careful and detailed study of a specific community and its potential leaders, the upper stratum. Such answers can only be approximate, of course. Community circumstances differ. Moreover, the explosive events in Soweto and elsewhere in South Africa during 1976 have altered reality, and our study was carried out during 1966-7 and 1975. The locus of research has been Grahamstown and, most particularly, the African community attached to it (see Maps 1 and 2). Situated in the eastern region of the Cape Province, Grahamstown is a city of regional importance, best known as the centre of the first large English settlement1. Arguments about its suitability for research of this nature are detailed in Appendix A, but from the researcher’s perspective its African population of 35 000+ gives it more than local significance while still being small enough to allow a thorough study. In addition, the community’s depth of contact with Europeans going back to the 1830’s, and the general importance of Grahamstown as an educational centre, imply a more sophisticated population than its size might otherwise indicate. Further, the community's nearness to the African Bantustan of the Ciskei, one of nine such “homelands” for Africans, and to the African university at Fort Hare, add to its significance. The primary group under study has been the upper stratum of the African community, as defined by the Africans themselves. From the research has evolved a series of propositions. They relate, first, to the composition of the African upper stratum and the role of its members in their own community, and, second, to the way in which their marginal position within South Africa contributes to particular attitudes and social behaviour often detrimental to the achievement of a better community. (For a discussion of the research techniques used, see Appendix B.) , Digitised by Rhodes University Library on behalf of the Institute of Social and Economic Research (ISER)
- Full Text:
- Date Issued: 1983
- Authors: Nyquist, Thomas E
- Date: 1983
- Subjects: Black people -- South Africa -- Grahamstown Grahamstown (South Africa) -- History Grahamstown (South Africa) -- Social conditions Social classes -- South Africa -- Grahamstown Black people -- South Africa -- Social conditions Black people -- South Africa -- Grahamstown -- Social conditions Grahamstown African Rugby Union Middle class -- South Africa
- Language: English
- Type: Book , Text
- Identifier: http://hdl.handle.net/10962/2780 , vital:20325 , ISBN 0868100412
- Description: In this time of crucial change for all of Southern Africa - as the former colonies of Portugal struggle to become viable states, as Rhodesia totters on the brink of political change, and as South Africa girds itself for an uncertain future - the question is: “What of the potential African leaders in South Africa?” We hear of the Bantustans and their thrust forward, but what of those Africans of ability living in the urban areas whose counterparts have provided much of the leadership in other African countries? Who are they? What are their circumstances? What are they thinking? And what are they doing? The goal of this study is to suggest tentative answers through the careful and detailed study of a specific community and its potential leaders, the upper stratum. Such answers can only be approximate, of course. Community circumstances differ. Moreover, the explosive events in Soweto and elsewhere in South Africa during 1976 have altered reality, and our study was carried out during 1966-7 and 1975. The locus of research has been Grahamstown and, most particularly, the African community attached to it (see Maps 1 and 2). Situated in the eastern region of the Cape Province, Grahamstown is a city of regional importance, best known as the centre of the first large English settlement1. Arguments about its suitability for research of this nature are detailed in Appendix A, but from the researcher’s perspective its African population of 35 000+ gives it more than local significance while still being small enough to allow a thorough study. In addition, the community’s depth of contact with Europeans going back to the 1830’s, and the general importance of Grahamstown as an educational centre, imply a more sophisticated population than its size might otherwise indicate. Further, the community's nearness to the African Bantustan of the Ciskei, one of nine such “homelands” for Africans, and to the African university at Fort Hare, add to its significance. The primary group under study has been the upper stratum of the African community, as defined by the Africans themselves. From the research has evolved a series of propositions. They relate, first, to the composition of the African upper stratum and the role of its members in their own community, and, second, to the way in which their marginal position within South Africa contributes to particular attitudes and social behaviour often detrimental to the achievement of a better community. (For a discussion of the research techniques used, see Appendix B.) , Digitised by Rhodes University Library on behalf of the Institute of Social and Economic Research (ISER)
- Full Text:
- Date Issued: 1983
Alcoholic adaptation : a preliminary investigation of the transactional analysis viewpoint, with application to delta and gamma alcoholics
- Authors: Cohen, L Derek
- Date: 1983
- Subjects: Alcoholism Alcoholism -- Case studies
- Language: English
- Type: Thesis , Masters , MSocSc
- Identifier: vital:3193 , http://hdl.handle.net/10962/d1008559
- Description: Two delta and two gamma alcoholics were assessed by case study according to the theoretical formulations of Transactional Analysis. Scripts and Games were elicited through the Thematic Apperception Test, Laddering Procedure, and Life History. Analyses demonstrated, firstly, that parallels were present between the parent-child relationship and present adult transactions; secondly, that needs, fears, and control mechanisms were traceable to early parental injunctions; thirdly, that among these subjects, delta alcoholics tend to play the alcoholic game "Lush", and gamma alcoholics tend to play the alcoholic game "Drunk and Proud". It was concluded that the script and existential position appear to play an important role in the maintenance of the drinking pattern. Alcoholic Loss of Control appears to be influenced by the degree to which aggression is suppressed.
- Full Text:
- Date Issued: 1983
- Authors: Cohen, L Derek
- Date: 1983
- Subjects: Alcoholism Alcoholism -- Case studies
- Language: English
- Type: Thesis , Masters , MSocSc
- Identifier: vital:3193 , http://hdl.handle.net/10962/d1008559
- Description: Two delta and two gamma alcoholics were assessed by case study according to the theoretical formulations of Transactional Analysis. Scripts and Games were elicited through the Thematic Apperception Test, Laddering Procedure, and Life History. Analyses demonstrated, firstly, that parallels were present between the parent-child relationship and present adult transactions; secondly, that needs, fears, and control mechanisms were traceable to early parental injunctions; thirdly, that among these subjects, delta alcoholics tend to play the alcoholic game "Lush", and gamma alcoholics tend to play the alcoholic game "Drunk and Proud". It was concluded that the script and existential position appear to play an important role in the maintenance of the drinking pattern. Alcoholic Loss of Control appears to be influenced by the degree to which aggression is suppressed.
- Full Text:
- Date Issued: 1983
An assessment of employment opportunities created by the Keiskamma Irrigation Scheme
- Authors: Nightingale, Fiona Mary
- Date: 1983
- Subjects: Economic development projects -- South Africa --Ciskei , Job creation -- South Africa -- Ciskei , Irrigation -- South Africa -- Ciskei , Agriculture -- Economic aspects -- South Africa -- Ciskei , Black people -- Employment -- South Africa -- Ciskei
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:4862 , http://hdl.handle.net/10962/d1006912 , Economic development projects -- South Africa --Ciskei , Job creation -- South Africa -- Ciskei , Irrigation -- South Africa -- Ciskei , Agriculture -- Economic aspects -- South Africa -- Ciskei , Black people -- Employment -- South Africa -- Ciskei
- Description: Preface: "The need for development as observed today is a problem peculiar to the 20th century. The current situation is characterised by the fact that there are no more empty places on the earth, while our use of dwindling resources is curbed by environmental constraint." (Mouly and Costa, 1974, 155). The need for development is not equally felt by all nations as disparities in income and standards of living on a national basis have dissected the world into developed and underdeveloped countries. Disparities also exist within nations. These divisions are not simply determined nor are the terms related to development clearly defined - a matter that will be discussed in Chapter Two. Impetus to developing underdeveloped countries may be provided by various means, such as a general injection of capital or by more specific development projects. The purpose of these projects is to initiate changes that are intended to promote rapid development of an area. An interest has been shown by Geographers in the ability of these projects to stimulate economic growth in surrounding areas (Silberfein, 1976). The resulting success of development projects is closely related, if not determined, in large measure, by the aims. In view of the need for the aims of development projects to be successfully fulfilled, research into what constitute constructive developmental aims would be beneficial. Previous studies have revealed problems encountered with conflicting aims and objectives (Mountjoy, 1971); poorly defined aims (de Wilde, 1967); and inadequate groundwork prior to initiating the project (Berry, 1976). It is the intention of the study to examine the impact made by a development project in an underdeveloped area, and thereby assess the extent to which the development aims have been carried out. In order to carry out an examination of a development project in an underdeveloped area, an area in need of development had to be selected; a project within the area chosen for study; and the particular aim of the project examined. The Ciskei, a Homeland in South Africa, was chosen as a suitable area for study. A number of factors contribute towards it being an area in need of development, particularly as the Ciskei is a small country and dependent on South Africa, which is explained in the overview of the Ciskei in Chapter One. Three characteristics of underdevelopment noted by Seers (1972) are poverty, inequality and underemployment. Of these three factors it was decided to focus on unemployment as the indication of the extent to which development has taken place. The reduction of unemployment was one of the aims of the Keiskammahoek Irrigation Scheme, the project chosen for study. The overview concludes with a presentation of the Keiskamma Irrigation Scheme.
- Full Text:
- Date Issued: 1983
- Authors: Nightingale, Fiona Mary
- Date: 1983
- Subjects: Economic development projects -- South Africa --Ciskei , Job creation -- South Africa -- Ciskei , Irrigation -- South Africa -- Ciskei , Agriculture -- Economic aspects -- South Africa -- Ciskei , Black people -- Employment -- South Africa -- Ciskei
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:4862 , http://hdl.handle.net/10962/d1006912 , Economic development projects -- South Africa --Ciskei , Job creation -- South Africa -- Ciskei , Irrigation -- South Africa -- Ciskei , Agriculture -- Economic aspects -- South Africa -- Ciskei , Black people -- Employment -- South Africa -- Ciskei
- Description: Preface: "The need for development as observed today is a problem peculiar to the 20th century. The current situation is characterised by the fact that there are no more empty places on the earth, while our use of dwindling resources is curbed by environmental constraint." (Mouly and Costa, 1974, 155). The need for development is not equally felt by all nations as disparities in income and standards of living on a national basis have dissected the world into developed and underdeveloped countries. Disparities also exist within nations. These divisions are not simply determined nor are the terms related to development clearly defined - a matter that will be discussed in Chapter Two. Impetus to developing underdeveloped countries may be provided by various means, such as a general injection of capital or by more specific development projects. The purpose of these projects is to initiate changes that are intended to promote rapid development of an area. An interest has been shown by Geographers in the ability of these projects to stimulate economic growth in surrounding areas (Silberfein, 1976). The resulting success of development projects is closely related, if not determined, in large measure, by the aims. In view of the need for the aims of development projects to be successfully fulfilled, research into what constitute constructive developmental aims would be beneficial. Previous studies have revealed problems encountered with conflicting aims and objectives (Mountjoy, 1971); poorly defined aims (de Wilde, 1967); and inadequate groundwork prior to initiating the project (Berry, 1976). It is the intention of the study to examine the impact made by a development project in an underdeveloped area, and thereby assess the extent to which the development aims have been carried out. In order to carry out an examination of a development project in an underdeveloped area, an area in need of development had to be selected; a project within the area chosen for study; and the particular aim of the project examined. The Ciskei, a Homeland in South Africa, was chosen as a suitable area for study. A number of factors contribute towards it being an area in need of development, particularly as the Ciskei is a small country and dependent on South Africa, which is explained in the overview of the Ciskei in Chapter One. Three characteristics of underdevelopment noted by Seers (1972) are poverty, inequality and underemployment. Of these three factors it was decided to focus on unemployment as the indication of the extent to which development has taken place. The reduction of unemployment was one of the aims of the Keiskammahoek Irrigation Scheme, the project chosen for study. The overview concludes with a presentation of the Keiskamma Irrigation Scheme.
- Full Text:
- Date Issued: 1983
An ecological study of the ixodid tick rhipicephalus glabroscutatum (Du Toit, 1941)
- Macivor, Keith Malcolm de Falloux
- Authors: Macivor, Keith Malcolm de Falloux
- Date: 1983
- Subjects: Ticks -- Control -- South Africa -- Eastern Cape Parasites -- South Africa -- Eastern Cape Rhipicephalus -- South Africa -- Eastern Cape Angora goat -- South Africa -- Eastern Cape Larvae -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5602 , http://hdl.handle.net/10962/d1002052
- Description: An intensive study was conducted on the free-living larvae and parasitic life stages of R.glabroscutatum on Angora and Boer goats in the Uitenhage district. Free-living larvae exhibited periods of maximum relative abundance during months of generally lower rainfall, from the end of autumn to the beginning of spring. Relative larval abundance in open and gully sites was low while larvae were rarely found in bush sites. Relative abundance was higher at 20h00 than at 08h00 and 14h00. Repeated sampling in the same areas did not reduce larval numbers. Over 99% of parasitic ticks removed from Angora and Boer goats were located on the feet. The annual occurrence of a low and variable number of parasitic immatures was synchronous with the occurrence of free-living larvae. High, less variable numbers of adult ticks were removed from goat feet from September to December, the highest numbers being recorded during October and November. The occurrence of a single period of parasitic adult abundance annually indicated a life cycle with 1 generation per anum. There were higher numbers of adult ticks on the feet of the Angora goats than on the Boer goats. Adult numbers were higher on the hind feet of both breeds of goats than on the front feet. R.glabroscutatum adults seem to be implicated in the aetiology of foot abscesses since more infections were observed in Angora goats than in Boer goats and on the hind feet rather than the front feet within both goat groups. In addition R.glabroscutatum adults attached at interdigital sites where abscesses also originated and reached highest numbers in October and November when abscesses were most frequently observed. A review of distribution and host records indicated that R.glabroscutatum was limited in its distribution to the eastern Cape Province, being primarily located in South Africa's major mohair producing areas. R.glabroscutatum was classed an obligative xerophile on the basis of its recorded occurrence in non coastal areas with a low annual rainfall and Karoo and Karroid Bush vegetation. Host records for R.glabroscutatum included 10 species of wild ungulate, sheep, goats and cattle. The common site of occurrence on small stock and on small to medium sized wild animals appeared to be the legs and feet.
- Full Text:
- Date Issued: 1983
- Authors: Macivor, Keith Malcolm de Falloux
- Date: 1983
- Subjects: Ticks -- Control -- South Africa -- Eastern Cape Parasites -- South Africa -- Eastern Cape Rhipicephalus -- South Africa -- Eastern Cape Angora goat -- South Africa -- Eastern Cape Larvae -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5602 , http://hdl.handle.net/10962/d1002052
- Description: An intensive study was conducted on the free-living larvae and parasitic life stages of R.glabroscutatum on Angora and Boer goats in the Uitenhage district. Free-living larvae exhibited periods of maximum relative abundance during months of generally lower rainfall, from the end of autumn to the beginning of spring. Relative larval abundance in open and gully sites was low while larvae were rarely found in bush sites. Relative abundance was higher at 20h00 than at 08h00 and 14h00. Repeated sampling in the same areas did not reduce larval numbers. Over 99% of parasitic ticks removed from Angora and Boer goats were located on the feet. The annual occurrence of a low and variable number of parasitic immatures was synchronous with the occurrence of free-living larvae. High, less variable numbers of adult ticks were removed from goat feet from September to December, the highest numbers being recorded during October and November. The occurrence of a single period of parasitic adult abundance annually indicated a life cycle with 1 generation per anum. There were higher numbers of adult ticks on the feet of the Angora goats than on the Boer goats. Adult numbers were higher on the hind feet of both breeds of goats than on the front feet. R.glabroscutatum adults seem to be implicated in the aetiology of foot abscesses since more infections were observed in Angora goats than in Boer goats and on the hind feet rather than the front feet within both goat groups. In addition R.glabroscutatum adults attached at interdigital sites where abscesses also originated and reached highest numbers in October and November when abscesses were most frequently observed. A review of distribution and host records indicated that R.glabroscutatum was limited in its distribution to the eastern Cape Province, being primarily located in South Africa's major mohair producing areas. R.glabroscutatum was classed an obligative xerophile on the basis of its recorded occurrence in non coastal areas with a low annual rainfall and Karoo and Karroid Bush vegetation. Host records for R.glabroscutatum included 10 species of wild ungulate, sheep, goats and cattle. The common site of occurrence on small stock and on small to medium sized wild animals appeared to be the legs and feet.
- Full Text:
- Date Issued: 1983
An introduction to the Federation of South African Trade Unions
- FOSATU
- Authors: FOSATU
- Date: June 1983
- Subjects: FOSATU
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/138646 , vital:37659
- Description: The formation of FOSATU is part of a long history of struggle to organise the Black workers of South Africa into independent, non-racial trade unions. Black worker resistance in South Africa is as old as the introduction of wage labour but the first effective recorded trade union organising black workers was started in 1917 to be followed by the more famous ICU (Industrial and Commercial Workers Union) in 1919. Ever since then unions have fought against State and employer hostility to the unionisation of black workers. Other federations rose and fell. The 1950's marked a great rise in political and worker organisation with the emergence of the South African Congress of Trade Unions (SACTU) as part of the Congress Alliance. Severe State repression led to the 1960's being a low point of worker organisation. However, growing economic problems of inflation, unemployment and poverty plus a very much larger industrial working class led to an upsurge of worker militancy in the early 1970's. This gave rise to new union organisation in Natal, Transvaal and Port Elizabeth. By 1974 new coordinating bodies had emerged in Natal and the Transvaal. The need for greater unity was clear in the face of hostility from the State, employers and established unions - both the racist white unions and those in the Trade Union Council of South Africa (TUCSA).
- Full Text:
- Date Issued: June 1983
- Authors: FOSATU
- Date: June 1983
- Subjects: FOSATU
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/138646 , vital:37659
- Description: The formation of FOSATU is part of a long history of struggle to organise the Black workers of South Africa into independent, non-racial trade unions. Black worker resistance in South Africa is as old as the introduction of wage labour but the first effective recorded trade union organising black workers was started in 1917 to be followed by the more famous ICU (Industrial and Commercial Workers Union) in 1919. Ever since then unions have fought against State and employer hostility to the unionisation of black workers. Other federations rose and fell. The 1950's marked a great rise in political and worker organisation with the emergence of the South African Congress of Trade Unions (SACTU) as part of the Congress Alliance. Severe State repression led to the 1960's being a low point of worker organisation. However, growing economic problems of inflation, unemployment and poverty plus a very much larger industrial working class led to an upsurge of worker militancy in the early 1970's. This gave rise to new union organisation in Natal, Transvaal and Port Elizabeth. By 1974 new coordinating bodies had emerged in Natal and the Transvaal. The need for greater unity was clear in the face of hostility from the State, employers and established unions - both the racist white unions and those in the Trade Union Council of South Africa (TUCSA).
- Full Text:
- Date Issued: June 1983
An investigation into the problems related to the adjustment of beginning-teachers leading to the development of an induction programme
- Authors: Algie, Rowan Craig
- Date: 1983
- Subjects: Teachers, Probationary -- South Africa Teaching -- South Africa
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:1411 , http://hdl.handle.net/10962/d1003074
- Description: There is little doubt that there is a widespread concern that the transition from the supportive environment of the training institution where mistakes are expected, self criticism is encouraged and both tutorial guidance and peer group friendship are readily available into a situation where professional and personal responsibilities are profoundly altered, where the methods used, the progress of the pupils, their parents' expectations, the working relationship with colleagues are now permanent responsibilities. This transition can be traumatic for some and a considerable ordeal for many.--Chapter 1, p. 10.
- Full Text:
- Date Issued: 1983
- Authors: Algie, Rowan Craig
- Date: 1983
- Subjects: Teachers, Probationary -- South Africa Teaching -- South Africa
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:1411 , http://hdl.handle.net/10962/d1003074
- Description: There is little doubt that there is a widespread concern that the transition from the supportive environment of the training institution where mistakes are expected, self criticism is encouraged and both tutorial guidance and peer group friendship are readily available into a situation where professional and personal responsibilities are profoundly altered, where the methods used, the progress of the pupils, their parents' expectations, the working relationship with colleagues are now permanent responsibilities. This transition can be traumatic for some and a considerable ordeal for many.--Chapter 1, p. 10.
- Full Text:
- Date Issued: 1983
An investigation of the shared experience of children's literature, with particular reference to the teacher reading aloud, in senior primary classes
- Authors: McKellar, David William
- Date: 1983
- Subjects: Reading (Elementary) -- South Africa Teachers -- Training of -- South Africa Children's literature Children -- Books and reading
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:1919 , http://hdl.handle.net/10962/d1007401
- Full Text:
- Date Issued: 1983
- Authors: McKellar, David William
- Date: 1983
- Subjects: Reading (Elementary) -- South Africa Teachers -- Training of -- South Africa Children's literature Children -- Books and reading
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:1919 , http://hdl.handle.net/10962/d1007401
- Full Text:
- Date Issued: 1983
Aspects of prostacyclin in experimental hypertension
- Authors: Botha, Julia Hilary
- Date: 1983
- Subjects: Prostacyclin Prostaglandins Prostaglandin endoperoxides Thromboxanes Hypertension
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:3825 , http://hdl.handle.net/10962/d1006109
- Description: A new prostaglandin - prostaglandin X (later renamed prostacyclin or prostaglandin I₂ (PGI₂)), was discovered by Moncada, Gryglewski, Bunting and Vane in 1976. This unstable substance was shown to be produced by vascular tissue and to be a vasodilator and the most potent endogenous inhibitor of platelet aggregation known. Because of its properties, it appeared that a lack of it may be related to the development and or maintenance of hypertension, a disorder featuring vasoconstriction and an increased tendency to arterial thrombosis. The present studies aimed to investigate this possibility using a rat model. A bioassay for prostacyclin was first perfected. This consisted of a modification of the method used by Moncada, Higgs and Vane (1977): PGI₂ released by rat aortic strips, during incubation in tris buffer, was measured by assessing the ability of the incubate to inhibit adenosine diphosphate induced aggregation of human platelets, as compared to the inhibitory effect of standard prostacyclin sodium salt. The specificity of the assay for the detection of PGI₂ was tested. The abil ity of hypertensive rat aorta to release prostacycl in was investigated in two studies. The first compared aortas of Wistar rats of the New Zealand genetically hypertensive strain (GH) with those of matched normotensive Wistar controls. In the second study, hypertension was induced by wrappi ng the ri ght kidney with surgical silk and removing the contralateral kidney. Ten weeks later, aortic generation of prostacyclin by these animals was compared with that of matched sham controls which had received identical surgical manipulation but for the application of silk to the right kidney. Contrary to expectation, in both forms of hypertension, aortas of the rats with elevated pressure produced consistently more prostacyclin than those of matched controls. In order to discover more about the relationship between elevated pressure and elevated PGI₂ production, the effect of pressure reduction with hypotensive agents on the ability of GH rat aortas to produce prostacyclin, was investigated. After pressure had been controlled within normal range for one week (achieved by oral administration of furosemide, dihydralazine and reserpine for one month), aortic PGI₂ was reduced in comparison with matched GH controls. However, the reduction was not consistent and statistical significance was not reached. Because it was subsequently reported by other workers, that some of the hypotensive agents which had been employed may effect prostaglandin levels per se, no conclusions could be drawn from this study as to any possible direct relationships between pressure and aortic prostacyclin generating capacity. A further means of reducing elevated pressure (which had no inherent effect on prostaglandin levels) was thus sought. A mechanical method was eventually selected, application of a silver clip to the aortas of GH rats, just below the diaphragm, producing an immediate reduction in pressure distal to the constriction. Eighteen hours with later, PGI₂ production by these distal aortas those of matched sham GH controls and was was compared found to be consistently reduced. These results indicate that the ability to produce PGI₂ may be influenced by prior local pressure changes and that the increased capacity of hypertensive rat aortas to generate prostacyclin may be related to the increased mechanical transmural stress consequent on elevated pressure. Since haemostatic balance must be influenced not only by vascular PGI₂ generation but also by platelet sensitivity to PGI₂, the response of GH platelets to the anti-aggregatory effect of prostacyc1in was also investigated. As it had been shown by Sinzinger, Si1berbauer, Horsch and Gall (1981) that intra-arterial infusion of PGI₂ in humans decreased platelet sensitivity to the substance, the possibility existed that platelet sensitivity in hypertension might be reduced. This hypothesis was, however, invalidated as the sensitivity of GH platelets to the anti-aggregatory effect of PGI₂ was almost identical to that of normotensive controls. The shortcomings of the methodology and the possible importance of these findings in the hypertensive animal are discussed. The idea that elevated PGI₂ in hypertension may play a protective role both with respect to platelet aggregation and in attenuating further pressure rises is considered. It is finally suggested that it will be possible to draw more accurate conclusions as to the meaning of the increased PGI₂ generation in hypertension (both in relation to vascular tone and platelet function) only when details of production of, and sensitivity to, thromboxane A₂ are known. Thromboxane A₂ (TXA₂) is a vasoconstrictor and promotor of aggregation (Hamberg, Svensson and Samuelson, 1975) and it may be that, despite elevated vascular PGI₂ generation, the TXA₂/PGI₂ balance is still tipped in favour of vasoconstriction and platelet aggregation in hypertension.
- Full Text:
- Date Issued: 1983
- Authors: Botha, Julia Hilary
- Date: 1983
- Subjects: Prostacyclin Prostaglandins Prostaglandin endoperoxides Thromboxanes Hypertension
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:3825 , http://hdl.handle.net/10962/d1006109
- Description: A new prostaglandin - prostaglandin X (later renamed prostacyclin or prostaglandin I₂ (PGI₂)), was discovered by Moncada, Gryglewski, Bunting and Vane in 1976. This unstable substance was shown to be produced by vascular tissue and to be a vasodilator and the most potent endogenous inhibitor of platelet aggregation known. Because of its properties, it appeared that a lack of it may be related to the development and or maintenance of hypertension, a disorder featuring vasoconstriction and an increased tendency to arterial thrombosis. The present studies aimed to investigate this possibility using a rat model. A bioassay for prostacyclin was first perfected. This consisted of a modification of the method used by Moncada, Higgs and Vane (1977): PGI₂ released by rat aortic strips, during incubation in tris buffer, was measured by assessing the ability of the incubate to inhibit adenosine diphosphate induced aggregation of human platelets, as compared to the inhibitory effect of standard prostacyclin sodium salt. The specificity of the assay for the detection of PGI₂ was tested. The abil ity of hypertensive rat aorta to release prostacycl in was investigated in two studies. The first compared aortas of Wistar rats of the New Zealand genetically hypertensive strain (GH) with those of matched normotensive Wistar controls. In the second study, hypertension was induced by wrappi ng the ri ght kidney with surgical silk and removing the contralateral kidney. Ten weeks later, aortic generation of prostacyclin by these animals was compared with that of matched sham controls which had received identical surgical manipulation but for the application of silk to the right kidney. Contrary to expectation, in both forms of hypertension, aortas of the rats with elevated pressure produced consistently more prostacyclin than those of matched controls. In order to discover more about the relationship between elevated pressure and elevated PGI₂ production, the effect of pressure reduction with hypotensive agents on the ability of GH rat aortas to produce prostacyclin, was investigated. After pressure had been controlled within normal range for one week (achieved by oral administration of furosemide, dihydralazine and reserpine for one month), aortic PGI₂ was reduced in comparison with matched GH controls. However, the reduction was not consistent and statistical significance was not reached. Because it was subsequently reported by other workers, that some of the hypotensive agents which had been employed may effect prostaglandin levels per se, no conclusions could be drawn from this study as to any possible direct relationships between pressure and aortic prostacyclin generating capacity. A further means of reducing elevated pressure (which had no inherent effect on prostaglandin levels) was thus sought. A mechanical method was eventually selected, application of a silver clip to the aortas of GH rats, just below the diaphragm, producing an immediate reduction in pressure distal to the constriction. Eighteen hours with later, PGI₂ production by these distal aortas those of matched sham GH controls and was was compared found to be consistently reduced. These results indicate that the ability to produce PGI₂ may be influenced by prior local pressure changes and that the increased capacity of hypertensive rat aortas to generate prostacyclin may be related to the increased mechanical transmural stress consequent on elevated pressure. Since haemostatic balance must be influenced not only by vascular PGI₂ generation but also by platelet sensitivity to PGI₂, the response of GH platelets to the anti-aggregatory effect of prostacyc1in was also investigated. As it had been shown by Sinzinger, Si1berbauer, Horsch and Gall (1981) that intra-arterial infusion of PGI₂ in humans decreased platelet sensitivity to the substance, the possibility existed that platelet sensitivity in hypertension might be reduced. This hypothesis was, however, invalidated as the sensitivity of GH platelets to the anti-aggregatory effect of PGI₂ was almost identical to that of normotensive controls. The shortcomings of the methodology and the possible importance of these findings in the hypertensive animal are discussed. The idea that elevated PGI₂ in hypertension may play a protective role both with respect to platelet aggregation and in attenuating further pressure rises is considered. It is finally suggested that it will be possible to draw more accurate conclusions as to the meaning of the increased PGI₂ generation in hypertension (both in relation to vascular tone and platelet function) only when details of production of, and sensitivity to, thromboxane A₂ are known. Thromboxane A₂ (TXA₂) is a vasoconstrictor and promotor of aggregation (Hamberg, Svensson and Samuelson, 1975) and it may be that, despite elevated vascular PGI₂ generation, the TXA₂/PGI₂ balance is still tipped in favour of vasoconstriction and platelet aggregation in hypertension.
- Full Text:
- Date Issued: 1983
AZASO: tribute to women
- Authors: AZASO Western Cape Region
- Date: 1983?
- Subjects: Tamana, Dora , Anti-apartheid movements -- South Africa , Women civil rights workers -- South Africa , Anti-apartheid activists -- South Africa , South Africa -- Race relations
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/66212 , vital:28918
- Description: As women in South Africa, it is important for us to understand the nature of our oppression, for it is only after understanding it, can we identify the target of our attack and plan the appropriate strategy and tactics for our struggle. Black women in South Africa suffer three types of oppression. 1. Political oppression, which is common to all blacks in South Africa, ie. the denial of rights to vote for or choose the type of government we want, and the denial of rights as a people in South Africa. 2. Economic oppression as black workers in South Africa. Black women workers are even more exploited than men workers. They are paid lower wages for the same job, are treated as temporary staff and can be fired at anytime especially if they fall pregnant. 3. Social oppression which stems from the idea that women are born inferior to men and therefore have to play an inferior role in society. The socialization process starts at birth and women and men are geared towards certain roles in society. Men most often towards leadership positions and professional jobs and women towards household duties and secretarial jobs. This socialization process continues throughout ones life such that most people accept it as a natural phenomenon and a way of life. Having understood the forms of oppression, we can see that the struggle is not between men and women, where men are seen as the source of our oppression. Nor is it a struggle for mechanical equality between men and women ie. being paid the same wages as men, and having equal status as men in society, because this will mean equality within the present status quo. Our struggle is a struggle between womenand the existing social order. It is a struggle of the oppressed against oppression. Our main weapons in the struggle for liberation are UNITY and ORGANISATION. Unity is realised through common effort, links are forged through collective work and study, through criticism and self-critcism and through action against opression. Organization can be achieved through women's groups and organization. A women's group's first demand should be the clarification of our ideas, to get rid of miscosepts and erroneous ideas concerning the role and liberation of women. A women's group usually tackles the question of social oppresion, but more important, it must be seen as a stepping stone towards involvement in the broader struggle can we destroy the foundations of exploitative society and rebuild society on new foundations. Foundations built on the demands of the FREEDOM CHARTER. “The fundamental struggle is for national liberation of the oppressed people of South Africa, and any women's organization that stands outside this struggle must stand apart from the mass of women. What was realised by the Federation of South African Women was that it would be impossible for women to achieve their rights as women in a society in which so many fundamental rights are denied to both men and women by virtue of their colour and their class. Therefore just as there can be no revolution without the liberation of women, the struggle for women's emancipation cannot succeed without the victory of the revolution".
- Full Text:
- Date Issued: 1983?
- Authors: AZASO Western Cape Region
- Date: 1983?
- Subjects: Tamana, Dora , Anti-apartheid movements -- South Africa , Women civil rights workers -- South Africa , Anti-apartheid activists -- South Africa , South Africa -- Race relations
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/66212 , vital:28918
- Description: As women in South Africa, it is important for us to understand the nature of our oppression, for it is only after understanding it, can we identify the target of our attack and plan the appropriate strategy and tactics for our struggle. Black women in South Africa suffer three types of oppression. 1. Political oppression, which is common to all blacks in South Africa, ie. the denial of rights to vote for or choose the type of government we want, and the denial of rights as a people in South Africa. 2. Economic oppression as black workers in South Africa. Black women workers are even more exploited than men workers. They are paid lower wages for the same job, are treated as temporary staff and can be fired at anytime especially if they fall pregnant. 3. Social oppression which stems from the idea that women are born inferior to men and therefore have to play an inferior role in society. The socialization process starts at birth and women and men are geared towards certain roles in society. Men most often towards leadership positions and professional jobs and women towards household duties and secretarial jobs. This socialization process continues throughout ones life such that most people accept it as a natural phenomenon and a way of life. Having understood the forms of oppression, we can see that the struggle is not between men and women, where men are seen as the source of our oppression. Nor is it a struggle for mechanical equality between men and women ie. being paid the same wages as men, and having equal status as men in society, because this will mean equality within the present status quo. Our struggle is a struggle between womenand the existing social order. It is a struggle of the oppressed against oppression. Our main weapons in the struggle for liberation are UNITY and ORGANISATION. Unity is realised through common effort, links are forged through collective work and study, through criticism and self-critcism and through action against opression. Organization can be achieved through women's groups and organization. A women's group's first demand should be the clarification of our ideas, to get rid of miscosepts and erroneous ideas concerning the role and liberation of women. A women's group usually tackles the question of social oppresion, but more important, it must be seen as a stepping stone towards involvement in the broader struggle can we destroy the foundations of exploitative society and rebuild society on new foundations. Foundations built on the demands of the FREEDOM CHARTER. “The fundamental struggle is for national liberation of the oppressed people of South Africa, and any women's organization that stands outside this struggle must stand apart from the mass of women. What was realised by the Federation of South African Women was that it would be impossible for women to achieve their rights as women in a society in which so many fundamental rights are denied to both men and women by virtue of their colour and their class. Therefore just as there can be no revolution without the liberation of women, the struggle for women's emancipation cannot succeed without the victory of the revolution".
- Full Text:
- Date Issued: 1983?
Behavioural methods for the control of examination anxiety : an experimental investigation
- Authors: Norton, Gary Kenneth
- Date: 1983
- Subjects: Anxiety , Test anxiety
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: vital:2916 , http://hdl.handle.net/10962/d1002081
- Description: In 1982, it was reported that one in every three students who fail at South African universities, do not pass because of experiences of excessive anxiety resulting from university examinations. A survey conducted amongst student counsellors and counselling services on all South African university campuses, revealed a deficiency of group and individual therapy for this phenomenon of examination anxiety. The cause of this deficiency, was found to be the already excessive demands made on the time of student counsellors. Noting a similar situation at Rhodes University, the present investigation was initiated, with the aim of developing an economical group counselling programme for test anxious students on Rhodes campus. Sixty-four Rhodes students (who identified themselves as test anxious) volunteered for this investigation. These Subjects were randomly assigned to one of four treatment programmes (each divided into two groups, where Group A, N=6 and Group B, N=7) and a wait-list control group (N=12). Three of the treatments featured multicomponent programmes, each offering a cluster of behavioural interventions centred around: Study Skills Training/Counselling; Systematic Desensitisation (Using individually-constructed anxiety hierarchies); Systematic Desensitisation (Using group-constructed anxiety hierarchies). Included in addition, was a single-component treatment, featuring cognitive modification: a component much favoured by local test anxiety counsellors. Given adverse reports concerning the efficacy of single component programmes, when contrasted with multi component treatments, the cognitive modification package was included as a placebo. A battery of measures was used to assess test anxiety and progress made by Subjects to assuage its debilitative effects . The measures included: (a) Six Self-report measures (including a treatment evaluation schedule and the maintenance of a diary of experience by each Subject); (b) Two measures of physiological reactivity, viz. pulse rate and finger sweat print; and (c) One 'observable' measure, that of academic performance. Using these measures, an assessment of the performance gains or losses by each of the Subjects, was made on three occasions: at pre-treatment, post-treatment and 6-month follow-up. In support of the a priori hypotheses, the systematic desensitisation and study skills multicomponent programmes, realised significant gains on all measures over both the placebo and control groups (with exception of the higher score achieved by placebo subjects over that of the study skills group, on the treatment evaluation schedule) . This finding confirmed the superiority of multicomponent programmes over those with only a single component. The systematic desensitisation programmes proved to be the most effective, as measured on self-report and physiological measures. The superiority of group-constructed anxiety hierarchies over those individually-constructed was established. Study skills training helped Subjects to realise and maintain gains on the academic performance measure, although it took many of these subjects six months, before they had fully incorporated the study techniques taught, in with their own study habits. In discussion of the findings, the evident need to match test anxious students to programmes which "best suit" their characteristics, is presented, and solutions proposed. Weaknesses evident in the measuring instruments and research design, are also highlighted for discussion. As part of this experimental investigation, a discussion on the nature of test anxiety and its links with anxiety theory is introduced, together with a review of problems in measuring test anxiety; popular behavioural treatments used to relieve test anxiety; and a survey of test anxiety counselling on South African campuses. Advice for the therapist/counsellor, the academic, and the researcher, are posited in conclusion.
- Full Text:
- Date Issued: 1983
- Authors: Norton, Gary Kenneth
- Date: 1983
- Subjects: Anxiety , Test anxiety
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: vital:2916 , http://hdl.handle.net/10962/d1002081
- Description: In 1982, it was reported that one in every three students who fail at South African universities, do not pass because of experiences of excessive anxiety resulting from university examinations. A survey conducted amongst student counsellors and counselling services on all South African university campuses, revealed a deficiency of group and individual therapy for this phenomenon of examination anxiety. The cause of this deficiency, was found to be the already excessive demands made on the time of student counsellors. Noting a similar situation at Rhodes University, the present investigation was initiated, with the aim of developing an economical group counselling programme for test anxious students on Rhodes campus. Sixty-four Rhodes students (who identified themselves as test anxious) volunteered for this investigation. These Subjects were randomly assigned to one of four treatment programmes (each divided into two groups, where Group A, N=6 and Group B, N=7) and a wait-list control group (N=12). Three of the treatments featured multicomponent programmes, each offering a cluster of behavioural interventions centred around: Study Skills Training/Counselling; Systematic Desensitisation (Using individually-constructed anxiety hierarchies); Systematic Desensitisation (Using group-constructed anxiety hierarchies). Included in addition, was a single-component treatment, featuring cognitive modification: a component much favoured by local test anxiety counsellors. Given adverse reports concerning the efficacy of single component programmes, when contrasted with multi component treatments, the cognitive modification package was included as a placebo. A battery of measures was used to assess test anxiety and progress made by Subjects to assuage its debilitative effects . The measures included: (a) Six Self-report measures (including a treatment evaluation schedule and the maintenance of a diary of experience by each Subject); (b) Two measures of physiological reactivity, viz. pulse rate and finger sweat print; and (c) One 'observable' measure, that of academic performance. Using these measures, an assessment of the performance gains or losses by each of the Subjects, was made on three occasions: at pre-treatment, post-treatment and 6-month follow-up. In support of the a priori hypotheses, the systematic desensitisation and study skills multicomponent programmes, realised significant gains on all measures over both the placebo and control groups (with exception of the higher score achieved by placebo subjects over that of the study skills group, on the treatment evaluation schedule) . This finding confirmed the superiority of multicomponent programmes over those with only a single component. The systematic desensitisation programmes proved to be the most effective, as measured on self-report and physiological measures. The superiority of group-constructed anxiety hierarchies over those individually-constructed was established. Study skills training helped Subjects to realise and maintain gains on the academic performance measure, although it took many of these subjects six months, before they had fully incorporated the study techniques taught, in with their own study habits. In discussion of the findings, the evident need to match test anxious students to programmes which "best suit" their characteristics, is presented, and solutions proposed. Weaknesses evident in the measuring instruments and research design, are also highlighted for discussion. As part of this experimental investigation, a discussion on the nature of test anxiety and its links with anxiety theory is introduced, together with a review of problems in measuring test anxiety; popular behavioural treatments used to relieve test anxiety; and a survey of test anxiety counselling on South African campuses. Advice for the therapist/counsellor, the academic, and the researcher, are posited in conclusion.
- Full Text:
- Date Issued: 1983
Cognitive structuring of residential environments in black Grahamstown: a political view
- Authors: Taylor, Beverley Mary King
- Date: 1983
- Subjects: Black people -- Housing -- South Africa -- Grahamstown -- Political aspects
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:4809 , http://hdl.handle.net/10962/d1004546 , Black people -- Housing -- South Africa -- Grahamstown -- Political aspects
- Description: This research project investigates black cognitive structuring of their residential environment in the Grahamstown location. A clinical psychological method (repertory grid method) was used to elicit the construct systems of residents. The associative construct theory formulated by Kelly (1955) was used in interpreting the data set from the liberal perspective. The radical perspective demonstrated an alternative interpretation. A focus of the study centres around the possible implications of this type of research for planning action. The results showed that the repertory grid did appear to accurately reflect people's construing systems regarding their circumstances and behaviour. However, Kelly's (1955) Personal Construct Theory proved inadequate as a theory of explanation as to why people construed in the manner they did. To enhance this explanation, the marxist approach to the theory of knowledge was investigated.
- Full Text:
- Date Issued: 1983
- Authors: Taylor, Beverley Mary King
- Date: 1983
- Subjects: Black people -- Housing -- South Africa -- Grahamstown -- Political aspects
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:4809 , http://hdl.handle.net/10962/d1004546 , Black people -- Housing -- South Africa -- Grahamstown -- Political aspects
- Description: This research project investigates black cognitive structuring of their residential environment in the Grahamstown location. A clinical psychological method (repertory grid method) was used to elicit the construct systems of residents. The associative construct theory formulated by Kelly (1955) was used in interpreting the data set from the liberal perspective. The radical perspective demonstrated an alternative interpretation. A focus of the study centres around the possible implications of this type of research for planning action. The results showed that the repertory grid did appear to accurately reflect people's construing systems regarding their circumstances and behaviour. However, Kelly's (1955) Personal Construct Theory proved inadequate as a theory of explanation as to why people construed in the manner they did. To enhance this explanation, the marxist approach to the theory of knowledge was investigated.
- Full Text:
- Date Issued: 1983
Comparative bioavailability of some locally manufactured betamethasone valerate containing preparations
- Meyer, Eric, Haigh, John M, Kanfer, Isadore
- Authors: Meyer, Eric , Haigh, John M , Kanfer, Isadore
- Date: 1983
- Language: English
- Type: Article
- Identifier: vital:6399 , http://hdl.handle.net/10962/d1006326
- Description: The bioavailabilities of three locally manufactured proprietary betamethasone- 17-valerate containing creams and ointments were compared by measuring their abilities to cause blanching of human skin after topical application. The preparations studied were Betnovate Cream and Ointment, Celestoderm-V Cream and Ointment and Persivate Cream and Ointment. Celestoderm-V cream displayed a significantly superior blanching activity over both Betnovate and Persivate creams in' the occluded mode, whereas Persivate cream displayed a significantly superior blanching activity over both Betnovate and Celestoderm-V creams in the unoccluded mode. Persivate ointment was found to produce a significantly superior blanching activity over Betnovate and Celestoderm-V ointments in both the occluded and unoccluded modes of application.
- Full Text:
- Date Issued: 1983
- Authors: Meyer, Eric , Haigh, John M , Kanfer, Isadore
- Date: 1983
- Language: English
- Type: Article
- Identifier: vital:6399 , http://hdl.handle.net/10962/d1006326
- Description: The bioavailabilities of three locally manufactured proprietary betamethasone- 17-valerate containing creams and ointments were compared by measuring their abilities to cause blanching of human skin after topical application. The preparations studied were Betnovate Cream and Ointment, Celestoderm-V Cream and Ointment and Persivate Cream and Ointment. Celestoderm-V cream displayed a significantly superior blanching activity over both Betnovate and Persivate creams in' the occluded mode, whereas Persivate cream displayed a significantly superior blanching activity over both Betnovate and Celestoderm-V creams in the unoccluded mode. Persivate ointment was found to produce a significantly superior blanching activity over Betnovate and Celestoderm-V ointments in both the occluded and unoccluded modes of application.
- Full Text:
- Date Issued: 1983
Conductivity profiles for a horizontally uniform earth
- Authors: Murrell, Hugh Crozier
- Date: 1983
- Subjects: Coen, Shimon -- Criticism and interpretation Wang-Ho Yu, Michael -- Criticism and interpretation Algorithms
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5395 , http://hdl.handle.net/10962/d1001984
- Description: An investigation is made into the mathematics behind the noniterative inversion algorithm of Shimon Coen and Michael Wang-Ho Yu [1981]. The algorithm determines the conductivity profile of a horizontally uniform earth from surface measurements of apparent resistivity with a Schlumberger array. The algorithm is checked by performing the inversion on both artifical and raw field data
- Full Text:
- Date Issued: 1983
- Authors: Murrell, Hugh Crozier
- Date: 1983
- Subjects: Coen, Shimon -- Criticism and interpretation Wang-Ho Yu, Michael -- Criticism and interpretation Algorithms
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5395 , http://hdl.handle.net/10962/d1001984
- Description: An investigation is made into the mathematics behind the noniterative inversion algorithm of Shimon Coen and Michael Wang-Ho Yu [1981]. The algorithm determines the conductivity profile of a horizontally uniform earth from surface measurements of apparent resistivity with a Schlumberger array. The algorithm is checked by performing the inversion on both artifical and raw field data
- Full Text:
- Date Issued: 1983
Continuous-flow dynamic dialysis and its application to collagen-ligand interactions
- Authors: Sparrow, Neil Arthur
- Date: 1983
- Subjects: Collagen Ligands (Biochemistry) Ligand binding (Biochemistry) Protein-protein interactions Tannins
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:4297 , http://hdl.handle.net/10962/d1004617
- Description: Studies undertaken to investigate the binding of low molecular mass analogues of polyphenolic vegetable tannins to collagen have prompted the development of a new method to investigate protein-ligand interactions. This method, the continuous-flow dynamic dialysis method (CFDD), differs from conventional dialysis procedures used for protein-ligand binding studies. In this method, the ligand concentration in the diffusate is monitored automatically at successive closely spaced time intervals while being continuously eluted from the dialysis cell. The primary data obtained by this method consists of a series of spectrophotometric absorbance measurements representing the ligand concentration in the sink compartment of a dialysis cell. This primary data is recorded by means of a data logging device onto a punched paper tape for subsequent computer processing. Two original methods are presented for analysing the primary data to extract the protein-ligand binding isotherm. The first of these is a direct analysis which relies on Fick's first law of diffusion. In this method it is necessary to establish, by means of a control experiment, a value for the ligand permeation constant. This is used in a subsequent analysis to establish a relationship between the measured rate of diffusion of the ligand from a protein-ligand mixture and the concentration of unbound ligand which is in equilibrium with the protein-ligand complex. The protein-ligand binding isotherm is obtained from parametric equations which give the quantity of ligand bound to the protein and the concentration of unbound ligand in the sample compartment as functions of time. The second method, which is more general, utilizes the same primary data but is based on establishing a system transfer function to characterise the dialysis and eluting processes. This analysis depends on the linearity of the system and utilizes numerical laplace transforms of the primary data sets obtained from control and protein-ligand dialyses. Laplace transforms are used to effect a deconvolution of the transfer function from the primary data and yield the concentration of ligand in equilibrium with the protein-ligand complex. This procedure yields, simultaneously, both the total ligand concentration and the concentration of unbound ligand in the protein compartment of the dialysis cell. These quantities are used to establish the binding isotherm for the protein ligand system. Numerical inversion of the laplace transforms in this analysis is effected by their reduction to Fourier series. The experimental reliability of the continuous-flow dynamic dialysis method, and validity of the two analytical methods used to derive a binding isotherm from dialysis data are evaluated from studies of the binding of phenol red to bovine serum albumin (BSA) at 15⁰, 20⁰ and 25⁰ C, as well as from simulated binding curves generated by the numerical solution of the differential equations used to describe the dialysis and elution process in terms of a two-site Scatchard binding model. The method is used to investigate the binding to collagen of a series of low molecular mass phenolic compounds which can be isolated from Wattle and Quebracho vegetable tannin extracts. These compounds can be considered as monomeric precursor analogues of the polymeric vegetable tannins. The binding of these ligands to collagen is shown to be characterised by high capacity, low affinity binding in which the uptake of ligand by the protein increases linearly with increasing ligand concentration. Collagen exhibits no indication of site saturation for these ligands over the experimentally accessible concentration ranges investigated.
- Full Text:
- Date Issued: 1983
- Authors: Sparrow, Neil Arthur
- Date: 1983
- Subjects: Collagen Ligands (Biochemistry) Ligand binding (Biochemistry) Protein-protein interactions Tannins
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:4297 , http://hdl.handle.net/10962/d1004617
- Description: Studies undertaken to investigate the binding of low molecular mass analogues of polyphenolic vegetable tannins to collagen have prompted the development of a new method to investigate protein-ligand interactions. This method, the continuous-flow dynamic dialysis method (CFDD), differs from conventional dialysis procedures used for protein-ligand binding studies. In this method, the ligand concentration in the diffusate is monitored automatically at successive closely spaced time intervals while being continuously eluted from the dialysis cell. The primary data obtained by this method consists of a series of spectrophotometric absorbance measurements representing the ligand concentration in the sink compartment of a dialysis cell. This primary data is recorded by means of a data logging device onto a punched paper tape for subsequent computer processing. Two original methods are presented for analysing the primary data to extract the protein-ligand binding isotherm. The first of these is a direct analysis which relies on Fick's first law of diffusion. In this method it is necessary to establish, by means of a control experiment, a value for the ligand permeation constant. This is used in a subsequent analysis to establish a relationship between the measured rate of diffusion of the ligand from a protein-ligand mixture and the concentration of unbound ligand which is in equilibrium with the protein-ligand complex. The protein-ligand binding isotherm is obtained from parametric equations which give the quantity of ligand bound to the protein and the concentration of unbound ligand in the sample compartment as functions of time. The second method, which is more general, utilizes the same primary data but is based on establishing a system transfer function to characterise the dialysis and eluting processes. This analysis depends on the linearity of the system and utilizes numerical laplace transforms of the primary data sets obtained from control and protein-ligand dialyses. Laplace transforms are used to effect a deconvolution of the transfer function from the primary data and yield the concentration of ligand in equilibrium with the protein-ligand complex. This procedure yields, simultaneously, both the total ligand concentration and the concentration of unbound ligand in the protein compartment of the dialysis cell. These quantities are used to establish the binding isotherm for the protein ligand system. Numerical inversion of the laplace transforms in this analysis is effected by their reduction to Fourier series. The experimental reliability of the continuous-flow dynamic dialysis method, and validity of the two analytical methods used to derive a binding isotherm from dialysis data are evaluated from studies of the binding of phenol red to bovine serum albumin (BSA) at 15⁰, 20⁰ and 25⁰ C, as well as from simulated binding curves generated by the numerical solution of the differential equations used to describe the dialysis and elution process in terms of a two-site Scatchard binding model. The method is used to investigate the binding to collagen of a series of low molecular mass phenolic compounds which can be isolated from Wattle and Quebracho vegetable tannin extracts. These compounds can be considered as monomeric precursor analogues of the polymeric vegetable tannins. The binding of these ligands to collagen is shown to be characterised by high capacity, low affinity binding in which the uptake of ligand by the protein increases linearly with increasing ligand concentration. Collagen exhibits no indication of site saturation for these ligands over the experimentally accessible concentration ranges investigated.
- Full Text:
- Date Issued: 1983
Corporate financial reporting: history, development and future directions
- Prinsloo, K S (Keith Stephen)
- Authors: Prinsloo, K S (Keith Stephen)
- Date: 1983
- Subjects: Corporations -- Finance , Financial statements , Accounting
- Language: English
- Type: Thesis , Masters , MCom
- Identifier: vital:902 , http://hdl.handle.net/10962/d1007055 , Corporations -- Finance , Financial statements , Accounting
- Description: KMBT_363 , Adobe Acrobat 9.53 Paper Capture Plug-in
- Full Text:
- Date Issued: 1983
- Authors: Prinsloo, K S (Keith Stephen)
- Date: 1983
- Subjects: Corporations -- Finance , Financial statements , Accounting
- Language: English
- Type: Thesis , Masters , MCom
- Identifier: vital:902 , http://hdl.handle.net/10962/d1007055 , Corporations -- Finance , Financial statements , Accounting
- Description: KMBT_363 , Adobe Acrobat 9.53 Paper Capture Plug-in
- Full Text:
- Date Issued: 1983
Determination of phenylpropanolamine in serum and urine by high performance liquid chromatography
- Dowse, Roslind, Haigh, John M, Kanfer, Isadore
- Authors: Dowse, Roslind , Haigh, John M , Kanfer, Isadore
- Date: 1983
- Language: English
- Type: Article
- Identifier: vital:6361 , http://hdl.handle.net/10962/d1006056
- Description: A high-performance liquid chromatographic analysis of phenylpropanolamine in human serum and urine without prior derivatization is presented. Using direct UV detection the method is sufficiently sensitive to detect 25 ng of drug/ml of serum or urine; the coefficients of variation at 25 ng/ml and 500 ng/ml were 5.16 and 2.12, respectively, in serum. The method involves serum and urine extraction at a basic pH with chloroform, a single back-extraction, and chromatography on a reverse-phase column. Serum and urine data following administration of a single 150-mg sustained-release tablet of phenylpropanolamine hydrochloride in 6 healthy volunteers demonstrates the suitability of the analytical method.
- Full Text:
- Date Issued: 1983
- Authors: Dowse, Roslind , Haigh, John M , Kanfer, Isadore
- Date: 1983
- Language: English
- Type: Article
- Identifier: vital:6361 , http://hdl.handle.net/10962/d1006056
- Description: A high-performance liquid chromatographic analysis of phenylpropanolamine in human serum and urine without prior derivatization is presented. Using direct UV detection the method is sufficiently sensitive to detect 25 ng of drug/ml of serum or urine; the coefficients of variation at 25 ng/ml and 500 ng/ml were 5.16 and 2.12, respectively, in serum. The method involves serum and urine extraction at a basic pH with chloroform, a single back-extraction, and chromatography on a reverse-phase column. Serum and urine data following administration of a single 150-mg sustained-release tablet of phenylpropanolamine hydrochloride in 6 healthy volunteers demonstrates the suitability of the analytical method.
- Full Text:
- Date Issued: 1983
Economic geology of sulphide nickel deposits
- Authors: Harrison, P A
- Date: 1983
- Subjects: Nickel sulfide , Ore deposits , Geology, Economic , Silicate minerals , Geochemistry
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5022 , http://hdl.handle.net/10962/d1006349
- Description: From Chapter 1: It has been a long standing belief that many nickel sulphide ores are derivatives of magmatic processes in ultramafic and mafic rocks, and that they segregate from these magmas as immiscible sulphide droplets which are then concentrated into an orebody by gravitational settling either during intrusion or extrusion, or during the early stages of crystallization of the magma (Naldrett, 1981). Some geologists however, have suggested alternative mechanisms to explain the concentration of nickeliferous sulphides in the mafic and ultramafic hosts. These include hydrothermal replacement (Fleet, 1977), exhalative volcanic processes (Lusk, 1976), or major metamorphic upgrading of low grade, initially magmatic deposits (Barrett et al., 1977). It is not the purpose of this study to verify or disprove these hypotheses, but in so far as the initial concentration of sulphides in most deposits is concerned, these effects are relatively unimportant (Naldrett, 1981). The nickel sulphide ores associated with these mafic and ultramafic host rocks, invariably consist of nickeliferous pyrrhotite as the dominant phase, together with lesser, but variable, amounts of magnetite, pentlandite, chalcopyrite, cubanite, and platinum group elements (Reynolds, 1982).
- Full Text:
- Date Issued: 1983
- Authors: Harrison, P A
- Date: 1983
- Subjects: Nickel sulfide , Ore deposits , Geology, Economic , Silicate minerals , Geochemistry
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5022 , http://hdl.handle.net/10962/d1006349
- Description: From Chapter 1: It has been a long standing belief that many nickel sulphide ores are derivatives of magmatic processes in ultramafic and mafic rocks, and that they segregate from these magmas as immiscible sulphide droplets which are then concentrated into an orebody by gravitational settling either during intrusion or extrusion, or during the early stages of crystallization of the magma (Naldrett, 1981). Some geologists however, have suggested alternative mechanisms to explain the concentration of nickeliferous sulphides in the mafic and ultramafic hosts. These include hydrothermal replacement (Fleet, 1977), exhalative volcanic processes (Lusk, 1976), or major metamorphic upgrading of low grade, initially magmatic deposits (Barrett et al., 1977). It is not the purpose of this study to verify or disprove these hypotheses, but in so far as the initial concentration of sulphides in most deposits is concerned, these effects are relatively unimportant (Naldrett, 1981). The nickel sulphide ores associated with these mafic and ultramafic host rocks, invariably consist of nickeliferous pyrrhotite as the dominant phase, together with lesser, but variable, amounts of magnetite, pentlandite, chalcopyrite, cubanite, and platinum group elements (Reynolds, 1982).
- Full Text:
- Date Issued: 1983
Economic sanctions and South Africa
- Authors: Cooper, John Howard
- Date: 1983
- Subjects: Economic sanctions -- South Africa
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:1045 , http://hdl.handle.net/10962/d1006137 , Economic sanctions -- South Africa
- Description: From Introduction: There are few more emotive and contentious contemporary issues of enduring nature than the subject of economic sanctions and South Africa. The controversy surrounding this issue has implications for the structure of international social, political and economic order. The threads of the debate are woven into the historical fabric of the past two decades, during which the acrimony of arguments both for and against sanctions on South Africa has increased. Indeed, for each argument in the debate can be found a counter-argument and "lies, damned lies and statistics" abound. The complex and widespread nature of the question has elevated a practical issue into the realm of theoretical analysis. This thesis is neither purely descriptive nor purely theoretical. It has essentially two focal points, firstly, an attempt at a systematic and reasoned investigation of the many claims and counter-claims, designed to put these arguments into a broad economic framework. There is generally a greater volume of pro-sanctions literature than anti-sanctions literature, some of which is freely available in South Africa, while some is restricted and some not available at all. However, this partial lack of accessibility would seem to pose no material problem of omission: as much of the literature is repetitive, the unavailable material is usually adequately "represented" by material which is available. Also a great part of the literature contains little or no economic analysis since it focuses more on political issues. In this respect the thesis tries to represent the main points of the broad arguments concerned rather than individual nuances and personal viewpoints. It is concerned with sanctions of an economic nature rather than wider sanctions that may affect South African citizens more generally, for example, sport and diplomatic boycotts, bans and restrictions on international travel, etc.
- Full Text:
- Date Issued: 1983
- Authors: Cooper, John Howard
- Date: 1983
- Subjects: Economic sanctions -- South Africa
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:1045 , http://hdl.handle.net/10962/d1006137 , Economic sanctions -- South Africa
- Description: From Introduction: There are few more emotive and contentious contemporary issues of enduring nature than the subject of economic sanctions and South Africa. The controversy surrounding this issue has implications for the structure of international social, political and economic order. The threads of the debate are woven into the historical fabric of the past two decades, during which the acrimony of arguments both for and against sanctions on South Africa has increased. Indeed, for each argument in the debate can be found a counter-argument and "lies, damned lies and statistics" abound. The complex and widespread nature of the question has elevated a practical issue into the realm of theoretical analysis. This thesis is neither purely descriptive nor purely theoretical. It has essentially two focal points, firstly, an attempt at a systematic and reasoned investigation of the many claims and counter-claims, designed to put these arguments into a broad economic framework. There is generally a greater volume of pro-sanctions literature than anti-sanctions literature, some of which is freely available in South Africa, while some is restricted and some not available at all. However, this partial lack of accessibility would seem to pose no material problem of omission: as much of the literature is repetitive, the unavailable material is usually adequately "represented" by material which is available. Also a great part of the literature contains little or no economic analysis since it focuses more on political issues. In this respect the thesis tries to represent the main points of the broad arguments concerned rather than individual nuances and personal viewpoints. It is concerned with sanctions of an economic nature rather than wider sanctions that may affect South African citizens more generally, for example, sport and diplomatic boycotts, bans and restrictions on international travel, etc.
- Full Text:
- Date Issued: 1983
Effect of anticonvulsant agents on pineal gland indole metabolism
- Authors: Morton, Dougal John
- Date: 1983
- Subjects: Pineal gland -- Metabolism Anticonvulsants
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:3844 , http://hdl.handle.net/10962/d1009518
- Description: Preface: The general indications that the pineal gland might be involved in homeostasis, and more specifically the evidence suggesting a role in amelioration of seizure states warranted further investigation . No reports had examined a possible link between anticonvulsant drug administration and pineal gland function, and few enabled any type of presumption to be made as to possible effects. This study was an attempt to evaluate in which ways anticonvulsant drugs might alter pineal gland indole metabolism, with a view to increasing understanding of the role of the pineal in modulation of epileptic discharges. In order to make the study as meaningful as possible extensive preliminary investigations were necessary. Pharmacokinetic determinations gave an indication of tissue concentrations of the drugs, which could then be related to observed effects. As far as possible, where existing information was lacking, the catalytic behaviour of the various enzymes was characterised in order to explain any observed effects at a molecular level. An attempt was also made to characterise the regulatory mechanisms controlling indole metabolism, again in order to define the pharmacological effects exerted by the drugs used. The complexity of the system made it impossible to suggest a single uniform regulatory hypothesis, although some significant observations were made. Finally, the studies involving the anticonvulsant drugs were conducted on intact animals, isolated organs and individual enzymes in an attempt to determine whether the observed effects were occuring at a molecular, local or central level.
- Full Text:
- Date Issued: 1983
- Authors: Morton, Dougal John
- Date: 1983
- Subjects: Pineal gland -- Metabolism Anticonvulsants
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:3844 , http://hdl.handle.net/10962/d1009518
- Description: Preface: The general indications that the pineal gland might be involved in homeostasis, and more specifically the evidence suggesting a role in amelioration of seizure states warranted further investigation . No reports had examined a possible link between anticonvulsant drug administration and pineal gland function, and few enabled any type of presumption to be made as to possible effects. This study was an attempt to evaluate in which ways anticonvulsant drugs might alter pineal gland indole metabolism, with a view to increasing understanding of the role of the pineal in modulation of epileptic discharges. In order to make the study as meaningful as possible extensive preliminary investigations were necessary. Pharmacokinetic determinations gave an indication of tissue concentrations of the drugs, which could then be related to observed effects. As far as possible, where existing information was lacking, the catalytic behaviour of the various enzymes was characterised in order to explain any observed effects at a molecular level. An attempt was also made to characterise the regulatory mechanisms controlling indole metabolism, again in order to define the pharmacological effects exerted by the drugs used. The complexity of the system made it impossible to suggest a single uniform regulatory hypothesis, although some significant observations were made. Finally, the studies involving the anticonvulsant drugs were conducted on intact animals, isolated organs and individual enzymes in an attempt to determine whether the observed effects were occuring at a molecular, local or central level.
- Full Text:
- Date Issued: 1983
Evolution of the continental lithosphere: evidence from volcanics and xenoliths in southern Africa
- Hawkesworth, C J, Erlank, Anthony J, Marsh, Julian S, Menzies, M A, Van Calsteren, Peter
- Authors: Hawkesworth, C J , Erlank, Anthony J , Marsh, Julian S , Menzies, M A , Van Calsteren, Peter
- Date: 1983
- Language: English
- Type: text , conference paper
- Identifier: http://hdl.handle.net/10962/133548 , vital:36989 , https://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetailamp;idt=9641566
- Description: The geology of southern Africa offers a rare opportunity to study the evolution of a segment of continental lithosphere because its rocks range in age from 3.6 Ga to recent, and over the last 200 Ma both the upper mantle and the crust have been sampled by Karoo and Tertiary volcanism and as xenoliths in kimberlite pipes.
- Full Text:
- Date Issued: 1983
- Authors: Hawkesworth, C J , Erlank, Anthony J , Marsh, Julian S , Menzies, M A , Van Calsteren, Peter
- Date: 1983
- Language: English
- Type: text , conference paper
- Identifier: http://hdl.handle.net/10962/133548 , vital:36989 , https://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetailamp;idt=9641566
- Description: The geology of southern Africa offers a rare opportunity to study the evolution of a segment of continental lithosphere because its rocks range in age from 3.6 Ga to recent, and over the last 200 Ma both the upper mantle and the crust have been sampled by Karoo and Tertiary volcanism and as xenoliths in kimberlite pipes.
- Full Text:
- Date Issued: 1983