- Title
- Factors affecting adherence to antiretroviral therapy among pregnant women in theEastern Cape, South Africa
- Creator
- Adeola, H A
- Creator
- Adeniyi, Oladele Vincent
- Creator
- Ajayi, Anthony Idowu
- Creator
- Goon, Daniel Ter
- Creator
- Owolabi, Eyitayo Omolara
- Creator
- Eboh, Alfred
- Creator
- Lambert, John
- Date Issued
- 2018
- Date
- 2018
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/11260/5272
- Identifier
- vital:44427
- Identifier
- https://neuro.unboundmedicine.com/medline/citation/29653510/Factors_affecting_adherence_to_antiretroviral_therapy_among_pregnant_women_in_the_Eastern_Cape_South_Africa_
- Description
- Background:Context-specific factors influence adherence to antiretroviral therapy (ART) among pregnant womenliving with HIV. Gaps exist in the understanding of the reasons for the variable outcomes of the prevention ofmother-to-child transmission (PMTCT) programme at the health facility level in South Africa. This study examinedadherence levels and reasons for non-adherence during pregnancy in a cohort of parturient women enrolled in thePMTCT programme in the Eastern Cape, South Africa.Methods:This was a mixed-methods study involving 1709 parturient women in the Eastern Cape, South Africa. Weconducted a multi-centre retrospective analysis of the mother-infant pair in the PMTCT electronic database in 2016.Semi-structured interviews of purposively selected parturient women with self-reported poor adherence (n= 177)were conducted to gain understanding of the main barriers to adherence. Binary logistic regression was used todetermine the independent predictors of ART non-adherence.Results:A high proportion (69.0%) of women reported perfect adherence. In the logistic regression analysis, afteradjusting for confounding factors, marital status, cigarette smoking, alcohol use and non-disclosure to a family memberwere the independent predictors of non-adherence. Analysis of the qualitative data revealed that drug-related side-effects, being away from home, forgetfulness, non-disclosure, stigma and work-related demand were among the mainreasons for non-adherence to ART.Conclusions:Non-adherence to the antiretroviral therapy among pregnant women in this setting is associated withlifestyle behaviours, HIV-related stigma and ART side-effects. In order to eliminate mother-to-child transmission of HIV,clinicians need to screen for these factors at every antenatal clinic visit.Keywords:Adherence, Non-adherence, HIV, Antiretroviral therapy, Elimination of mother-to-child transmission,Prevention of mother-to-child transmission, Stigma, South Africa
- Format
- computer
- Format
- online resource
- Format
- Format
- 1 online resource (11 pages)
- Publisher
- PRIME PubMed
- Language
- English
- Relation
- BMC Infectious Diseases
- Relation
- Adeniyiet al. BMC Infectious Diseases (2018) 18:175 https://doi.org/10.1186/s12879-018-3087-8
- Relation
- BMC Infectious Diseases volume 18 number 1 p.175 April 2018 2078-5135
- Rights
- © Adeniyiet al. 2018
- Rights
- Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, andreproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link tothe Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.Adeniyiet al. BMC Infectious Diseases (2018) 18:175 https://doi.org/10.1186/s12879-018-3087-8
- Rights
- Open Access
- Hits: 2805
- Visitors: 2014
- Downloads: 102
Collections
Faculty of Health Sciences
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | An African perspective on the genetic risk of.pdf | 821 KB | Adobe Acrobat PDF | View Details Download |