- Title
- Hsp90 binds directly to fibronectin (FN) and inhibition reduces the extracellular fibronectin matrix in breast cancer cells:
- Creator
- Hunter, Morgan C
- Creator
- O’Hagan, Kyle L
- Creator
- Kenyon, Amy
- Creator
- Dhanani, Karim C H
- Creator
- Prinsloo, Earl
- Creator
- Edkins, Adrienne L
- Date Issued
- 2014
- Date
- 2014
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/164841
- Identifier
- vital:41177
- Identifier
- DOI: 10.1371/journal.pone.0086842
- Description
- Heat shock protein 90 (Hsp90) has been identified in the extracellular space and has been shown to chaperone a finite number of extracellular proteins involved in cell migration and invasion. We used chemical cross-linking and immunoprecipitation followed by tandem mass spectrometry (MS/MS) to isolate a complex containing Hsp90 and the matrix protein fibronectin (FN) from breast cancer cells.
- Format
- 18 pages
- Format
- Language
- English
- Relation
- PloS one
- Relation
- Hunter, M.C., O’Hagan, K.L., Kenyon, A., Dhanani, K.C., Prinsloo, E. and Edkins, A.L., 2014. Hsp90 binds directly to fibronectin (FN) and inhibition reduces the extracellular fibronectin matrix in breast cancer cells. PloS one, 9(1), p.e86842
- Relation
- PloS one volume 9 number 1 1 17 January 2014 1932-6203
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the PLOSOne Terms of Use Statement (https://www.plos.org/terms-of-use )
- Hits: 2254
- Visitors: 2398
- Downloads: 152
Collections
Thumbnail | File | Description | Size | Format | |||
---|---|---|---|---|---|---|---|
View Details Download | SOURCE1 | Hsp90 binds directly to fibronectin (FN) and inhibition reduces the extracellular fibronectin matrix in breast cancer cells.PDF | 3 MB | Adobe Acrobat PDF | View Details Download |