- Title
- Rational design and regioselective synthesis of conformationally restricted furan-derived ligands as potential anti-malarial agents
- Creator
- Mutorwa, Marius K
- Creator
- Nokalipa, Iviwe
- Creator
- Tanner, Delia C
- Creator
- Blatch, Gregory L
- Creator
- Lobb, Kevin A
- Creator
- Klein, Rosalyn
- Creator
- Kaye, Perry T
- Subject
- To be catalogued
- Date Issued
- 2020
- Date
- 2020
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/447170
- Identifier
- vital:74589
- Identifier
- xlink:href="https://doi.org/10.24820/ark.5550190.p011.281"
- Description
- Substituted 3-furanomethyl phosphate esters and their corresponding phosphoric acids have been prepared as conformationally restricted analogues of DOXP, the natural substrate for Plasmodium falciparum 1-deoxyD-xylulose-5-phosphate reductoisomerase (PfDXR), and fosmidomycin, an established inhibitor. Saturation Transfer Difference (STD) NMR analysis and in silico docking data suggest the potential of such compounds as PfDXR inhibitors.
- Format
- computer
- Format
- online resource
- Format
- application/pdf
- Format
- 1 online resource (16 pages)
- Format
- Publisher
- ARKIVOC
- Language
- English
- Relation
- Rational design and regioselective synthesis of conformationally restricted furan-derived ligands as potential anti-malarial agents
- Relation
- Mutorwa, M.K., Nokalipa, I., Tanner, D.C., Blatch, G.L., Lobb, K.A., Klein, R. and Kaye, P.T., 2020. Rational design and regioselective synthesis of conformationally restricted furan-derived ligands as potential anti-malarial agents. Organic Chemistry, (part iii), pp.0-0
- Relation
- Rational design and regioselective synthesis of conformationally restricted furan-derived ligands as potential anti-malarial agents part 3 2020 1551-7012
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the ARKIVOC Open Access Statement (https://www.arkat-usa.org/about-arkivoc/)
- Rights
- Open Access
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- Visitors: 12
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Collections
Klein, Rosalyn (Assoc Prof)
RU Centre for Chemico- and Biomedicinal Research (CCBR)
Blatch, Gregory Lloyd (Prof)
Lobb, Kevin Allan (Assoc Prof)
Kaye, Perry (Distinguished Fellow Emeritus Professor)
RU Department of Chemistry
RU Department of Biochemistry, Microbiology and Bioinformatics
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Rational design and regioselective synthesis of conformationally restricted furan-derived ligands as potential anti-malarial agents.pdf | 762 KB | Adobe Acrobat PDF | View Details Download |