Synthesis of N-Substituted phosphoramidic acid esters as “reverse” fosmidomycin analogues

Adeyemi, Christiana M; Hoppe, Heinrich C; Isaacs, Michelle; Klein, Rosalyn; Lobb, Kevin A; Kaye, Perry T

Title: Synthesis of N-Substituted phosphoramidic acid esters as “reverse” fosmidomycin analogues
Creator: Adeyemi, Christiana M
Creator: Hoppe, Heinrich C
Creator: Isaacs, Michelle
Creator: Klein, Rosalyn
Creator: Lobb, Kevin A
Creator: Kaye, Perry T
Subject: To be catalogued
Date Issued: 2019
Date: 2019
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/443238
Identifier: vital:74101
Identifier: https://doi.org/10.1016/j.tet.2019.02.003
Description: An efficient synthetic pathway to a series of novel “reverse” fosmidomycin analogues has been developed, commencing from substituted benzylamines. In these analogues, the fosmidomycin hydroxamate moiety is reversed and the tetrahedral methylene carbon adjacent to the phosphonate moiety is replaced by a nitrogen atom bearing different benzyl groups. The resulting phosphonate esters were designed as potential antimalarial “pro-drugs”.
Format: 8 pages
Format: pdf
Language: English
Relation: Tetrahedron
Relation: Adeyemi, C.M., Hoppe, H.C., Isaacs, M., Klein, R., Lobb, K.A. and Kaye, P.T., 2019. Synthesis of N-Substituted phosphoramidic acid esters as “reverse” fosmidomycin analogues. Tetrahedron, 75(16), pp.2371-2378. https://doi.org/10.1016/j.tet.2019.02.003
Relation: Tetrahedron volume 75 number 16 2371 2378 2019 0040-4020
Rights: Author
Rights: Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)

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Lobb, Kevin Allan (Assoc Prof)

Klein, Rosalyn (Assoc Prof)

Hoppe, Heinrich C (Prof)

Isaacs, Michelle (Mrs)

Kaye, Perry (Distinguished Fellow Emeritus Professor)

RU Department of Chemistry

SDG 03. Good Health and Well-Being

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