The Formation of 2, 2, 4-Trimethyl-2, 3-dihydro-1 H-1, 5-Benzodiazepine from 1, 2-Diaminobenzene in the Presence of Acetone
- Odame, Felix, Kleyi, Phumelele, Hosten, Eric C, Betz, Richard, Lobb, Kevin A, Tshentu, Zenixole R
- Authors: Odame, Felix , Kleyi, Phumelele , Hosten, Eric C , Betz, Richard , Lobb, Kevin A , Tshentu, Zenixole R
- Date: 2013
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/448952 , vital:74773 , xlink:href="https://doi.org/10.3390/molecules181114293"
- Description: In an attempt to synthesize a 2-substituted benzimidazole from the reaction of o-phenylenediamine and isophthalic acid in the presence of acetone and ethanol under microwave irradiation, a salt of the isophthalate ion and 2,2,4-trimethyl-2,3-dihydro-1H-1,5-benzodiazepin-5-ium ion was obtained. The condensation of two moles of acetone with the amine groups resulted in the formation of the benzodiazepine which crystallized as an iminium cation forming a salt with the isophthalate anion. The formation of benzodiazepine was also confirmed by performing the reaction of o-phenylenediamine with excess acetone in ethanol under conventional heating conditions. The compounds were characterized by NMR, FTIR, HRMS and microanalysis as well as X-ray crystallography. The reaction mechanism leading to the formation of benzodiazepine is also discussed.
- Full Text:
- Date Issued: 2013
- Authors: Odame, Felix , Kleyi, Phumelele , Hosten, Eric C , Betz, Richard , Lobb, Kevin A , Tshentu, Zenixole R
- Date: 2013
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/448952 , vital:74773 , xlink:href="https://doi.org/10.3390/molecules181114293"
- Description: In an attempt to synthesize a 2-substituted benzimidazole from the reaction of o-phenylenediamine and isophthalic acid in the presence of acetone and ethanol under microwave irradiation, a salt of the isophthalate ion and 2,2,4-trimethyl-2,3-dihydro-1H-1,5-benzodiazepin-5-ium ion was obtained. The condensation of two moles of acetone with the amine groups resulted in the formation of the benzodiazepine which crystallized as an iminium cation forming a salt with the isophthalate anion. The formation of benzodiazepine was also confirmed by performing the reaction of o-phenylenediamine with excess acetone in ethanol under conventional heating conditions. The compounds were characterized by NMR, FTIR, HRMS and microanalysis as well as X-ray crystallography. The reaction mechanism leading to the formation of benzodiazepine is also discussed.
- Full Text:
- Date Issued: 2013
Photodynamic inactivation of Staphylococcus aureus using low symmetrically substituted phthalocyanines supported on a polystyrene polymer fiber
- Masilela, Nkosiphile, Kleyi, Phumelele, Tshentu, Zenixole R, Priniotakis, Georgios, Westbroek, Philippe, Nyokong, Tebello
- Authors: Masilela, Nkosiphile , Kleyi, Phumelele , Tshentu, Zenixole R , Priniotakis, Georgios , Westbroek, Philippe , Nyokong, Tebello
- Language: English
- Type: Article
- Identifier: vital:7330 , http://hdl.handle.net/10962/d1020591
- Description: This work reports on the antimicrobial photo-activities of a series of low symmetrically substituted phthalocyanine complexes in solution and in a fiber matrix. Phthalocyanine complexes were successfully electrospun into a polystyrene polymer. The fiber diameter ranged from 240 nm to 390 nm in average. The modified polymer fiber showed successful singlet oxygen production with the Ge monocarboxy phthalocyanine modified fiber giving the highest singlet oxygen quantum yield value of 0.46 due to lack of aggregation when in the polymer. All the unsymmetrically substituted complexes showed antimicrobial activity towards S. Aureus under illumination with visible light. The symmetrical ZnPc and ZnTPCPc showed no activity under illumination with light in the fiber matrix due to low singlet oxygen production. , Original publication is available at http://dx.doi.org/10.1016/j.dyepig.2012.10.001
- Full Text: false
- Authors: Masilela, Nkosiphile , Kleyi, Phumelele , Tshentu, Zenixole R , Priniotakis, Georgios , Westbroek, Philippe , Nyokong, Tebello
- Language: English
- Type: Article
- Identifier: vital:7330 , http://hdl.handle.net/10962/d1020591
- Description: This work reports on the antimicrobial photo-activities of a series of low symmetrically substituted phthalocyanine complexes in solution and in a fiber matrix. Phthalocyanine complexes were successfully electrospun into a polystyrene polymer. The fiber diameter ranged from 240 nm to 390 nm in average. The modified polymer fiber showed successful singlet oxygen production with the Ge monocarboxy phthalocyanine modified fiber giving the highest singlet oxygen quantum yield value of 0.46 due to lack of aggregation when in the polymer. All the unsymmetrically substituted complexes showed antimicrobial activity towards S. Aureus under illumination with visible light. The symmetrical ZnPc and ZnTPCPc showed no activity under illumination with light in the fiber matrix due to low singlet oxygen production. , Original publication is available at http://dx.doi.org/10.1016/j.dyepig.2012.10.001
- Full Text: false
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