- Title
- Synthesis, structure and in vitro anti-trypanosomal activity of non-toxic Arylpyrrole-Based Chalcone derivatives:
- Creator
- Zulu, Ayanda I
- Creator
- Oderinlo, Ogunyemi O
- Creator
- Kruger, Cuan
- Creator
- Isaacs, Michelle
- Creator
- Hoppe, Heinrich C
- Creator
- Smith, Vincent J
- Creator
- Veale, Clinton G L
- Creator
- Khanye, Setshaba D
- Date Issued
- 2020
- Date
- 2020
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/179017
- Identifier
- vital:40096
- Identifier
- https://doi.org/10.3390/molecules25071668
- Description
- With an intention of identifying chalcone derivatives exhibiting anti-protozoal activity, a cohort of relatively unexplored arylpyrrole-based chalcone derivatives were synthesized in moderate to good yields. The resultant compounds were evaluated in vitro for their potential activity against a cultured Trypanosoma brucei brucei 427 strain. Several compounds displayed mostly modest in vitro anti-trypanosomal activity with compounds 10e and 10h emerging as active candidates with IC50 values of 4.09 and 5.11 µM, respectively. More importantly, a concomitant assessment of their activity against a human cervix adenocarcinoma (HeLa) cell line revealed that these compounds are non-toxic.
- Format
- 16 pages
- Format
- Language
- English
- Relation
- Molecules
- Relation
- Zulu, A.I., Oderinlo, O.O., Kruger, C., Isaacs, M., Hoppe, H.C., Smith, V.J., Veale, C.G. and Khanye, S.D., 2020. Synthesis, structure and in vitro anti-trypanosomal activity of non-toxic Arylpyrrole-Based Chalcone derivatives. Molecules, 25(7), p.1668
- Relation
- Molecules volume 25 number 7 p.1668 April 2020 1420-3049
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the MDPI Open Access Statement (https://www.int-res.com/journals/terms-of-use/)
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