- Title
- The in vitro antiplasmodial and antiproliferative activity of new ferrocene-based α-aminocresols targeting hemozoin inhibition and DNA interaction:
- Creator
- Mbaba, Mziyanda
- Creator
- Dingle, Laura M K
- Creator
- Swart, Tarryn
- Creator
- Cash, Devon
- Creator
- Laming, Dustin
- Creator
- de la Mare, Jo-Anne
- Creator
- Taylor, Dale
- Creator
- Hoppe, Heinrich C
- Creator
- Biot, Christophe
- Creator
- Edkins, Adrienne L
- Creator
- Khanye, Setshaba D
- Date Issued
- 2020
- Date
- 2020
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/149347
- Identifier
- vital:38827
- Identifier
- https://0-doi.org.wam.seals.ac.za/10.1002/cbic.202000132
- Description
- Compounds incorporating ferrocene in a aminocresol scaffold showed antiplasmodial and anticancer activity. SAR studies revealed that an OH group and rotatable C–NH bond are vital for biological activity, with spectrophotometric techniques and docking simulations suggesting a dual mode of action involving hemozoin inhibition and DNA interaction. Targeting multiple pathways could delay the development of clinical resistance.
- Format
- 17 pages
- Format
- Language
- English
- Relation
- ChemBioChem
- Relation
- Mbaba, M., Dingle, L.M., Swart, T., Cash, D., Laming, D., de la Mare, J.A., Taylor, D., Hoppe, H.C., Biot, C., Edkins, A.L. and Khanye, S.D., 2020. The in vitro antiplasmodial and antiproliferative activity of new ferrocene‐based α‐aminocresols targeting hemozoin inhibition and DNA interaction. ChemBioChem.
- Relation
- ChemBioChem volume number April 2020 1439-7633
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Chemistry Europe Terms of use Statement (https://0-onlinelibrary.wiley.com.wam.seals.ac.za/terms-and-conditions)
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