Electropolymerized Fluorinated Aniline-Based Fiber for Headspace Solid-Phase Microextraction and Gas Chromatographic Determination of Benzaldehyde in Injectable Pharmaceutical Formulations

Mohammadi, Ali; Mohammadi, Somayeh; Moghaddam, Bayandori A; Masoumi, Vahideh

Title: Electropolymerized Fluorinated Aniline-Based Fiber for Headspace Solid-Phase Microextraction and Gas Chromatographic Determination of Benzaldehyde in Injectable Pharmaceutical Formulations
Creator: Mohammadi, Ali
Creator: Mohammadi, Somayeh
Creator: Moghaddam, Bayandori A
Creator: Masoumi, Vahideh
Creator: Walker, Roderick B
Subject: To be catalogued
Date Issued: 2014
Date: 2014
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/184120
Identifier: vital:44175
Identifier: xlink:href="https://doi.org/10.1093/chromsci/bmt152"
Description: In this study, a simple method was developed and validated to detect trace levels of benzaldehyde in injectable pharmaceutical formulations by solid-phase microextraction coupled with gas chromatography–flame ionization detector. Polyaniline was electrodeposited on a platinum wire in trifluoroacetic acid solvent by cyclic voltammetry technique. This fiber shows high thermal and mechanical stability and high performance in extraction of benzaldehyde. Extraction and desorption time and temperature, salt effect and gas chromatography parameters were optimized as key parameters. At the optimum conditions, the fiber shows good linearity between peak area ratio of benzaldehyde/3-chlorobenzaldehyde and benzaldehyde concentration in the range of 50–800 ng/mL with percent relative standard deviation values ranging from 0.75 to 8.64% (n 5 3). The limits of quantitation and detection were 50 and 16 ng/mL, respectively. The method has the requisite selectivity, sensitivity, accuracy and precision to assay benzaldehyde in injectable pharmaceutical dosage forms.
Format: computer
Format: online resource
Format: application/pdf
Format: 1 online resource (6 pages)
Format: pdf
Publisher: Oxford University Press
Language: English
Relation: Journal of Chromatographic Science
Relation: Mohammadi, A., Mohammadi, S., Bayandori Moghaddam, A., Masoumi, V. and Walker, R.B., 2014. Electropolymerized Fluorinated Aniline-Based Fiber for Headspace Solid-Phase Microextraction and Gas Chromatographic Determination of Benzaldehyde in Injectable Pharmaceutical Formulations. Journal of chromatographic science, 52(9), pp.971-976
Relation: Journal of Chromatographic Science volume 52 number 9 p.971 2014 1945-239X
Rights: Publisher
Rights: Use of this resource is governed by the terms and conditions of the Oxford University Press https://academic.oup.com/adaptation/pages/Terms_and_Conditions
Rights: Open Access

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