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Design, synthesis and characterization of novel rhenium(V) and technetium(V) complexes as potential radiopharmaceuticals

  • Authors: Hlabela, Patrick Simon
  • Date: 2001
  • Subjects: Radiopharmaceuticals , Rhenium , Technetium
  • Language: English
  • Type: Thesis , Masters , MSc
  • Identifier: vital:4306 , http://hdl.handle.net/10962/d1004964 , Radiopharmaceuticals , Rhenium , Technetium
  • Description: A number of bidentate N, N-diethyl-N' -(R ')benzoylthiourea ligands (where R' = H,CH₃,CI,OCH₃ and N0₂) have been synthesized, as well as the three Re(V) precursor complexes, ReOCl₃(PPh₃)₂,[ReO₂(py)₄]CI and [n-Bu₄N] [ReOCI₄J. The reaction of N,N-diethyl-N'-benzoylthiourea (LH) with these three metal precursor complexes in methanol in the presence of a base gave a novel mixed-ligand complex bis(N,N-diethyl-N'-benzoylthioureato)methoxyoxorhenium(V), [ReO(L)₂(OMe)] (1). In the absence of a base and under an inert atmosphere, the reaction between [n-Bu₄N][ReOCI₄] and LH yielded bis(N,N-diethyl-N'-benzoylthioureato)chlorooxorhenium(V), [ReO(L)₂CI] (lb). The reaction of LH with [ReO₂(py)₄]CI in ethanol and iso-propanol in the presence of sodium acetate gave the novel mixed ligand complexes bis(N,N-diethyl-N'benzoylthioureato) ethoxyoxorhenium(V), [ReO(L)₂(OEt)] (6) and bis(N,N-diethyl-N'benzoylthioureato)(iso-propoxy)oxorhenium(V), [ReO(L)₂(OiPr)] (7), respectively. An oxygen bridged dirhenium complex, [(L)₂0Re-O-ReO(L)₂] (15) was obtained when the reaction was carried out in acetonitrile. A series of mixed ligand Re(V)-oxo complexes using N, N-diethyl-Nʾ-(R' )benzoylthiourea (LR'),N,N-morpholino-N' -(R')benzoylthiourea (morph-LR') and 8-(N-(R')benzoylthiocarbamoyl)-1,4-dioxa-8-azaspiro[4.5]decane ligands (spiro-LR') (where R' = H,CH₃,CI, OCH₃ and N0₂) ((1)(14) have been prepared by the reaction of [ReO₂(py)₄]CI and the ligand in the presence of sodium acetate in methanol. The solution state chemistry of these complexes has shown that complexes(1)-(14) (with the exception of (1b)) undergo dimerization in solution to give complex (15) in the presence of water. Preliminary ¹H NMR kinetics studies of the dimerization of (1), (6) and (7) to (15) have shown that the rate of dimerization decreases in the order (7) > (6) > (1). The rate of dimerization has also been compared for complexes (1), [ReO(morph-L)₂(OMe)] (8) and [ReO(spiro-L)₂(OMe)] (13) and the rate of dimerization was found to be fastest for (13). The crystal structures of (1), [ReO(LN0₂)₂(OMe)] (4), (6) and (15) have been determined. The Re(V)-oxo complexes (1), (4) and (6) have a slightly distorted octahedral geometry with the two acylthiourea ligands binding in a cis arrangement in the equatorial plane of the octahedron. The alkoxy and oxo ligands occupy the axial positions and are situated trans to each other. The crystal and molecular structure of complex (15), consist of two slightly distorted octahedral [ReO(L)₂] moieties bridged by an oxygen atom with a Re-O-Re bond angle of 175.2(2)°. The preliminary studies done in the present study have indicated that the complexation chemistry of technetium(V) with the N,N-diethyl-benzoylthiourea is different to that of rhenium (V). The reaction between [n-BuN₄][TcOCl₄] and N,N-diethyl-N'-benzoylthiourea yielded the square pyramidal cationic complex [TcO(L)₂]Cl. By contrast the octahedral methoxy complex [ReO(L )₂( OMe)] was obtained when the analogous Re(V)-oxo precursor, [n-Bu₄N] [ReOCI₄], was reacted with N,N-diethyl-N'-benzoylthiourea under the same reaction conditions.
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  • Date Issued: 2001

Design, synthesis and evaluation of silver-specific ligands

  • Authors: Daubinet, André
  • Date: 2001
  • Subjects: Ligands Ligands -- Design Ligands -- Analysis Ligands -- Evaluation Silver -- Metallurgy
  • Language: English
  • Type: Thesis , Doctoral , PhD
  • Identifier: vital:4308 , http://hdl.handle.net/10962/d1004966
  • Description: Several series of ligands, designed to chelate silver(I) specifically in the presence of base metals, have been synthesised. The ligands include: - dithiodiamide compounds, prepared by the condensation of acetanilide derivatives with 1,2-dibromoethane; propanenitrile and propanoic ester derivatives prepared from pyridine-2-carbaldehyde via the Morita-Baylis-Hillman reaction; and novel malonamide ligands from the reaction of diethyl malonate with a range of primary amines. The malonamide derivatives were prepared under both conventional thermal and microwave-assisted conditions, the latter proving to be highly efficient. The ligands were all characterised using a combination of spectroscopic and, where appropriate, elemental analysis; in one case, the structural assignment was confirmed by single-crystal X-ray analysis. The fragmentation patterns in the electron-impact mass spectra of the malonamide derivatives have been explored using high-resolution and meta-stable peak scanning techniques. Complexes of the malonamide ligands with copper(II) and silver(I) have been synthesised, and examination of these complexes has revealed distinct differences in their co-ordination preferences towards silver(I) and copper(II). Tentative, computer-modelled structures for the complexes have been proposed using the available spectroscopic and elemental analysis data. Computer modelling, at the Molecular Mechanics level, has also been used to assess the capacity of the ligand systems to adopt conformations suitable for the chelation of tetrahedral silver(I). Solvent extraction studies have been undertaken using aqueous metal ion solutions and various organic solvents. The dithiodiamide derivatives typically presented solubility problems, but one of the ligands, N,N´-bis(3-chlorophenyl)-3,6-dithiaoctanediamide, exhibited significant but slow extraction of silver(I) into toluene. The malonamide derivatives, however, proved to be readily soluble in ethyl acetate and, in some cases, exhibited good to excellent selectivity for silver(I) in the presence of the base metals copper and lead. Atomic absorption analysis revealed rapid equilibration times (<15 min) and high extraction efficiencies over a wide pH range (2.78 - 9.0). Metal selectivity has been determined by ICP-MS analysis of the residual silver, copper and lead present in the aqueous phase after 15 min, and one of the ligands, N,N´-bis(2-benzylsulfanylethyl)malonamide, exhibits excellent (≥ 96 %) silver(I) specificity.
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  • Date Issued: 2001

Determining the use of human capital to achieve a competitive advantage in the National Ports Authority of South Africa

  • Authors: Du Preez, Ian Justus
  • Date: 2001
  • Subjects: Portnet (South Africa) , Human capital -- South Africa , Personnel management -- South Africa
  • Language: English
  • Type: Thesis , Masters , MBA
  • Identifier: vital:10848 , http://hdl.handle.net/10948/50 , Portnet (South Africa) , Human capital -- South Africa , Personnel management -- South Africa
  • Description: A new business world is emerging, which every organisation must appreciate and know how to exploit. The concepts of strategy do not need to be rewritten, but must be adapted to this new era. Utilisation of the Internet and human capital to its fullest is transforming the way that business is conducted in achieving its objectives. The key to an organisation’s competitive advantage, is to invest in training, skills enhancement and the personal development of its staff. A requirement of the National Ports Authority is to be committed to basic adult education and preparing employees for re-skilling from the shop floor to the boardroom to ensure it is seen as an equal opportunity employer. The research problem addressed in this study was to determine the factors necessary to achieve strategic advantage using human capital. Relevant literature was used to develop a new model to address some of the issues facing the organisation, as well as ensuring that the National Ports Authority can leverage itself into a competitive advantage. To manage and measure knowledge-based resources is one of the most important challenges for a modern company. This challenge is incorporated in the new model developed by the study. The theoretical model consisted of various factors, which were analysed and formed into principles which were identifiable from the literature study. This model was then used to compile a questionnaire to test the responsiveness of the role players concurring. The empirical results analysed indicated that the respondents concurred with the theoretical study and factors of the new model that was developed.
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  • Date Issued: 2001

Development of effective solutions for the implementation and management of owner-driver schemes in the Province of the Eastern Cape

  • Authors: Ranchod, Sanjiv
  • Date: 2001
  • Subjects: Transportation, Automotive -- Dispatching , Small business -- Management Case studies , Storage and removal trade -- Subcontracting -- South Africa , Trucking -- South Africa , Contracting out -- South Africa
  • Language: English
  • Type: Thesis , Masters , MBA
  • Identifier: vital:10891 , http://hdl.handle.net/10948/55 , Transportation, Automotive -- Dispatching , Small business -- Management Case studies , Storage and removal trade -- Subcontracting -- South Africa , Trucking -- South Africa , Contracting out -- South Africa
  • Description: Introduction: During the past decade, companies have examined their core business, and anything that was not related to this, or did not add value to their product, was outsourced. One of the functions which fell into this category was the distribution operation, or more commonly known as transportation (in and out bound). In many instances, the distribution function was given up for tender, and specialised transport businesses, called third party logistic providers, whose core business was transport, were given the opportunity of taking over the distribution function. Some progressive companies went a little beyond the traditional approach and created opportunities for their own employees to be involved in the newly created, outsourced distribution network. This was largely an empowerment opportunity, with the aim of creating SME’s (Small-Medium-Enterprises), and providing people from a previously disadvantaged background (black people and other ethnic minorities) the opportunity to go into a business enterprise for themselves. The latter, although, politically the correct thing to do, simultaneously created opportunities and problems. Many of the companies that empowered their own employees, through Owner-Driver schemes, used the driving competency levels as the main criteria for the transition process. The other required skills were often overlooked or ignored. This empowerment process was driven to promote “Black Economic Empowerment”, an important national imperative. Although this process was an honorable gesture on the part of many companies, the process often took place without much foresight The viability and long-term continuity of the business were not taken into account. It is the researchers personal view, based on interviews with O-D’s and companies operating O-D schemes that the O-D’s which were empowered to operate their own business ventures, had limited or insufficient business skills and the very businesses that were given to them to improve their lifestyle were at risk of becoming unviable enterprises. This is clearly evident in some of the schemes being operated by companies such as Autonet and South African Breweries (hereinafter referred to as SAB). Other Eastern Cape companies that operate Owner-Driver schemes include Italtile, Shatterprufe and Ready Mix Materials (hereinafter referred to as RMM), and according to Management consultants spoken to, have obtained mixed levels of success with their schemes. The above schemes were confirmed with the various companies mentioned.
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  • Date Issued: 2001

Ecology and breeding biology of Lanner Falcons in the Eastern Cape Province, South Africa

  • Authors: Stephenson, Alan
  • Date: 2001
  • Subjects: Birds -- Breeding , Birds -- South Africa -- Eastern Cape , Birds -- Ecology , Falcons -- South Africa -- Eastern Cape
  • Language: English
  • Type: Thesis , Masters , MSc
  • Identifier: vital:5667 , http://hdl.handle.net/10962/d1005352 , Birds -- Breeding , Birds -- South Africa -- Eastern Cape , Birds -- Ecology , Falcons -- South Africa -- Eastern Cape
  • Description: Lanner Falcons Falco biarmicus are the commonest large falcons in Africa and this study in the coastal area of the Eastern Cape Province, South Africa investigated their ecology from 1984 to 2000. Lanners have recently been categorised as near-threatened and this study was initiated to ascertain if the population was stable. Breeding success of a small population, in different habitat types, was monitored intensively from 1997 to 2000, and the factors that inhibited breeding were investigated. The earliest onset of incubation was 17 July and the latest 16 August, with 2.2 young fledged per breeding pair over the four-year period. Incubation lasted 32 days and young fledged after 42-45 days. All nest sites were on cliffs with a mean height of 114 m, a mean vertical face of 53 m; 45% of the nests were in ravens’ nests. The aspect of cliff sites also influenced breeding success. Radio tracking was used to determine home range, habitat use and hunting methods, with prey species identified. Home ranges were between 66 km² and 249 km². Preferred prey was domestic chickens, pigeons and small birds during the breeding season. Foraging ranges were smaller in intensively cultivated areas with seed crops. Data obtained from ringing returns showed that no long distance movements occurred in this region, but two juveniles dispersed 152 km and 127 km. Conservation aspects with possible threats to Lanner Falcons such as poisons, electrocutions and direct persecution are discussed with some recommendations made for future research. Evidence from this study indicates that Lanner breeding success is not limited by nest site availability, but by rainfall timing and prey availability. Lanners foraged more in open areas than areas with tall vegetation, and benefited from intensive agriculture. This population appeared to be healthy and in no danger of declining in the near future.
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  • Date Issued: 2001

Economic review 2001

  • Authors: DITSELA
  • Date: 2001
  • Subjects: Development Institute for Training,Support and Education for Labour (DITSELA)
  • Language: English
  • Type: text
  • Identifier: http://hdl.handle.net/10962/178602 , vital:42958
  • Description: This volume of Bargaining Indicators for 2002 comes in the context of the September 11 attacks on the World Trade Center in New York, the United States’ war on Afghanistan, the collapse of the economy of Argentina and with it the biggest sovereign bankruptcy in history. All these historic events are unfolding within the first synchronised global recession since the 1970s, and have in turn deepened this recession. Within South Africa, this edition of Bargaining Indicators comes in the context of the first anti-government national strike by organised labour since the 1994 elections, and a deepening of the economic slowdown that we noted in the last edition of Bargaining Indicators. In this review of economic developments during 2001 we shine the spotlight on the global recession and its dynamics, and we look in particular at the slide of the world’s largest economy - that of the United States - into its first serious economic crisis since the end of the cold war, and we take a look at the significance of the attacks of September 11 and their aftermath on the dynamics of the global recession. We conclude our discussion of the global recession by discussing the responses of the Bush government and its allies, and at the meaning of these responses for neoliberal economic orthodoxy. We continue our analysis by looking at developments within the South African economy. In particular, we look at the implications of the global recession on the South African economy, and at how the currency crisis that has unfolded since the last quarter of 2001 forms an important moment in the dynamics of the unfolding global recession. Within this context we look at the main economic indicators (GDP; GDE; fixed capital formation, operating surpluses, wages, employment, savings and so on). Lastly, we look at the year ahead, and in particular at the implications of the global and domestic economic developments for the 2002 bargaining season.
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  • Date Issued: 2001

Effect of feeding regimen, temperature and stocking density on growth and survival of juvenile clownfish (Amphiprion percula)

  • Authors: Johnston, Gavin
  • Date: 2001
  • Subjects: Anemonefishes , Fishes -- Feeding and feeds , Fishes -- Growth
  • Language: English
  • Type: Thesis , Masters , MSc
  • Identifier: vital:5274 , http://hdl.handle.net/10962/d1005118 , Anemonefishes , Fishes -- Feeding and feeds , Fishes -- Growth
  • Description: In aquaculture, a thorough knowledge of the specific environmental requirements of a species is needed in order to maximize growth rate and survival. There is a paucity of data regarding the fundamental environmental requirements for the ongrowing phase of clownfish juveniles. This prompted the design of three experiments to determine the best feeding regimen, temperature and stocking density that maximize growth and survival of Amphiprion percula. Ration size and feeding frequency are important factors for optimizing fish growth during the juvenile grow-out phase. A factorial growth trial was conducted to determine the effect of feeding frequency and ration size on the growth of juvenile clownfish (Amphiprion percula).Three feeding frequencies (1, 2 and 3 times daily) and six rations (2,4,6,8, 10 and 12 % body weight per day (BW.day⁻¹)) were used to test the growth response over a twelve week period. Non-linear regression analysis on the effect of ration, independent of feeding frequency, on growth resulted in a significant (n = 36; r² = 68.7) parabolic model: In y = -0.0302x² + 0.5159x + -4.4377. Maximum growth corresponded to a ration of 8.5% BW.day⁻¹. Survival as a function of ration was significantly lower at 2% BW.day⁻¹. Data were further examined with Analysis of CoVariance (ANCOVA) to determine the effect of ration on growth at each feeding frequency. The combination revealed a maximum growth rate when the fish were fed a ration of 10% BW.day⁻¹ divided into two equal meals. The required ration per meal to maintain maximum growth was also found to decrease as feeding frequency increased. The determination of the best temperature for growth is of great importance due to the direct relationship between fish metabolism and temperature. The thermal preferendum of A. percula has already been estimated at 26 ± 0.7°C but it is not known whether this closely approximates the temperature for maximum growth. Sixteen tanks were set to different temperatures ranging between 21.5 and 30.2 °C. Ten juvenile A. percula were placed in each tank and growth was measured fortnightly over the course of the 10 week experiment. Non-linear regression analysis resulted in significant models for fish length (y = -0.0005x² + 0.00267x - 0.0338; r² = 56.7, n = 11) and weight (y= -0.00016x² + 0.0084x - 0.1073; r² = 61.6, n = 11). These models predict that maximum growth would be at 27.7 and 27.1 °C for length and weight, respectively. Temperature, over the range tested, had no apparent effect on survival. There was no significant difference between the temperatures for maximum growth and the preferred temperature. The effect of stocking densities ranging from 0.2 fish.L¹ to 4.0 fish.L⁻¹ on growth were used in the third experiment. The fish were fed to satiation twice daily and growth was measured fortnightly throughout the 8 week experiment. No effects on growth, survival or coefficient of variation were found within the range of stocking densities tested.
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  • Date Issued: 2001

Effect of high energy diets on the productive and reproductive characteristics of young Bonsmara bulls

  • Authors: Labuschagné, Hermanus Stefanus
  • Date: 2001
  • Subjects: Bonsmara cattle
  • Language: English
  • Type: Thesis , Masters , MTech (Agricultural Management)
  • Identifier: vital:10956 , http://hdl.handle.net/10948/58 , Bonsmara cattle
  • Description: A study to evaluate the effect of feeding a high energy diet on the productive and reproductive characteristics of young bulls was carried out at two different locations in the Free State Province. Two trials were conducted with the aim of evaluating the effect of level of dietary energy and age of the bulls on their productive performance and reproductive characteristics. In the first trial, two levels of energy were fed to two groups of young (343 ± days) Bonsmara bulls. The high energy group HE (n=36) bulls were Phase-C performance tested in an official performance testing center and received a high energy diet for 112 days (28 days adaptation and 84 days testing). The medium energy group ME (n=18) bulls were phase-D performance tested and received a medium-energy diet for 140 days (28 days adaptation and 112 days testing). At the end of both performance testing periods, the productive performances and reproductive characteristics of the two groups were compared. The productive parameters compared included final live body weight (FLW), average daily gain (ADG), average daily gain per day of age (ADA) and body condition score (BCS). The reproductive parameters compared between groups included scrotal circumference (SC), semen volume (Vol) and concentration (SConO), mass movement (MV), linear motility (LM), percentage live sperm (LS), as well as percentage of total abnormalities: major (MD) and minor (MinD). The results of this trial indicated that in general, bulls from the HE group showed a significant (p<0.01) higher FLW, BCS, ADG and ADA, but a significant (p<0.01) lower volume and concentration of the ejaculate, lower mass movement and linear motility, lower percentage of live sperm and higher percentage of major defects and significantly (p<0.05) higher percentage of minor defects than the bulls from the ME group. In the second trial, 36 young Bonsmara bulls were divided into two groups according to their age at the arrival at an official Phase-C performance testing center. Older bulls (OB) (n=19) and younger bulls (YB) (n=17) all received a high energy diet for 112 days (28 days adaptation and 84 days testing). At the end of the Phase-C test the productive performances and reproductive characteristics of the two groups were compared. The animals from both groups that did not pass the Phase-C test, either due to poor performance or not meeting the breed standards, were slaughtered at an official abattoir and their scrotums and carcass characteristics were also compared. The productive parameters compared between the two groups included final live body weight (FLW), average daily gain (ADG), average daily gain per day of age (ADA), body condition score (BCS), feed conversion ratio (FCR), carcass weight both warm (CWW) and cold (CWC), as well as dressing percentage (CDP) and fat grade (CFG). The reproductive parameters compared between the two groups included scrotal circumference (SC), total scrotal weight (TSW), scrotal fat (SF), scrotal skin weight (SSW), paired testes weight (PTW), scrotal skin thickness (SST), total testes circumference (TTC), total testicle volume (TTV), weight of epididimis / spermatic cord (WESC), volume of epididymis / spermatic cord (VESC) and the percentage of bulls with depressed spermatogenesis (PBDS), semen concentration (SConO), mass movement (MV), linear motility (LM), percentage live sperm (LS), percentage of total abnormalities: major (MD) and minor(MinD) as well as the percentage of bulls with depressed spermatogenesis (PBDS). The results of this trial indicated that in general, the younger bulls showed a significant (p<0.05) higher ADG, but a significant (p<0.05) lower ADA than the older bulls. Regarding the reproductive organs compared, the younger bulls showed a significantly (p<0.01) higher total scrotal weight, scrotal fat and scrotal skin weight and thickness. No significant differences were observed on the testicular parameters measured between the two groups. In addition, both weight (WECS) and volume (VECS) of the epididymis / spermatic cord were significantly (P<0.05) higher in the older bulls. In general, the younger group showed poorer semen characteristics. A significantly (p<0.01) lower sperm concentration and linear movement and a significantly (p<0.05) higher percentage of major defects were recorded on the younger bulls, when compared to the older bulls. About half of the bulls in each group showed clear signs of depressed spermatogenesis in their seminiferous tubules, during the histological examination of testicular tissue. The results of this study indicates that high energy diets are beneficial for the productive performance of young bulls (growth rate, BCS and carcass characteristics), but have a detrimental effect on the reproductive characteristics of young bulls. The effect of high energy diets on both the productive and reproductive performances of young beef bulls are more pronounced at a younger age. High energy diets resulted in heavier scrotums in the younger bulls when compared to the older bulls, as a direct result of a higher fat deposition in this region without any relevant effect on testicular size. No intra-testicular fat deposition was observed. The scrotal fat observed in high energy fed young bulls accumulated mainly in the neck of the scrotum, although subcutaneously. These fat deposits may impair testicular thermoregulation and negatively affect the spermatogenesis in the seminiferous tubules, reducing both sperm quantity and quality. Further studies on the effect of high energy diets on bull fertility (as well as on rams and buck) are recommended, to evaluate the extension and duration of its detrimental effects on subsequent fertility.
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  • Date Issued: 2001

Effect of oligomerization on the photochemical properties of silicon octaphenoxyphthalocyanine

  • Authors: Maree, M David , Nyokong, Tebello
  • Date: 2001
  • Subjects: To be catalogued
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/291542 , vital:56885 , xlink:href="https://doi.org/10.1016/S1010-6030(01)00485-3"
  • Description: The photochemical properties of silicon octaphenoxyphthalocyanines (SiOPPc) oligomerized were studied in dimethylsulfoxide (DMSO) solutions. Oligomers containing 2–5 and 9 SiOPPc rings linked with terephthalate linkages were synthesized. Singlet oxygen quantum yields were found to be in the range 0.11–0.34, and increased with the number of rings up to five rings, a decrease in the quantum yield was observed for nine rings. This is explained in terms of the high aggregation of the oligomer containing nine rings.
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  • Date Issued: 2001

Effects of discrimination on promotion of women into top managerial positions in the Eastern Cape

  • Authors: Yona, Noxolo Nondwe Trewhellah
  • Date: 2001
  • Subjects: Sex discrimination against women , Businesswomen
  • Language: English
  • Type: Thesis , Masters , MBA
  • Identifier: vital:10902 , http://hdl.handle.net/10948/57 , Sex discrimination against women , Businesswomen
  • Description: The effects of discrimination on promotion of women into top managerial positions is investigated in this study. In order to investigate these effects, the use of a questionnaire for survey was developed. The questionnaire consisted of thirty-one statements in which a response to each question contributed towards the results of this study. The literature study was used as an eye opener to the South African situation with comparison to other countries. The purpose of the empirical study was to determine the effects of discrimination especially in the Eastern Cape. The answers of the respondents were analysed and interpreted with relation to the findings from the literature study. Concluding remarks are provided which could assist firms in the private sector when faced with the challenge of the advancement of women and the implementation of the Labour policies which endorse the equal opportunity programme.
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  • Date Issued: 2001

Electrooxidation of cresols on carbon electrodes modified with phthalocyaninato and octabutoxyphthalocyaninato cobalt (II) complexes

  • Authors: Grootboom, Natasha , Nyokong, Tebello
  • Date: 2001
  • Subjects: To be catalogued
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/293207 , vital:57065 , xlink:href="https://doi.org/10.1016/S0003-2670(00)01351-9"
  • Description: Glassy carbon electrodes (GCE) modified with cobalt(II) phthalocyanine (CoPc-GCE) and cobalt(II) octabutoxyphthalocyanine (CoOBuPc-GCE) were employed for the electrochemical analysis of ortho-, meta-, and para-cresols. The oxidation potential of p-cresol was shifted towards less positive values to a larger extent, when compared to m- and o-cresols, on CoOBuPc-GCE. However, the GCE was less stable when modified with CoOBuPc than with CoPc. This is explained using the possible differences in the orientation of the adsorbed phthalocyanine molecules on the electrode. Bulk electrolysis of p-cresol at anodic potentials (1.0 V versus Ag|AgCl) on carbon electrodes modified with CoPc resulted in the formation of radicals which coupled to form trimeric products. On unmodified carbon electrodes, coupling of the radicals resulted in dimeric products following bulk electrolysis. The products formed following bulk electrolysis were characterized by liquid chromatography coupled with mass spectrometry.
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  • Date Issued: 2001

Elements of dream interpretation: laying the foundation of a basic model for clinical practice

  • Authors: Schön, Joan
  • Date: 2001
  • Subjects: Dream interpretation Dreams
  • Language: English
  • Type: Thesis , Doctoral , PhD
  • Identifier: vital:3050 , http://hdl.handle.net/10962/d1002559
  • Description: The study addresses certain paradoxes evident in the theory and practice of dream interpretation. These relate to the considerable value afforded to dreams in psychoanalytic thinking, compared with (1) the surprising dearth of literature, research, and training on dream interpretation in clinical practice, (2) the difficulties voiced by clinicians regarding dream interpretation, and (3) the diversity of keys employed by different schools to unlock the ‘truth’ of dreams. The intention of the study is to examine these paradoxes in order to develop a model fordream interpretation which falls within the ambit of psychodynamic psychotherapy. It is argued that there have been few insights over the century to match the seminal work of Freud (1900/1976), except perhaps the work of Carl Jung. As a result of the 1914 rift between these two, Jung’s insights have been largely ignored in mainstream psychoanalytic thinking and the focus on dreams has given way to other areas of development, such as, unconscious thinking, symbol formation, and interpretation in a general sense. These, it is argued, have contributed to a more comprehensive understanding of dreams and their interpretation. Thus a model would need to consider both Freud and Jung’s work, and later salient developments. It would also need to be informed by local, contemporary practice. The method used in this thesis is one of breaking down the process of dream interpretation into component parts, in order to examine useful contributions from different sources and to compare work with dreams to work with other material. The literature review examines the major theoretical contributions in relation to four elements of dreams interpretation: the nature and function of dreams, methods of dream interpretation, the meaning of dreams, and the goals of dream interpretation. A model which accommodates diverse theories without resorting to eclecticism is then proposed. Dream interpretation is further examined in the light of a multiphase clinical study, designed to provide different perspectives on the topic. The study yielded findingscompatible with the literature reviewed, as well as certain problems in relation to the proposed model. These included shortcomings of the elements used in the literature review, particularly the sequence of these elements, and caveats about affording dreams a special focus in the consulting room. Thus a second configuration was posited, namely the idea of viewing dream-work as a triangular situation, comprising the dream, the dreamer, and the dream interpreter. The final model which is the outcome of the study provides two interrelated methods of addressing dream interpretation which accommodate the theory/practice dichotomy. In the first, the elements of dreams and their interpretation are considered sequentially. This method provides a framework for considering theoretical contributions on dreams, as well as issues of technique, without recourse to the introduction of theory in the consulting room. In the second, dream interpretation is regarded as a triangular situation, comprising the interchange between therapist and patient in relation to the patient’s dream-life. This structure accommodates the alliance which is discernible in practice and draws on Segal’s (1957/1986) notion that the process of symbol formation is a triangular situation. The value of regarding ‘dream-work’ in the consulting room as a triangular situation is threefold: (1) it is akin to symbol formation in terms of the meaning reached; (2) dreams cannot be accurately interpreted in isolation from the contributions of both therapist and patient; and (3) it provides ‘dream-work’ in practice with its own structure, highlighting a perspective that dreams are an element of clinical practice, rather than a focus, a subtext within the broader framework of psychodynamic psychotherapy.
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  • Date Issued: 2001

Enhancing military efficiency : a South African perspective

  • Authors: Christie, Candice J , Todd, Andrew I
  • Date: 2001
  • Language: English
  • Type: Article
  • Identifier: vital:6749 , http://hdl.handle.net/10962/d1009329
  • Description: While extensive military research has been conducted in developed countries, very little work has been done on soldiers in industrially developing countries (IDCs). Although many aspects of marching are similar around the globe, the challenges facing soldiers in IDCs, and in particular South Africa, are unique. Since the 1990’s South Africa has seen a considerable shift in the morphological and cultural make-up of the South African National Defence Force (SANDF). The result is a mix of soldiers from a variety of ethnic backgrounds. Ethnic differences may ultimately impact performance particularly as research has postulated that Blacks and Whites may differ in body composition and body proportions. It is highly probable then that the universal recommendations of optimal marching speeds, load masses and gradients need to be modified to accommodate the diversity of soldiers which currently comprise the SANDF.
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  • Date Issued: 2001

Environment as integrating organiser: a case study of curriculum 2005 in KwaMhlanga, South Africa

  • Authors: Khumalo, Four-Ten Enock
  • Date: 2001
  • Subjects: Competency-based education -- Research -- South Africa Curriculum planning -- South Africa Environmental education -- Curricula -- South Africa -- Mpumalanga Environmental education -- Curricula
  • Language: English
  • Type: Thesis , Masters , MEd
  • Identifier: vital:1511 , http://hdl.handle.net/10962/d1003393
  • Description: Curriculum 2005 is an attempt by the South African government to create and implement a strategic plan to change the formal school curriculum. The new curriculum has 'integration' as one of its focal features. This study is an investigation of the use of' environment' as an integrating' organiser' in the senior phase of Curriculum 2005 in a selection of schools in the Mpumalanga province. While the Curriculum 2005 framework encourages curriculum integration, this is an area which might be neglected during implementation, because there is so little experience among teachers of working in an 'integrated' way. Environmental education is an approach to education which requires and facilitates curriculum integration. This study has the potential to contribute to our understanding of the integration of environmental learning across the new curriculum. Questionnaires and vignettes based on document analysis, follow-up interviews and classroom observations, involving a small group of teachers, were used in conducting the study. The investigation has revealed that participating teachers show a limited understanding of the constructs 'environment' and 'phase organiser'. Teachers do not take or introduce a critical perspective on the nature and causes of environmental issues. They treat the construct 'environment' and associated issues quite superficially when working with learners. Participating teachers generally misunderstood the concept 'phase organisers' and tended to interpret it in concepts associated with the curriculum framework they were used to. Curriculum 2005 also requires teachers to take on a more active curriculum development role. This study looked at four teachers' attempts to develop learning programme units, and at the way in which two teachers implement their curriculum plans focussing on 'environment', in the classroom. It was found that participating teachers do not always follow the same sequence or steps when developing a learning programme. Learning programme units were not considered in developmental sequence, they lacked some form of continuity and links between intended learning outcomes and teaching activities were also lacking. There was inadequate integration between learning areas. Furthermore, integration between knowledge, skills, values and attitudes was also not quite clear among the teachers, and they tended to deal with environmental knowledge in a rather limited way, focussing instead on the awareness and attitudes. These findings are of concern, and they are in keeping with the Curriculum 2005 Review Report, which highlighted the danger of inadequate focus on curriculum content. On overall teachers seem to be struggling with the whole notion of 'integration', even though environment as a phase organiser is meant to assist with curriculum integration. The thesis ends with recommendations on how teachers might be assisted to achieve meaningful curriculum integration, through using learning outcomes as well as content knowledge relevant to environmental learning.
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  • Date Issued: 2001

Enzymology of activated sewage sludge during anaerobic treatment of wastewaters : identification, characterisation, isolation and partial purification of proteases

  • Authors: Tshivhunge, Azwiedziswi Sylvia
  • Date: 2001
  • Subjects: Sewage sludge , Sewage sludge -- Environmental aspects , Sewage sludge digestion , Anaerobic bacteria
  • Language: English
  • Type: Thesis , Masters , MSc
  • Identifier: vital:4012 , http://hdl.handle.net/10962/d1004072 , Sewage sludge , Sewage sludge -- Environmental aspects , Sewage sludge digestion , Anaerobic bacteria
  • Description: During anaerobic digestion bacteria inside the digester require a carbon source for their growth and metabolism, sewage sludge was used as a carbon source in this study. The COD content was used to measure the disappearance of the substrate. COD content was reduced by 48.3% and 49% in the methanogenic and sulphidogenic bioreactors, respectively, while sulphate concentration was reduced by 40%, producing 70mg/L of hydrogen sulphide as the end product over the first 5-7 days. Sulphate (which is used as a terminal electron acceptor of sulphur reducing bacteria) has little or no effect on the sulphidogenic and methanogenic proteases. Sulphite and sulphide (the intermediate and end product of sulphate reduction) increased protease activity by 20% and 40%-80%, respectively. Maximum protease activity occurred on day 21 in the methanogenic reactor and on day 9 in the sulphidogenic reactor. The absorbance, which indicates the level of amino acid increased to 2 and 9 for methanogenic and sulphidogenic bioreactors, respectively. Proteases that were active during anaerobic digestion were associated with the pellet (organic particulate matter) of the sewage. These enzymes have an optimum activity at pH 10 and at temperature of 50°C. The proteases that were active at pH 5 and 7, had optimum temperatures at 30°C and 60°C, respectively. Due to their association with organic particulate matter, these enzymes were stable at their optimum temperatures for at least five hours at their respective pH. Inhibition by PMSF, TPCK and 1.10-phenanthroline suggested that proteases inside the anaerobic digester are a mixture of cysteine, serine and metalloproteases. At pH 5, however, EDTA appeared to enhance protease activity by 368% (three-fold). Acetic acid decreased protease activity by 21%, while both propionic and butyric acid at 200 mg/L cause total inhibition of protease activity while these acids at higher pH (where they exist as their corresponding salts) exerted little effect. Copper, iron and zinc inhibited protease activity by 85% at pH 5 with concentrations ranging between 200 and 600 mg/L. On the other hand, nickel, showed an increase in protease activity of nearly 250%. At pH 7 and 10, copper had no effect on protease activity while iron, nickel and zinc inhibited these enzymes by 20-40%. Proteases at pH 7 were extracted from the pellet by sonication, releasing 50% of the total enzymes into the solution. The enzymes were precipitated by ammonium sulphate precipitation, and further purified by ion exchange chromatography and gel filtration. Ion exchange chromatography revealed that most of the enzymes that hydrolyse proteins are negatively charged while gel filtration showed that their molecular weight is approximately 500 kDa.
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  • Date Issued: 2001

Evaluation of Lewis acid catalysed and other nitration strategies for the selective nitration of cresols

  • Authors: Van Niekerk, Rudolf Jacob Francois
  • Date: 2001
  • Subjects: Nitration
  • Language: English
  • Type: Thesis , Masters , MTech (Chemistry)
  • Identifier: vital:10957 , http://hdl.handle.net/10948/60 , Nitration
  • Description: The nitration of m- and p-cresol was investigated under mild reaction conditions in a number of solvents; the effects of certain nitration catalysts were also evaluated. These different reaction parameters were evaluated in terms of their effect on a number of important reaction responses. Other important factors that were investigated were the manipulation of the isomer ratios by changing reaction parameters, as well as important process chemistry information, such as product distribution, isolation and purification, identification of side products formed, and evaluation of the heat of reaction. Use was made of an experimental design system to evaluate the effect of reaction parameters on the chosen design responses. It was found that the ratio of para to ortho nitrocresol products could be influenced slightly by using low concentrations of nitric acid and low reaction temperatures. A different mechanism for the formation of 2-methyl-1,4-benzoquinone (from mcresol nitration) was proposed (compared with that previously reported), which could explain a “one mole nitric acid” pathway and the fact that only the pbenzoquinone isomer was observed. Reaction side products were identified and found to consist of dimers of cresol and nitrocresol, which were probably the result of oxidation of the cresol, subsequent formation of a quinomethide intermediate and reaction with either the product or the substrate. The heat of nitration was determined for various reaction systems and found to be governed by two factors, namely the actual nitration process and also an oxidation process, which is responsible for the formation of side products.
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  • Date Issued: 2001

Expanding the capabilities of the DPS lonosonde system

  • Authors: Magnus, Lindsay Gerald
  • Date: 2001
  • Subjects: Ionosondes
  • Language: English
  • Type: Thesis , Masters , MSc
  • Identifier: vital:5560 , http://hdl.handle.net/10962/d1018243
  • Description: The Digisonde Portable Sounder (DPS) is a low power pulse ionosonde capable of recording a wealth of scientific information about the ionosphere. The routine vertical incidence mode, that produces the scaled ionospheric parameters, only records limited Doppler and no precise angle of arrival (AoA) information. The drift mode produces precise scientific information but only limited range information. This thesis explains the operation of the DPS and then examines the drift data by first showing the Doppler velocities (V*) calculated for a fixed frequency ionogram as well as the velocities calculated from an interesting ionospheric disturbance measured with a stepped frequency ionogram and second by illustrating the presence of a variation in the AoA of ionospheric echoes at sunrise. The conclusion of the thesis is that a drift vertical incidence mode be developed to allow the simultaneous measurement of the scaled ionospheric parameters and the precise AoA and full Doppler spectrum information.
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  • Date Issued: 2001

Experiences in porting a virtual reality system to Java

  • Authors: Bangay, Shaun D
  • Date: 2001
  • Subjects: To be catalogued
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/433157 , vital:72947 , https://doi.org/10.1145/513867.513875
  • Description: Practical experience in porting a large virtual reality system from C/C++ to Java indicates that porting this type of real-time application is both feasible, and has several merits. The ability to transfer objects in space and time allows useful facilities such as distributed agent support and persistence to be added. Reflection and type comparisons allow flexible manipulations of objects of different types at run-time. Native calls and native code compilation reduce or remove the overhead of interpreting code.Problems encountered include difficulty in achieving cross-platform code portability, limitations of the networking libraries in Java, and clumsy coding practices forced by the language.
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  • Date Issued: 2001

Exploring job satisfaction amongst government social workers in East London

  • Authors: Sela, Michelle
  • Date: 2001
  • Subjects: Social workers -- Supervision of , Social workers -- Professional ethics , Social workers -- South Africa -- Eastern Cape -- Attitudes , Social service -- Vocational guidance
  • Language: English
  • Type: Thesis , Masters , MSocSc
  • Identifier: vital:705 , http://hdl.handle.net/10962/d1006499 , Social workers -- Supervision of , Social workers -- Professional ethics , Social workers -- South Africa -- Eastern Cape -- Attitudes , Social service -- Vocational guidance
  • Description: During this research an attempt was made to gain an understanding of job satisfaction amongst government social workers. To achieve this, twenty social workers employed at the Department of Welfare in East London and Mdantsane were interviewed. South African literature on this topic is limited and it is believed that this study will present a valuable basis to pursue in further research. Literature that was consulted was found to be supportive of the theoretical notion that social work has long been recognised as being a stressful profession and that the nature of social work practice itself can be potentially stressful. The study found that there are many stressors and dissatisfactions which government social workers are currently experiencing. Some of the social workers have indicated a desire to leave the profession as a result of the dissatisfactions. The study findings suggest a need for combining oganisational with individual oriented initiatives to decrease the many stressors the social workers are experiencing. The thesis ends with recommendations of various strategies for addressing the concerns of the social workers in order to increase their job satisfaction
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  • Date Issued: 2001

Extractives from six species of South African Marine Opisthobranch Molluscs

  • Authors: McPhail, Kerry Lee
  • Date: 2001
  • Subjects: Mollusks -- Nutrition Mollusks -- Anatomy Marine fishes -- South Africa
  • Language: English
  • Type: Thesis , Doctoral , PhD
  • Identifier: vital:4433 , http://hdl.handle.net/10962/d1007412
  • Description: The natural product chemistry of six species of South African opisthobranch molluscs and some of their dietary marine invertebrates was investigated. Nineteen previously undescribed secondary metabolites and twelve known compounds were isolated and their structures determined by a combination of spectroscopic and chemical methods. The circumtropical sea hares Aplysia parvula and A. dactylomela were found to contain halogenated red algal metabolites. 3Z-bromofucin (120), the Z analogue of a known Laurencia CIS acetogenin, was isolated from A. parvula. A. dactylomela yielded a series of novel non-aromatic cuparanes, the algoanes (121-123), the novel tricyclic Iaurane ether ibhayinol (124) and three known chamigrane sesquiterpenes, prepacifenol epoxide (101), pacif-7-enediol (104) and nidificene (125). A variety of new octocoral sesquiterpenes were isolated from the endemic South African arminacean nudibranch Leminda millecra including algoafuran (150), cubebenone (151), 8-hydroxycalamenene (152) and a series of seven triprenylated toluquinones and toluquinols (153-159). L. millecra also yielded the known sesquiterpenes millecrones A (142) and B (143) and isofuranodiene (149). Twenty eight voucher specimens and eighteen crude extracts of South African octocorals collected by the Coral Reef Research Foundation were screened by GC and GC-MS and 142 was found in Alcyonium fauri, while 143, 151 and possibly 149 were present in Leptogorgia palma. An investigation of southern African chromodorids yielded the known macrocyc1e latrunculin B (220) and two new spongiane diterpenes (221) and (222) from Chromodoris hamiltoni, while the known spongiane diterpene (210) was isolated from the endemic nudibranch Glossodoris sp. 4. The endemic nudibranch Hypselodoris capensis contained the known furanosesquiterpenes nakafuran-8 (223) and -9 (224) and the known furanosesterterpenes variabilin (195), 22-deoxyvariabilin (225) and furospinosulin (227) together with the new variant 22-deoxy-23-hydroxymethylvariabilin (226). Compounds 223 and 224 were also found in a Dysidea sponge, while the furanosesterterpenes 195, and 225-227 were present in a Fasciospongia sponge upon which H capensis specimens were found. The Dysidea dietary sponge of H capensis also yielded a new aromatic sesquiterpene, tsitsikarnmafuran (266), whose structure was confirmed by the synthesis of two possible regioisomers.
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  • Date Issued: 2001
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