Making pupils think: the development of a microcomputer-inspired adaptation of the Standard 7 mathematics curriculum
- Authors: Norman, Maxie
- Date: 1992
- Subjects: Mathematics -- Study and teaching (Secondary) -- Data processing Computer-assisted instruction
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:1667 , http://hdl.handle.net/10962/d1003550
- Description: This half-thesis gives an overview of the influence of the microcomputer on the way in which mathematics is done, taught and learnt. The nature of mathematics and the nature of the tutor, tool and tutee modes of microcomputer usage are discussed as background. A case is made for the use of action research methods and a classroom-based curriculum development model to facilitate innovation and the integration of the microcomputer into the mathematics classroom. A curriculum development cycle of situation analysis. planning, trial and evaluation is advocated. This approach is used to develop a microcomputer-based course aimed at enhancing the reasoning skills of standard 7 pupils. Pupils, working in groups of three, interact with the PROLOG system to build up databases of facts and rules. The microcomputer is used in tutee mode. In "teaching" this tutee, pupils discover the need for formal language and logical reasoning. Active learning is promoted by pupils' interaction with the PROLOG system and by discussions within groups. In this environment the teacher becomes a consultant and constructive critic rather than a lecturer. Findings suggest that the microcomputer plays an important role in terms of pupil motivation and that the microcomputer-based course enables pupils to experience formal language usage and logical reasoning·as relevant activities. Pupil databases provide evidence of the pupils' ability to make appropriate use of rules and to distinguish between and-conditions and or-conditions. The objective of making pupils think was largely achieved. It is recommended that the course be incorporated in the standard 1 or standard 8 curriculum to complement or replace parts of the Euclidean geometry sections as a vehicle for developing logical reasoning skills. Suggestions for the further use of the microcomputer as an investigative tool in mathematics classes and for further microcomputer-inspired courses are also made. The provision of appropriate training to enable teachers to make effective and innovative use of the microcomputer in mathematics lessons is advocated.
- Full Text:
- Date Issued: 1992
- Authors: Norman, Maxie
- Date: 1992
- Subjects: Mathematics -- Study and teaching (Secondary) -- Data processing Computer-assisted instruction
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:1667 , http://hdl.handle.net/10962/d1003550
- Description: This half-thesis gives an overview of the influence of the microcomputer on the way in which mathematics is done, taught and learnt. The nature of mathematics and the nature of the tutor, tool and tutee modes of microcomputer usage are discussed as background. A case is made for the use of action research methods and a classroom-based curriculum development model to facilitate innovation and the integration of the microcomputer into the mathematics classroom. A curriculum development cycle of situation analysis. planning, trial and evaluation is advocated. This approach is used to develop a microcomputer-based course aimed at enhancing the reasoning skills of standard 7 pupils. Pupils, working in groups of three, interact with the PROLOG system to build up databases of facts and rules. The microcomputer is used in tutee mode. In "teaching" this tutee, pupils discover the need for formal language and logical reasoning. Active learning is promoted by pupils' interaction with the PROLOG system and by discussions within groups. In this environment the teacher becomes a consultant and constructive critic rather than a lecturer. Findings suggest that the microcomputer plays an important role in terms of pupil motivation and that the microcomputer-based course enables pupils to experience formal language usage and logical reasoning·as relevant activities. Pupil databases provide evidence of the pupils' ability to make appropriate use of rules and to distinguish between and-conditions and or-conditions. The objective of making pupils think was largely achieved. It is recommended that the course be incorporated in the standard 1 or standard 8 curriculum to complement or replace parts of the Euclidean geometry sections as a vehicle for developing logical reasoning skills. Suggestions for the further use of the microcomputer as an investigative tool in mathematics classes and for further microcomputer-inspired courses are also made. The provision of appropriate training to enable teachers to make effective and innovative use of the microcomputer in mathematics lessons is advocated.
- Full Text:
- Date Issued: 1992
Managing historical primary and secondary sources : a study of the efficacy of a teaching handbook prepared for first-year Vista University students
- Authors: Watson, Kelvin Innes
- Date: 1992
- Subjects: History -- Study and teaching (Secondary) -- South Africa History -- Study and teaching (Higher) -- South Africa
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:1670 , http://hdl.handle.net/10962/d1003553
- Description: This study examines the teaching of primary and secondary sources in history at secondary and tertiary level. The various methods used to teach these aspects of the nature of history are compared to the Vista University teaching model. To establish the effectiveness of the vista Block A module for HIS100 students, two test instruments were devised to assess their skills in handling primary and secondary sources. Their skills in identifying relevant points from a passage of historical prose were also tested. A number of statistical techniques were applied to the data from the test instruments. This data was analysed in qualitative and quantitative terms. The results of this analysis suggested that students would probably benefit from a skills-orientated approach to studying history. On the basis of this study, it is recommended that the existing Vista teaching model be revised or amended so that a more effective method of teaching students about the nature of historical sources can be introduced.
- Full Text:
- Date Issued: 1992
- Authors: Watson, Kelvin Innes
- Date: 1992
- Subjects: History -- Study and teaching (Secondary) -- South Africa History -- Study and teaching (Higher) -- South Africa
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:1670 , http://hdl.handle.net/10962/d1003553
- Description: This study examines the teaching of primary and secondary sources in history at secondary and tertiary level. The various methods used to teach these aspects of the nature of history are compared to the Vista University teaching model. To establish the effectiveness of the vista Block A module for HIS100 students, two test instruments were devised to assess their skills in handling primary and secondary sources. Their skills in identifying relevant points from a passage of historical prose were also tested. A number of statistical techniques were applied to the data from the test instruments. This data was analysed in qualitative and quantitative terms. The results of this analysis suggested that students would probably benefit from a skills-orientated approach to studying history. On the basis of this study, it is recommended that the existing Vista teaching model be revised or amended so that a more effective method of teaching students about the nature of historical sources can be introduced.
- Full Text:
- Date Issued: 1992
Mchuyo
- Venancio Mbande and his Chopi timbila xylophone group, Tracey, Andrew T N
- Authors: Venancio Mbande and his Chopi timbila xylophone group , Tracey, Andrew T N
- Date: 1992
- Subjects: Chopi (African people) -- South Africa , Folk music , Xylophone music , Rattle (Musical instrument) , Drum (Musical instrument) , Africa South Africa Rustenburg f-sa
- Language: Chopi
- Type: sound recordings , field recordings , Sound recording material
- Identifier: http://hdl.handle.net/10962/96466 , vital:31281 , International Library of African Music, Rhodes University, Grahamstown, South Africa , ATC049b-01
- Description: Traditional dance song accompanied by timbila xylophone rattles and one drum
- Full Text: false
- Date Issued: 1992
- Authors: Venancio Mbande and his Chopi timbila xylophone group , Tracey, Andrew T N
- Date: 1992
- Subjects: Chopi (African people) -- South Africa , Folk music , Xylophone music , Rattle (Musical instrument) , Drum (Musical instrument) , Africa South Africa Rustenburg f-sa
- Language: Chopi
- Type: sound recordings , field recordings , Sound recording material
- Identifier: http://hdl.handle.net/10962/96466 , vital:31281 , International Library of African Music, Rhodes University, Grahamstown, South Africa , ATC049b-01
- Description: Traditional dance song accompanied by timbila xylophone rattles and one drum
- Full Text: false
- Date Issued: 1992
Mgeniso
- Venancio Mbande and his Chopi timbila xylophone group, Tracey, Andrew T N
- Authors: Venancio Mbande and his Chopi timbila xylophone group , Tracey, Andrew T N
- Date: 1992
- Subjects: Chopi (African people) -- South Africa , Folk music , Xylophone music , Rattle (Musical instrument) , Drum (Musical instrument) , Africa South Africa Rustenburg f-sa
- Language: Chopi
- Type: sound recordings , field recordings , Sound recording material
- Identifier: http://hdl.handle.net/10962/96448 , vital:31278 , International Library of African Music, Rhodes University, Grahamstown, South Africa , ATC049a-07
- Description: Traditional dance song accompanied by timbila xylophone rattles and one drum
- Full Text: false
- Date Issued: 1992
- Authors: Venancio Mbande and his Chopi timbila xylophone group , Tracey, Andrew T N
- Date: 1992
- Subjects: Chopi (African people) -- South Africa , Folk music , Xylophone music , Rattle (Musical instrument) , Drum (Musical instrument) , Africa South Africa Rustenburg f-sa
- Language: Chopi
- Type: sound recordings , field recordings , Sound recording material
- Identifier: http://hdl.handle.net/10962/96448 , vital:31278 , International Library of African Music, Rhodes University, Grahamstown, South Africa , ATC049a-07
- Description: Traditional dance song accompanied by timbila xylophone rattles and one drum
- Full Text: false
- Date Issued: 1992
Mtsitso 1
- Venancio Mbande and his Chopi timbila xylophone group, Tracey, Andrew T N
- Authors: Venancio Mbande and his Chopi timbila xylophone group , Tracey, Andrew T N
- Date: 1992
- Subjects: Chopi (African people) -- South Africa , Folk music , Xylophone music , Rattle (Musical instrument) , Drum (Musical instrument) , Africa South Africa Rustenburg f-sa
- Language: Chopi
- Type: sound recordings , field recordings , Sound recording material
- Identifier: http://hdl.handle.net/10962/96402 , vital:31272 , International Library of African Music, Rhodes University, Grahamstown, South Africa , ATC049a-01
- Description: Traditional dance song accompanied by timbila xylophone rattles and one drum
- Full Text: false
- Date Issued: 1992
- Authors: Venancio Mbande and his Chopi timbila xylophone group , Tracey, Andrew T N
- Date: 1992
- Subjects: Chopi (African people) -- South Africa , Folk music , Xylophone music , Rattle (Musical instrument) , Drum (Musical instrument) , Africa South Africa Rustenburg f-sa
- Language: Chopi
- Type: sound recordings , field recordings , Sound recording material
- Identifier: http://hdl.handle.net/10962/96402 , vital:31272 , International Library of African Music, Rhodes University, Grahamstown, South Africa , ATC049a-01
- Description: Traditional dance song accompanied by timbila xylophone rattles and one drum
- Full Text: false
- Date Issued: 1992
Mtsitso 2
- Venancio Mbande and his Chopi timbila xylophone group, Tracey, Andrew T N
- Authors: Venancio Mbande and his Chopi timbila xylophone group , Tracey, Andrew T N
- Date: 1992
- Subjects: Chopi (African people) -- South Africa , Folk music , Xylophone music , Rattle (Musical instrument) , Drum (Musical instrument) , Africa South Africa Rustenburg f-sa
- Language: Chopi
- Type: sound recordings , field recordings , Sound recording material
- Identifier: http://hdl.handle.net/10962/96407 , vital:31273 , International Library of African Music, Rhodes University, Grahamstown, South Africa , ATC049a-02
- Description: Traditional dance song accompanied by timbila xylophone rattles and one drum
- Full Text: false
- Date Issued: 1992
- Authors: Venancio Mbande and his Chopi timbila xylophone group , Tracey, Andrew T N
- Date: 1992
- Subjects: Chopi (African people) -- South Africa , Folk music , Xylophone music , Rattle (Musical instrument) , Drum (Musical instrument) , Africa South Africa Rustenburg f-sa
- Language: Chopi
- Type: sound recordings , field recordings , Sound recording material
- Identifier: http://hdl.handle.net/10962/96407 , vital:31273 , International Library of African Music, Rhodes University, Grahamstown, South Africa , ATC049a-02
- Description: Traditional dance song accompanied by timbila xylophone rattles and one drum
- Full Text: false
- Date Issued: 1992
Mtsitso 3
- Venancio Mbande and his Chopi timbila xylophone group, Tracey, Andrew T N
- Authors: Venancio Mbande and his Chopi timbila xylophone group , Tracey, Andrew T N
- Date: 1992
- Subjects: Chopi (African people) -- South Africa , Folk music , Xylophone music , Rattle (Musical instrument) , Drum (Musical instrument) , Africa South Africa Rustenburg f-sa
- Language: Chopi
- Type: sound recordings , field recordings , Sound recording material
- Identifier: http://hdl.handle.net/10962/96421 , vital:31274 , International Library of African Music, Rhodes University, Grahamstown, South Africa , ATC049a-03
- Description: Traditional dance song accompanied by timbila xylophone rattles and one drum
- Full Text: false
- Date Issued: 1992
- Authors: Venancio Mbande and his Chopi timbila xylophone group , Tracey, Andrew T N
- Date: 1992
- Subjects: Chopi (African people) -- South Africa , Folk music , Xylophone music , Rattle (Musical instrument) , Drum (Musical instrument) , Africa South Africa Rustenburg f-sa
- Language: Chopi
- Type: sound recordings , field recordings , Sound recording material
- Identifier: http://hdl.handle.net/10962/96421 , vital:31274 , International Library of African Music, Rhodes University, Grahamstown, South Africa , ATC049a-03
- Description: Traditional dance song accompanied by timbila xylophone rattles and one drum
- Full Text: false
- Date Issued: 1992
Mtsitso 4
- Venancio Mbande and his Chopi timbila xylophone group, Tracey, Andrew T N
- Authors: Venancio Mbande and his Chopi timbila xylophone group , Tracey, Andrew T N
- Date: 1992
- Subjects: Chopi (African people) -- South Africa , Folk music , Xylophone music , Rattle (Musical instrument) , Drum (Musical instrument) , Africa South Africa Rustenburg f-sa
- Language: Chopi
- Type: sound recordings , field recordings , Sound recording material
- Identifier: http://hdl.handle.net/10962/96426 , vital:31275 , International Library of African Music, Rhodes University, Grahamstown, South Africa , ATC049a-04
- Description: Traditional dance song accompanied by timbila xylophone rattles and one drum
- Full Text: false
- Date Issued: 1992
- Authors: Venancio Mbande and his Chopi timbila xylophone group , Tracey, Andrew T N
- Date: 1992
- Subjects: Chopi (African people) -- South Africa , Folk music , Xylophone music , Rattle (Musical instrument) , Drum (Musical instrument) , Africa South Africa Rustenburg f-sa
- Language: Chopi
- Type: sound recordings , field recordings , Sound recording material
- Identifier: http://hdl.handle.net/10962/96426 , vital:31275 , International Library of African Music, Rhodes University, Grahamstown, South Africa , ATC049a-04
- Description: Traditional dance song accompanied by timbila xylophone rattles and one drum
- Full Text: false
- Date Issued: 1992
Mtsitso 5
- Venancio Mbande and his Chopi timbila xylophone group, Tracey, Andrew T N
- Authors: Venancio Mbande and his Chopi timbila xylophone group , Tracey, Andrew T N
- Date: 1992
- Subjects: Chopi (African people) -- South Africa , Folk music , Xylophone music , Rattle (Musical instrument) , Drum (Musical instrument) , Africa South Africa Rustenburg f-sa
- Language: Chopi
- Type: sound recordings , field recordings , Sound recording material
- Identifier: http://hdl.handle.net/10962/96439 , vital:31276 , International Library of African Music, Rhodes University, Grahamstown, South Africa , ATC049a-05
- Description: Traditional dance song accompanied by timbila xylophone rattles and one drum
- Full Text: false
- Date Issued: 1992
- Authors: Venancio Mbande and his Chopi timbila xylophone group , Tracey, Andrew T N
- Date: 1992
- Subjects: Chopi (African people) -- South Africa , Folk music , Xylophone music , Rattle (Musical instrument) , Drum (Musical instrument) , Africa South Africa Rustenburg f-sa
- Language: Chopi
- Type: sound recordings , field recordings , Sound recording material
- Identifier: http://hdl.handle.net/10962/96439 , vital:31276 , International Library of African Music, Rhodes University, Grahamstown, South Africa , ATC049a-05
- Description: Traditional dance song accompanied by timbila xylophone rattles and one drum
- Full Text: false
- Date Issued: 1992
Mtsitso 6
- Venancio Mbande and his Chopi timbila xylophone group, Tracey, Andrew T N
- Authors: Venancio Mbande and his Chopi timbila xylophone group , Tracey, Andrew T N
- Date: 1992
- Subjects: Chopi (African people) -- South Africa , Folk music , Xylophone music , Rattle (Musical instrument) , Drum (Musical instrument) , Africa South Africa Rustenburg f-sa
- Language: Chopi
- Type: sound recordings , field recordings , Sound recording material
- Identifier: http://hdl.handle.net/10962/96444 , vital:31277 , International Library of African Music, Rhodes University, Grahamstown, South Africa , ATC049a-06
- Description: Traditional dance song accompanied by timbila xylophone rattles and one drum
- Full Text: false
- Date Issued: 1992
- Authors: Venancio Mbande and his Chopi timbila xylophone group , Tracey, Andrew T N
- Date: 1992
- Subjects: Chopi (African people) -- South Africa , Folk music , Xylophone music , Rattle (Musical instrument) , Drum (Musical instrument) , Africa South Africa Rustenburg f-sa
- Language: Chopi
- Type: sound recordings , field recordings , Sound recording material
- Identifier: http://hdl.handle.net/10962/96444 , vital:31277 , International Library of African Music, Rhodes University, Grahamstown, South Africa , ATC049a-06
- Description: Traditional dance song accompanied by timbila xylophone rattles and one drum
- Full Text: false
- Date Issued: 1992
Mzeno
- Venancio Mbande and his Chopi timbila xylophone group, Tracey, Andrew T N
- Authors: Venancio Mbande and his Chopi timbila xylophone group , Tracey, Andrew T N
- Date: 1992
- Subjects: Chopi (African people) -- South Africa , Folk music , Xylophone music , Rattle (Musical instrument) , Drum (Musical instrument) , Africa South Africa Rustenburg f-sa
- Language: Chopi
- Type: sound recordings , field recordings , Sound recording material
- Identifier: http://hdl.handle.net/10962/96489 , vital:31285 , International Library of African Music, Rhodes University, Grahamstown, South Africa , ATC049b-03
- Description: Traditional dance song accompanied by timbila xylophone rattles and one drum
- Full Text: false
- Date Issued: 1992
- Authors: Venancio Mbande and his Chopi timbila xylophone group , Tracey, Andrew T N
- Date: 1992
- Subjects: Chopi (African people) -- South Africa , Folk music , Xylophone music , Rattle (Musical instrument) , Drum (Musical instrument) , Africa South Africa Rustenburg f-sa
- Language: Chopi
- Type: sound recordings , field recordings , Sound recording material
- Identifier: http://hdl.handle.net/10962/96489 , vital:31285 , International Library of African Music, Rhodes University, Grahamstown, South Africa , ATC049b-03
- Description: Traditional dance song accompanied by timbila xylophone rattles and one drum
- Full Text: false
- Date Issued: 1992
Namibia's long road to independence : the Botha era
- Authors: Ruiters, Michele René
- Date: 1992
- Subjects: United Nations -- Namibia , Namibia -- History -- 1946-1990 , Namibia -- Politics and government -- 1946-1990
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: vital:2754 , http://hdl.handle.net/10962/d1002001
- Description: This thesis deals with the ten years preceding Namibia's independence in March 1990. It examines the various characters and groups in this process, and how their roles delayed or promoted it. The era of Pieter W. Botha is very significant in that his rule brought many changes to the decision-making process and content of South African foreign policy. This period, 1978 - 1989, marked the formulation of the Total National Strategy in response to the Total Onslaught being waged on South Africa by perceived hostile external forces. Namibia's transition to independence suffered under this military-oriented policy as did the rest of the region. Never before in South Africa's policy-making history had the security sector played such a major role. Regional relations changed subsequent to the policy changes because of the distorted vision the Botha regime had of black-ruled states. Namibia was seen as an important pawn in the Total National Strategy as the last buffer state in Southern Africa protecting South Africa's white minority regime
- Full Text:
- Date Issued: 1992
- Authors: Ruiters, Michele René
- Date: 1992
- Subjects: United Nations -- Namibia , Namibia -- History -- 1946-1990 , Namibia -- Politics and government -- 1946-1990
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: vital:2754 , http://hdl.handle.net/10962/d1002001
- Description: This thesis deals with the ten years preceding Namibia's independence in March 1990. It examines the various characters and groups in this process, and how their roles delayed or promoted it. The era of Pieter W. Botha is very significant in that his rule brought many changes to the decision-making process and content of South African foreign policy. This period, 1978 - 1989, marked the formulation of the Total National Strategy in response to the Total Onslaught being waged on South Africa by perceived hostile external forces. Namibia's transition to independence suffered under this military-oriented policy as did the rest of the region. Never before in South Africa's policy-making history had the security sector played such a major role. Regional relations changed subsequent to the policy changes because of the distorted vision the Botha regime had of black-ruled states. Namibia was seen as an important pawn in the Total National Strategy as the last buffer state in Southern Africa protecting South Africa's white minority regime
- Full Text:
- Date Issued: 1992
Neotype description for the African catfish Clarias Gariepinus (Burchell, 1822) (Pisces: Siluroidei: Clariidae)
- Skelton, Paul H (Paul Harvey), Teugels, Guy G
- Authors: Skelton, Paul H (Paul Harvey) , Teugels, Guy G
- Date: 1992
- Subjects: Catfishes -- Africa , Clariidae -- Africa
- Language: English
- Type: Text
- Identifier: vital:14995 , http://hdl.handle.net/10962/d1019675 , ISBN 0-86810-231-8 , Ichthyological Bulletin of the J.L.B. Smith Institute of Ichthyology; No. 56
- Description: A neotype for Clarias gariepinus (Burchell, 1822) is designated and described. Data from 41 specimens from the type locality are also presented. The geographical distribution of the species is discussed. , Rhodes University Libraries (Digitisation)
- Full Text:
- Date Issued: 1992
- Authors: Skelton, Paul H (Paul Harvey) , Teugels, Guy G
- Date: 1992
- Subjects: Catfishes -- Africa , Clariidae -- Africa
- Language: English
- Type: Text
- Identifier: vital:14995 , http://hdl.handle.net/10962/d1019675 , ISBN 0-86810-231-8 , Ichthyological Bulletin of the J.L.B. Smith Institute of Ichthyology; No. 56
- Description: A neotype for Clarias gariepinus (Burchell, 1822) is designated and described. Data from 41 specimens from the type locality are also presented. The geographical distribution of the species is discussed. , Rhodes University Libraries (Digitisation)
- Full Text:
- Date Issued: 1992
Neuropharmacological interactions in the rat pineal gland a study of antidepressant drugs
- Authors: Banoo, Shabir
- Date: 1992
- Subjects: Antidepressants -- Research , Pineal gland -- Research
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:3744 , http://hdl.handle.net/10962/d1003222 , Antidepressants -- Research , Pineal gland -- Research
- Description: The rat pineal gland provides a convenient model for investigating nor adrenergic receptor neurotransmission and the effects of various drugs on these processes in health and disease. The effect of a variety of antidepressant drugs on rat pineal gland function following acute and chronic administration is described. Antidepressants from several different classes increase melatonin synthesis in rat pineal gland cultures when administered acutely. This effect appears to be mediated by noradrenaline acting on postsynaptic β-adrenoceptors. Activation of these receptors, in turn, activates the enzyme serotonin N-acetyltransferase via a cyclic adenosine monophosphate (cAMP) second messenger system. Serotonin N-acetyltransferase catalyses the rate-limiting conversion of serotonin to melatonin. Blockade of postsynaptic β-adrenoceptors prevents the antidepressant-induced increase in melatonin synthesis. The possibility that atypical antidepressants as well as those that selectively inhibit serotonin reuptake may increase melatonin synthesis via a β-adrenoceptor mechanism is discussed. In contrast, however, antidepressants from different classes have variable effects on rat pineal gland function when administered repeatedly. Chronic treatment with antidepressants that selectively inhibit noradrenaline reuptake appear to down-regulate the β-adrenoceptor system while, simultaneously, increasing melatonin output. Atypical antidepressants and those that selectively inhibit serotonin reuptake appear to be without these effects when administered repeatedly. The pineal gland of normal rats may therefore not represent a suitable model for evaluating the biochemical effects of chronic antidepressant treatment. In an attempt to investigatc pineal gland function in rats with "model depression" , antidepressants were administered to chronically reserpinized rats. Treatment with reserpine produced an increase in the density of pineal β-adrenoceptors. In addition, pineal cyclic AMP accumulation and N-acetyltransferase activity were increased in reserpinized rats following exogenous catecholamine stimulation. Reserpine, by depleting intraneuronal catecholamine stores, prevented the nocturnal induction of N-acetyltransferase activity and reduced the synthesis of melatonin in pineal gland cultures. A variety of antidepressants, irrespective of their acute pharmacological actions, reversed these effects when administered chronically to resepinized rats. Acute antidepressant administration was not associated with a reversal of the reserpine-induced effects. These findings provide additional evidence against the hypothesis that antidepressant drugs act by reducing noradrenergic neurotransmission and casts doubt on the importance of β-adrenoceptor down-regulation in the mechanism of antidepressant action. The possibility that the pineal gland of the reserpinized rat may represent an alternative model for evaluating antidepressant therapies is discussed.
- Full Text:
- Date Issued: 1992
- Authors: Banoo, Shabir
- Date: 1992
- Subjects: Antidepressants -- Research , Pineal gland -- Research
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:3744 , http://hdl.handle.net/10962/d1003222 , Antidepressants -- Research , Pineal gland -- Research
- Description: The rat pineal gland provides a convenient model for investigating nor adrenergic receptor neurotransmission and the effects of various drugs on these processes in health and disease. The effect of a variety of antidepressant drugs on rat pineal gland function following acute and chronic administration is described. Antidepressants from several different classes increase melatonin synthesis in rat pineal gland cultures when administered acutely. This effect appears to be mediated by noradrenaline acting on postsynaptic β-adrenoceptors. Activation of these receptors, in turn, activates the enzyme serotonin N-acetyltransferase via a cyclic adenosine monophosphate (cAMP) second messenger system. Serotonin N-acetyltransferase catalyses the rate-limiting conversion of serotonin to melatonin. Blockade of postsynaptic β-adrenoceptors prevents the antidepressant-induced increase in melatonin synthesis. The possibility that atypical antidepressants as well as those that selectively inhibit serotonin reuptake may increase melatonin synthesis via a β-adrenoceptor mechanism is discussed. In contrast, however, antidepressants from different classes have variable effects on rat pineal gland function when administered repeatedly. Chronic treatment with antidepressants that selectively inhibit noradrenaline reuptake appear to down-regulate the β-adrenoceptor system while, simultaneously, increasing melatonin output. Atypical antidepressants and those that selectively inhibit serotonin reuptake appear to be without these effects when administered repeatedly. The pineal gland of normal rats may therefore not represent a suitable model for evaluating the biochemical effects of chronic antidepressant treatment. In an attempt to investigatc pineal gland function in rats with "model depression" , antidepressants were administered to chronically reserpinized rats. Treatment with reserpine produced an increase in the density of pineal β-adrenoceptors. In addition, pineal cyclic AMP accumulation and N-acetyltransferase activity were increased in reserpinized rats following exogenous catecholamine stimulation. Reserpine, by depleting intraneuronal catecholamine stores, prevented the nocturnal induction of N-acetyltransferase activity and reduced the synthesis of melatonin in pineal gland cultures. A variety of antidepressants, irrespective of their acute pharmacological actions, reversed these effects when administered chronically to resepinized rats. Acute antidepressant administration was not associated with a reversal of the reserpine-induced effects. These findings provide additional evidence against the hypothesis that antidepressant drugs act by reducing noradrenergic neurotransmission and casts doubt on the importance of β-adrenoceptor down-regulation in the mechanism of antidepressant action. The possibility that the pineal gland of the reserpinized rat may represent an alternative model for evaluating antidepressant therapies is discussed.
- Full Text:
- Date Issued: 1992
Ngalanga 1st movement
- Venancio Mbande and his Timbila players, Tracey, Andrew T N
- Authors: Venancio Mbande and his Timbila players , Tracey, Andrew T N
- Date: 1992
- Subjects: Chopi (African people) -- Music , Folk music -- South Africa , Xylophone (Musical instrument) , Drum (Musical instruments) , Sub-Saharan African music , Africa South Africa Wildebeesfontein f-za
- Language: Chopi
- Type: sound recordings , field recordings , sound recording-musical
- Identifier: http://hdl.handle.net/10962/98867 , vital:31635 , International Library of African Music, Rhodes University, Grahamstown, South Africa , ATC076a-01
- Description: Traditional Ngalanga dance song for young people with 3 Timbila xylophone and 3 drums accompaniment
- Full Text: false
- Date Issued: 1992
- Authors: Venancio Mbande and his Timbila players , Tracey, Andrew T N
- Date: 1992
- Subjects: Chopi (African people) -- Music , Folk music -- South Africa , Xylophone (Musical instrument) , Drum (Musical instruments) , Sub-Saharan African music , Africa South Africa Wildebeesfontein f-za
- Language: Chopi
- Type: sound recordings , field recordings , sound recording-musical
- Identifier: http://hdl.handle.net/10962/98867 , vital:31635 , International Library of African Music, Rhodes University, Grahamstown, South Africa , ATC076a-01
- Description: Traditional Ngalanga dance song for young people with 3 Timbila xylophone and 3 drums accompaniment
- Full Text: false
- Date Issued: 1992
Ngalanga 2nd movements
- Venancio Mbande and his Timbila players, Tracey, Andrew T N
- Authors: Venancio Mbande and his Timbila players , Tracey, Andrew T N
- Date: 1992
- Subjects: Chopi (African people) -- Music , Folk music -- South Africa , Xylophone (Musical instrument) , Drum (Musical instruments) , Sub-Saharan African music , Africa South Africa Wildebeesfontein f-za
- Language: Chopi
- Type: sound recordings , field recordings , sound recording-musical
- Identifier: http://hdl.handle.net/10962/98872 , vital:31636 , International Library of African Music, Rhodes University, Grahamstown, South Africa , ATC076a-02
- Description: Traditional Ngalanga dance song for young people with 3 Timbila xylophone and 3 drums accompaniment
- Full Text: false
- Date Issued: 1992
- Authors: Venancio Mbande and his Timbila players , Tracey, Andrew T N
- Date: 1992
- Subjects: Chopi (African people) -- Music , Folk music -- South Africa , Xylophone (Musical instrument) , Drum (Musical instruments) , Sub-Saharan African music , Africa South Africa Wildebeesfontein f-za
- Language: Chopi
- Type: sound recordings , field recordings , sound recording-musical
- Identifier: http://hdl.handle.net/10962/98872 , vital:31636 , International Library of African Music, Rhodes University, Grahamstown, South Africa , ATC076a-02
- Description: Traditional Ngalanga dance song for young people with 3 Timbila xylophone and 3 drums accompaniment
- Full Text: false
- Date Issued: 1992
Ngalanga 3rd movement
- Venancio Mbande and his Timbila players, Tracey, Andrew T N
- Authors: Venancio Mbande and his Timbila players , Tracey, Andrew T N
- Date: 1992
- Subjects: Chopi (African people) -- Music , Folk music -- South Africa , Xylophone (Musical instrument) , Drum (Musical instruments) , Sub-Saharan African music , Africa South Africa Wildebeesfontein f-za
- Language: Chopi
- Type: sound recordings , field recordings , sound recording-musical
- Identifier: http://hdl.handle.net/10962/98877 , vital:31637 , International Library of African Music, Rhodes University, Grahamstown, South Africa , ATC076a-03
- Description: Traditional Ngalanga dance song for young people with 3 Timbila xylophone and 3 drums accompaniment
- Full Text: false
- Date Issued: 1992
- Authors: Venancio Mbande and his Timbila players , Tracey, Andrew T N
- Date: 1992
- Subjects: Chopi (African people) -- Music , Folk music -- South Africa , Xylophone (Musical instrument) , Drum (Musical instruments) , Sub-Saharan African music , Africa South Africa Wildebeesfontein f-za
- Language: Chopi
- Type: sound recordings , field recordings , sound recording-musical
- Identifier: http://hdl.handle.net/10962/98877 , vital:31637 , International Library of African Music, Rhodes University, Grahamstown, South Africa , ATC076a-03
- Description: Traditional Ngalanga dance song for young people with 3 Timbila xylophone and 3 drums accompaniment
- Full Text: false
- Date Issued: 1992
Ngalanga 4th movement
- Venancio Mbande and his Timbila players, Tracey, Andrew T N
- Authors: Venancio Mbande and his Timbila players , Tracey, Andrew T N
- Date: 1992
- Subjects: Chopi (African people) -- Music , Folk music -- South Africa , Xylophone (Musical instrument) , Drum (Musical instruments) , Sub-Saharan African music , Africa South Africa Wildebeesfontein f-za
- Language: Chopi
- Type: sound recordings , field recordings , sound recording-musical
- Identifier: http://hdl.handle.net/10962/98884 , vital:31638 , International Library of African Music, Rhodes University, Grahamstown, South Africa , ATC076a-04
- Description: Traditional Ngalanga dance song for young people with 3 Timbila xylophone and 3 drums accompaniment
- Full Text: false
- Date Issued: 1992
- Authors: Venancio Mbande and his Timbila players , Tracey, Andrew T N
- Date: 1992
- Subjects: Chopi (African people) -- Music , Folk music -- South Africa , Xylophone (Musical instrument) , Drum (Musical instruments) , Sub-Saharan African music , Africa South Africa Wildebeesfontein f-za
- Language: Chopi
- Type: sound recordings , field recordings , sound recording-musical
- Identifier: http://hdl.handle.net/10962/98884 , vital:31638 , International Library of African Music, Rhodes University, Grahamstown, South Africa , ATC076a-04
- Description: Traditional Ngalanga dance song for young people with 3 Timbila xylophone and 3 drums accompaniment
- Full Text: false
- Date Issued: 1992
Ngalanga 5th movement
- Venancio Mbande and his Timbila players, Tracey, Andrew T N
- Authors: Venancio Mbande and his Timbila players , Tracey, Andrew T N
- Date: 1992
- Subjects: Chopi (African people) -- Music , Folk music -- South Africa , Xylophone (Musical instrument) , Drum (Musical instruments) , Sub-Saharan African music , Africa South Africa Wildebeesfontein f-za
- Language: Chopi
- Type: sound recordings , field recordings , sound recording-musical
- Identifier: http://hdl.handle.net/10962/98903 , vital:31641 , International Library of African Music, Rhodes University, Grahamstown, South Africa , ATC076a-05
- Description: Traditional Ngalanga dance song for young people with 3 Timbila xylophone and 3 drums accompaniment
- Full Text: false
- Date Issued: 1992
- Authors: Venancio Mbande and his Timbila players , Tracey, Andrew T N
- Date: 1992
- Subjects: Chopi (African people) -- Music , Folk music -- South Africa , Xylophone (Musical instrument) , Drum (Musical instruments) , Sub-Saharan African music , Africa South Africa Wildebeesfontein f-za
- Language: Chopi
- Type: sound recordings , field recordings , sound recording-musical
- Identifier: http://hdl.handle.net/10962/98903 , vital:31641 , International Library of African Music, Rhodes University, Grahamstown, South Africa , ATC076a-05
- Description: Traditional Ngalanga dance song for young people with 3 Timbila xylophone and 3 drums accompaniment
- Full Text: false
- Date Issued: 1992
Nickel sulphide mineralization associated with Archean komatiites
- Authors: Lane, Monica Leonie
- Date: 1992
- Subjects: Nickel sulfide , Geology, Stratigraphic -- Archaean
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4982 , http://hdl.handle.net/10962/d1005594 , Nickel sulfide , Geology, Stratigraphic -- Archaean
- Description: The distribution of Archean Nickel sulphide deposits reflects tectonic controls operating during the evolution of the granitoid greenstone terrains. Important deposits of komatiitic-affinity are concentrated within, and adjacent to, younger (∼2.7 Ga), rift-related greenstone belts (e.g. Canada, Western Australia and Zimababwe). Two important classes of Archean Nickel sulphide deposits exist, formerly known as "Dunitic" and "Peridotitic", these are now referred to as Group I and Group II deposits, based on their characteristic structure and composition. Mineralization varies from massive and matrix to disseminated, and is nearly always concentrated at the base of the host unit. Primary ores have a relatively simple mineralogy, dominated by pyrrhotite-pentlandite-pyrite, and to a lesser degree millerite. Metamorphic grades tend to range from prehnite-pumpellyite facies through to lower and upper amphibolite facies. Genesis of Group I and II deposits is explained by the eruption of komatiites into rift-phase greenstone belts, as channelized flows, which assimilated variable amounts of footwall rocks during emplacement. Sulphide saturation was dependent on the mode of emplacement and, the amount of sulphidic sediments that became assimilated prior to crystallization. This possibly accounts for variations in ore tenor. The Six Mile Deposit (SMD) in Western Australia, is an adcumulate body of the Group IIB-type, exhibiting disseminated mineralization. The ore has been "upgraded" due to hydration and serpentinization. A profound weathering sequence exists, which was subsequently utilized during initial exploration. Exploration techniques has been focused on Western Australia, as it is here that the most innovative ideas have emerged.
- Full Text:
- Date Issued: 1992
- Authors: Lane, Monica Leonie
- Date: 1992
- Subjects: Nickel sulfide , Geology, Stratigraphic -- Archaean
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4982 , http://hdl.handle.net/10962/d1005594 , Nickel sulfide , Geology, Stratigraphic -- Archaean
- Description: The distribution of Archean Nickel sulphide deposits reflects tectonic controls operating during the evolution of the granitoid greenstone terrains. Important deposits of komatiitic-affinity are concentrated within, and adjacent to, younger (∼2.7 Ga), rift-related greenstone belts (e.g. Canada, Western Australia and Zimababwe). Two important classes of Archean Nickel sulphide deposits exist, formerly known as "Dunitic" and "Peridotitic", these are now referred to as Group I and Group II deposits, based on their characteristic structure and composition. Mineralization varies from massive and matrix to disseminated, and is nearly always concentrated at the base of the host unit. Primary ores have a relatively simple mineralogy, dominated by pyrrhotite-pentlandite-pyrite, and to a lesser degree millerite. Metamorphic grades tend to range from prehnite-pumpellyite facies through to lower and upper amphibolite facies. Genesis of Group I and II deposits is explained by the eruption of komatiites into rift-phase greenstone belts, as channelized flows, which assimilated variable amounts of footwall rocks during emplacement. Sulphide saturation was dependent on the mode of emplacement and, the amount of sulphidic sediments that became assimilated prior to crystallization. This possibly accounts for variations in ore tenor. The Six Mile Deposit (SMD) in Western Australia, is an adcumulate body of the Group IIB-type, exhibiting disseminated mineralization. The ore has been "upgraded" due to hydration and serpentinization. A profound weathering sequence exists, which was subsequently utilized during initial exploration. Exploration techniques has been focused on Western Australia, as it is here that the most innovative ideas have emerged.
- Full Text:
- Date Issued: 1992